Pancuronium dibromide

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Cat.No. 0693 - Pancuronium dibromide | C35H60Br2N2O4 | CAS No. 15500-66-0
Description: Neuromusclar nAChR antagonist
Chemical Name: 1,1'-(3α,17β-Dihydroxy-2β,5α-androstan-2β,16β-ylene) bis[1-methylpiperidinium] diacetate dibromide
Purity: ≥99%
Citations (2)
Literature (3)

Biological Activity

Nicotine (neuromuscular) antagonist. Skeletal muscle relaxant.

Technical Data

M. Wt 732.68
Formula C35H60Br2N2O4
Storage Desiccate at RT
Purity ≥99%
CAS Number 15500-66-0
PubChem ID 23581810
Smiles [H][C@]34C2([H])CC[C@@]1([H])C[C@H](OC(C)=O)C([N+]6(C)CCCCC6)CC(C)1[C@]([H])2CCC(C)3C(OC(C)=O)C([N+]5(C)CCCCC5)C4.[Br-].[Br-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 73.27 100

Preparing Stock Solutions

The following data is based on the product molecular weight 732.68. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

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Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.36 mL 6.82 mL 13.65 mL
5 mM 0.27 mL 1.36 mL 2.73 mL
10 mM 0.14 mL 0.68 mL 1.36 mL
50 mM 0.03 mL 0.14 mL 0.27 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Fryer and Maclagan (1987) Pancuronium and gallamine are antagonists for pre- and post-junctional muscarinic receptors in the guinea-pig lung. Naunyn Schmiedebergs Arch.Pharmacol. 335 367 PMID: 3600815

Lowenick et al (2001) Open channel and competitive block of nicotinic receptors by pancur. and atrac. Eur.J.Pharmacol. 413 31 PMID: 11173060

Maestrone et al (1994) Extracellular pancur. affects sodium current in chick embryo sensory neurones. Br.J.Pharmacol. 111 283 PMID: 8012707

Merck Index 12 7139

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Keywords: Pancuronium dibromide, Pancuronium dibromide supplier, Nicotinic, neuromuscular, antagonists, Acetylcholine, Receptors, Non-Selective, nAChR, skeletal, muscle, relaxant, (Non-selective), 0693, Tocris Bioscience

2 Citations for Pancuronium dibromide

Citations are publications that use Tocris products. Selected citations for Pancuronium dibromide include:

Candelier et al (2015) A microfluidic device to study neuronal and motor responses to acute chemical stimuli in zebrafish. Invest Ophthalmol Vis Sci 5 12196 PMID: 26194888

Dunfield and Haas (2009) Metaplasticity governs natural experience-driven plasticity of nascent embryonic brain circuits. Neuron 64 240 PMID: 19874791

Do you know of a great paper that uses Pancuronium dibromide from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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