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Description: Irreversible protein disulfide isomerase (PDI) inhibitor
Chemical Name: N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycylglycine ethyl ester
Purity: ≥99% (HPLC)
Literature (1)

Biological Activity for PACMA 31

PACMA 31 is an irreversible protein disulfide isomerase (PDI) inhibitor; inhibits growth of ovarian cancer cells. Suppresses tumor growth in a mouse xenograph model of human ovarian cancer.

Compound Libraries for PACMA 31

PACMA 31 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PACMA 31

M. Wt 430.47
Formula C21H22N2O6S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 1401089-31-3
PubChem ID 66555902
Smiles O=C(C#C)N(C(C2=CC=CS2)C(NCC(OCC)=O)=O)C1=CC=C(OC)C=C1OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PACMA 31

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 43.05 100

Preparing Stock Solutions for PACMA 31

The following data is based on the product molecular weight 430.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.32 mL 11.62 mL 23.23 mL
5 mM 0.46 mL 2.32 mL 4.65 mL
10 mM 0.23 mL 1.16 mL 2.32 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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References for PACMA 31

References are publications that support the biological activity of the product.

Ge et al (2013) Small molecule probe suitable for in situ profiling and inhibition of protein disulfide isomerase. ACS.Chem.Biol. 8 2577 PMID: 24070012

Xu et al (2012) Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment. Proc.Natl.Acad.Sci.U.S.A. 109 16348 PMID: 22988091

If you know of a relevant reference for PACMA 31, please let us know.

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Citations for PACMA 31

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Literature in this Area

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