PAF (C16)

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Description: Endogenous platelet-activating factor (PAF)
Alternative Names: Platelet-activating factor
Chemical Name: (7R)-7-(Acetyloxy)-4-hydroxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphapentacosan-1-aminium-4-oxide
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Biological Activity for PAF (C16)

PAF (C16) is an endogenous platelet-activating factor (PAF) and ligand for PAF receptors. Produced by inflammatory cells and a potent chemoattractant for polymorphonuclear neutrophils. Induces increased vascular permeability.

Technical Data for PAF (C16)

M. Wt 523.68
Formula C26H54NO7P
Storage Store at -20°C
CAS Number 74389-68-7
PubChem ID 108156

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PAF (C16)

Solvent Max Conc. mg/mL Max Conc. mM
water 52.37 100

Preparing Stock Solutions for PAF (C16)

The following data is based on the product molecular weight 523.68. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.91 mL 9.55 mL 19.1 mL
5 mM 0.38 mL 1.91 mL 3.82 mL
10 mM 0.19 mL 0.95 mL 1.91 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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Product Datasheets for PAF (C16)

Certificate of Analysis / Product Datasheet
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References for PAF (C16)

References are publications that support the biological activity of the product.

Oda et al (1985) Molecular species of platelet-activating factor generated by human neutrophils challenged with ionophore A23187. J.Immunol. 134 1090 PMID: 3917470

Archer et al (1988) Actions of platelet activating factor (PAF) homologues and their combinations on neutrophil chemokinesis and cutaneous inflammatory responses in man. J.Invest.Dermatol. 91 82 PMID: 3385217

Handa et al (1991) Vasorelaxant effect of C16-PAF and C18-PAF on renal blood flow and systemic blood pressure in the anesthetized rat. Life Sci. 49 747 PMID: 1875784

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Keywords: PAF (C16), PAF (C16) supplier, Endogenous, platelet-activating, factor, PAF, Receptors, Platelet-activating, Factor, (PAF), 2940, Tocris Bioscience

Citations for PAF (C16)

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Reviews for PAF (C16)

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Platelet activating factor (PAF).
By Anonymous on 05/02/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: microglia

Platelet activating factor (PAF) at 100nM induced a biphasic calcium response in microglia culture. Initial release from internal source and subsequent a sustained influx.