Pancuronium dibromide

Pricing Availability Delivery Time Qty
Cat.No. 0693 - Pancuronium dibromide | C35H60Br2N2O4 | CAS No. 15500-66-0
Description: Nicotinic (neuromuscular) antagonist
Chemical Name: 1,1'-(3α,17β-Dihydroxy-2β,5α-androstan-2β,16β-ylene) bis[1-methylpiperidinium] diacetate dibromide
Purity: ≥99%
Datasheet
Citations (1)
Literature

Biological Activity

Nicotine (neuromuscular) antagonist. Skeletal muscle relaxant.

Technical Data

M. Wt 732.68
Formula C35H60Br2N2O4
Storage Desiccate at RT
Purity ≥99%
CAS Number 15500-66-0
PubChem ID 23581810
InChI Key NPIJXCQZLFKBMV-TZJMVAHLSA-L
Smiles [H][C@]34C2([H])CC[C@@]1([H])C[C@H](OC(C)=O)C([N+]6(C)CCCCC6)CC(C)1[C@]([H])2CCC(C)3C(OC(C)=O)C([N+]5(C)CCCCC5)C4.[Br-].[Br-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 14.65 20
ethanol 73.27 100
water 73.27 100

Preparing Stock Solutions

The following data is based on the product molecular weight 732.68. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.36 mL 6.82 mL 13.65 mL
5 mM 0.27 mL 1.36 mL 2.73 mL
10 mM 0.14 mL 0.68 mL 1.36 mL
50 mM 0.03 mL 0.14 mL 0.27 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Fryer and Maclagan (1987) Pancuronium and gallamine are antagonists for pre- and post-junctional muscarinic receptors in the guinea-pig lung. Naunyn Schmiedebergs Arch.Pharmacol. 335 367 PMID: 3600815

Lowenick et al (2001) Open channel and competitive block of nicotinic receptors by pancuronium and atracurium. Eur.J.Pharmacol. 413 31 PMID: 11173060

Maestrone et al (1994) Extracellular pancuronium affects sodium current in chick embryo sensory neurones. Br.J.Pharmacol. 111 283 PMID: 8012707

Merck Index 12 7139 PMID:


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Keywords: Pancuronium dibromide, supplier, Nicotinic, neuromuscular, antagonists, Acetylcholine, Receptors, Non-Selective, nAChR, skeletal, muscle, relaxant, Nicotinic, Receptors, (Non-selective), Nicotinic, Receptors, (Non-selective), Tocris Bioscience

1 Citation for Pancuronium dibromide

Citations are publications that use Tocris products. Selected citations for Pancuronium dibromide include:

Candelier et al (2015) A microfluidic device to study neuronal and motor responses to acute chemical stimuli in zebrafish. Invest Ophthalmol Vis Sci 5 12196 PMID: 26194888


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