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Nicotine (neuromuscular) antagonist. Skeletal muscle relaxant.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 732.68. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.36 mL||6.82 mL||13.65 mL|
|5 mM||0.27 mL||1.36 mL||2.73 mL|
|10 mM||0.14 mL||0.68 mL||1.36 mL|
|50 mM||0.03 mL||0.14 mL||0.27 mL|
References are publications that support the biological activity of the product.
Fryer and Maclagan (1987) Pancuronium and gallamine are antagonists for pre- and post-junctional muscarinic receptors in the guinea-pig lung. Naunyn Schmiedebergs Arch.Pharmacol. 335 367 PMID: 3600815
Lowenick et al (2001) Open channel and competitive block of nicotinic receptors by pancur. and atrac. Eur.J.Pharmacol. 413 31 PMID: 11173060
Maestrone et al (1994) Extracellular pancur. affects sodium current in chick embryo sensory neurones. Br.J.Pharmacol. 111 283 PMID: 8012707
Merck Index 12 7139
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Keywords: Pancuronium dibromide, Pancuronium dibromide supplier, Nicotinic, neuromuscular, antagonists, Acetylcholine, Receptors, Non-Selective, nAChR, skeletal, muscle, relaxant, (Non-selective), 0693, Tocris Bioscience
2 Citations for Pancuronium dibromide
Citations are publications that use Tocris products. Selected citations for Pancuronium dibromide include:
Candelier et al (2015) A microfluidic device to study neuronal and motor responses to acute chemical stimuli in zebrafish. Invest Ophthalmol Vis Sci 5 12196 PMID: 26194888
Dunfield and Haas (2009) Metaplasticity governs natural experience-driven plasticity of nascent embryonic brain circuits. Neuron 64 240 PMID: 19874791
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Literature in this Area
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.