PAF (C16)

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Cat.No. 2940 - PAF (C16) | C26H54NO7P | CAS No. 74389-68-7
Description: Endogenous platelet-activating factor (PAF)
Alternative Names: Platelet-activating factor
Chemical Name: (7R)-7-(Acetyloxy)-4-hydroxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphapentacosan-1-aminium-4-oxide
Datasheet
Citations
Reviews (1)
Literature

Biological Activity

Endogenous platelet-activating factor (PAF) and ligand for PAF receptors. Produced by inflammatory cells and a potent chemoattractant for polymorphonuclear neutrophils. Induces increased vascular permeability.

Technical Data

M. Wt 523.68
Formula C26H54NO7P
Storage Desiccate at -20°C
CAS Number 74389-68-7
PubChem ID 108156
InChI Key HVAUUPRFYPCOCA-AREMUKBSSA-N
Smiles CC(O[C@@H](COP(OCC[N+](C)(C)C)([O-])=O)COCCCCCCCCCCCCCCCC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 52.37 100
ethanol 52.37 100

Preparing Stock Solutions

The following data is based on the product molecular weight 523.68. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.91 mL 9.55 mL 19.1 mL
5 mM 0.38 mL 1.91 mL 3.82 mL
10 mM 0.19 mL 0.95 mL 1.91 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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Product Datasheets

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Safety Datasheet

References

References are publications that support the biological activity of the product.

Oda et al (1985) Molecular species of platelet-activating factor generated by human neutrophils challenged with ionophore A23187. J.Immunol. 134 1090 PMID: 3917470

Archer et al (1988) Actions of platelet activating factor (PAF) homologues and their combinations on neutrophil chemokinesis and cutaneous inflammatory responses in man. J.Invest.Dermatol. 91 82 PMID: 3385217

Handa et al (1991) Vasorelaxant effect of C16-PAF and C18-PAF on renal blood flow and systemic blood pressure in the anesthetized rat. Life Sci. 49 747 PMID: 1875784


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Keywords: PAF (C16), PAF (C16) supplier, Endogenous, platelet-activating, factor, PAF, Receptors, Platelet-activating, Factor, (PAF), 2940, Tocris Bioscience

Citations for PAF (C16)

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Platelet activating factor (PAF)
By Anonymous on 05/02/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: microglia

Platelet activating factor (PAF) at 100nM induced a biphasic calcium response in microglia culture. Initial release from internal source and subsequent a sustained influx.


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