Protein Disulfide Isomerase

Protein Disulfide Isomerase (PDI, EC 5.3.4.1) is a multifunctional redox protein which acts as a regulator of disulfide bond formation and rearrangement (isomerization). In doing so it functions as both an enzyme and as a molecular chaperone.

Products
Background
Literature
Gene Data

Inhibitors

Cat. No. Product Name / Activity
6063 CCF 642
Protein disulfide isomerase (PDI) inhibitor
5606 LOC14
High affinity protein disulfide isomerase (PDI) modulator
5127 P1
Protein disulfide isomerase (PDI) inhibitor
5116 PACMA 31
Irreversible protein disulfide isomerase (PDI) inhibitor

Related Targets

    Protein Disulfide Isomerase (PDI, EC 5.4.3.1) is a multifunctional redox protein which acts as a regulator of disulfide bond formation and rearrangement (isomerization). In doing so it functions as both an enzyme and as a molecular chaperone.

    PDI, the first catalyst of protein folding to be characterized, is a member of the PDI family of proteins which are mainly localized to the endoplasmic reticulum (ER), are upregulated in response to ER stress and have an important role in protein homeostasis.

    This soluble 55 kDa protein consists of four thioredoxin-like domains arranged in a U-shape conformation with a C-terminal tail. Cysteine residues of a -CGHC- motif within the active sites of PDI react with thiol (R-SH) groups of substrate proteins to form disulfide bonds in a thiol-disulfide interchange.

    Alterations in cellular levels of PDI are associated with a range of diseases, for example, PDI upregulation has been shown to promote cancer cell survival in some types of breast cancer and thrombosis formation in cardiovascular disease. It may also have a protective effect in neurodegenerative disorders where it has been suggested to be a defence mechanism against protein aggregation.

    External sources of pharmacological information for Protein Disulfide Isomerase :

      Literature for Protein Disulfide Isomerase

      Tocris offers the following scientific literature for Protein Disulfide Isomerase to showcase our products. We invite you to request* or download your copy today!

      *Please note that Tocris will only send literature to established scientific business / institute addresses.


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      Protein Disulfide Isomerase Gene Data

      Gene Species Gene Symbol Gene Accession No. Protein Accession No.
      Protein Disulfide Isomerase
      P4HB Human P4HB NM_000918 P07237
      Mouse P4hb NM_011032 P09103
      Rat P4hb NM_012998 P04785
      PDIA2 Human PDIA2 NM_006849 Q13087
      Mouse Pdia2 NM_001081070 D3Z6P0
      Rat Pdia2 NM_001105775 NP_001099245
      PDIA3 Human PDIA3 NM_005313 P30101
      Mouse Pdia3 NM_007952 P27773
      Rat Pdia3 NM_017319 P11598
      PDIA4 Human PDIA4 NM_004911 P13667
      Mouse Pdia4 NM_009787 P08003
      Rat Pdia4 NM_053849 P38659
      PDIA5 Human PDIA5 NM_006810 Q14554
      Mouse Pdia5 NM_028295 Q921X9
      Rat Pdia5 NM_001014125 Q5I0H9
      PDIA6 Human PDIA6 NM_005742 Q15084
      Mouse Pdia6 NM_027959 Q922R8
      Rat Pdia6 NM_001004442 Q63081
      PDILT Human PDILT NM_174924 Q8N807
      Mouse Pdilt NM_027943 Q9DAN1
      Rat Pdilt NM_001013902 Q5XI02
      ERP27 Human ERP27 NM_152321 Q96DN0
      Mouse Erp27 NM_026983 Q9D8U3
      Rat Erp27 NM_001106625 NP_001100095
      ERP29 Human ERP29 NM_001034025 P30040
      Mouse Erp29 NM_026129 P57759
      Rat Erp29 NM_053961 P52555
      ERP44 Human ERP44 XM_088476 Q9BS26
      Mouse Erp44 NM_029572 Q9D1Q6
      Rat Erp44 NM_001008317 NP_001008318
      TMX1 Human TMX1 NM_030755 Q9H3N1
      Mouse Tmx1 NM_028339 Q8VBT0
      Rat Tmx1 NM_001024800 NP_001019971
      TMX2 Human TMX2 NM_015959 Q9Y320
      Mouse Tmx2 NM_025868 Q9D710
      Rat Tmx2 NM_001007643 Q5XIK2
      TMX3 Human TMX3 NM_019022 Q96JJ7
      Mouse Tmx3 NM_198295 Q8BXZ1
      Rat Tmx3 XM_001063895 XP_001063895
      TMX4 Human TMX4 NM_021156 Q9H1E5
      Mouse Tmx4 NM_029148 Q8C0L0
      Rat Tmx4 NM_001100529 NP_001093999
      TXNDC5 Human TXNDC5 NM_030810 Q8NBS9
      Mouse Txndc5 NM_145367 Q91W90
      Rat Txndc5 NM_001271330 NP_001258259
      TXNDC12 Human TXNDC12 NM_015913 O95881
      Mouse Txndc12 NM_025334 Q9CQU0
      Rat Txndc12 NM_001100840 Q498E0
      AGR2 Human AGR2 NM_006408 O95994
      Mouse Agr2 NM_011783 O88312
      Rat Agr2 NM_001106725 NP_001100195
      AGR3 Human AGR3 NM_176813 Q8TD06
      Mouse Agr3 NM_207531 Q8R3W7
      Rat Agr3 NM_001106724 NP_001100194
      DNAJC10 Human DNAJC10 NM_018981 Q8IXB1
      Mouse Dnajc10 NM_024181 Q9DC23
      Rat Dnajc10 NM_001106486 Q498R3
      CASQ1 Human CASQ1 NM_001231 P31415
      Mouse Casq1 NM_009813 O09165
      Rat Casq1 NM_001159594 P19633
      CASQ2 Human CASQ2 NM_001232 O14958
      Mouse Casq2 NM_009814 O09161
      Rat Casq2 NM_017131 P51868