You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Palonosetron hydrochloride New
Highly potent and high affinity 5-HT3 antagonist (IC50 = 0.24 nM for 5-HT3A; pKi = 10.4). Displays a slow dissociation rate. Inhibits 5-HT-induced enhancement of cellular response to substance P (Cat. No. 1156) in vitro. Inhibits cisplatin (Cat. No. 2251)-induced enhancement of substance P response in vivo.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 332.87. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3 mL||15.02 mL||30.04 mL|
|5 mM||0.6 mL||3 mL||6.01 mL|
|10 mM||0.3 mL||1.5 mL||3 mL|
|50 mM||0.06 mL||0.3 mL||0.6 mL|
References are publications that support the biological activity of the product.
Wong et al (1995) The interaction of RS 25259-197, a potent and selective antagonist, with 5-HT3 receptors, in vitro. Br.J.Pharmacol. 114 851 PMID: 7773546
Rojas et al (2010) The antiemetic 5-HT3 receptor antagonist Palonosetron inhibits substance P-mediated responses in vitro and in vivo. J.Pharmacol.Exp.Ther. 335 362 PMID: 20724484
Lummis & Thompson (2013) Agonists and antagonists induce different palonosetron dissociation rates in 5-HT3A and 5-HT3AB receptors. Neuropharmacology. 73 241 PMID: 23747573
Del Cadia et al (2013) Exploring a potential palonosetron allosteric binding site in the 5-HT(3) receptor. Bioorg.Med.Chem. 21 7523 PMID: 24128813
If you know of a relevant reference for Palonosetron hydrochloride, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Palonosetron hydrochloride, Palonosetron hydrochloride supplier, serotonin, 5-HT3, receptor, antagonist, antagonism, highly, potent, high, potency, affinity, antiemtic, chemotherapy, induced, vomiting, nausea, Receptors, 7038, Tocris Bioscience
Citations for Palonosetron hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for Palonosetron hydrochloride. Do you know of a great paper that uses Palonosetron hydrochloride from Tocris? Please let us know.
Reviews for Palonosetron hydrochloride
There are currently no reviews for this product. Be the first to review Palonosetron hydrochloride and earn rewards!
Have you used Palonosetron hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.