Protein Disulfide Isomerase

Protein Disulfide Isomerase (PDI, EC 5.3.4.1) is a multifunctional redox protein which acts as a regulator of disulfide bond formation and rearrangement (isomerization). In doing so it functions as both an enzyme and as a molecular chaperone.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
6063 CCF 642
Protein disulfide isomerase (PDI) inhibitor
5606 LOC14
High affinity protein disulfide isomerase (PDI) modulator
5127 P1
Protein disulfide isomerase (PDI) inhibitor
5116 PACMA 31
Irreversible protein disulfide isomerase (PDI) inhibitor

Related Targets

    Protein Disulfide Isomerase (PDI, EC 5.4.3.1) is a multifunctional redox protein which acts as a regulator of disulfide bond formation and rearrangement (isomerization). In doing so it functions as both an enzyme and as a molecular chaperone.

    PDI, the first catalyst of protein folding to be characterized, is a member of the PDI family of proteins which are mainly localized to the endoplasmic reticulum (ER), are upregulated in response to ER stress and have an important role in protein homeostasis.

    This soluble 55 kDa protein consists of four thioredoxin-like domains arranged in a U-shape conformation with a C-terminal tail. Cysteine residues of a -CGHC- motif within the active sites of PDI react with thiol (R-SH) groups of substrate proteins to form disulfide bonds in a thiol-disulfide interchange.

    Alterations in cellular levels of PDI are associated with a range of diseases, for example, PDI upregulation has been shown to promote cancer cell survival in some types of breast cancer and thrombosis formation in cardiovascular disease. It may also have a protective effect in neurodegenerative disorders where it has been suggested to be a defence mechanism against protein aggregation.

    Literature for Protein Disulfide Isomerase

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    Protein Disulfide Isomerase Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    Protein Disulfide Isomerase
    P4HB Human P4HB NM_000918 P07237
    Mouse P4hb NM_011032 P09103
    Rat P4hb NM_012998 P04785
    PDIA2 Human PDIA2 NM_006849 Q13087
    Mouse Pdia2 NM_001081070 D3Z6P0
    Rat Pdia2 NM_001105775 NP_001099245
    PDIA3 Human PDIA3 NM_005313 P30101
    Mouse Pdia3 NM_007952 P27773
    Rat Pdia3 NM_017319 P11598
    PDIA4 Human PDIA4 NM_004911 P13667
    Mouse Pdia4 NM_009787 P08003
    Rat Pdia4 NM_053849 P38659
    PDIA5 Human PDIA5 NM_006810 Q14554
    Mouse Pdia5 NM_028295 Q921X9
    Rat Pdia5 NM_001014125 Q5I0H9
    PDIA6 Human PDIA6 NM_005742 Q15084
    Mouse Pdia6 NM_027959 Q922R8
    Rat Pdia6 NM_001004442 Q63081
    PDILT Human PDILT NM_174924 Q8N807
    Mouse Pdilt NM_027943 Q9DAN1
    Rat Pdilt NM_001013902 Q5XI02
    ERP27 Human ERP27 NM_152321 Q96DN0
    Mouse Erp27 NM_026983 Q9D8U3
    Rat Erp27 NM_001106625 NP_001100095
    ERP29 Human ERP29 NM_001034025 P30040
    Mouse Erp29 NM_026129 P57759
    Rat Erp29 NM_053961 P52555
    ERP44 Human ERP44 XM_088476 Q9BS26
    Mouse Erp44 NM_029572 Q9D1Q6
    Rat Erp44 NM_001008317 NP_001008318
    TMX1 Human TMX1 NM_030755 Q9H3N1
    Mouse Tmx1 NM_028339 Q8VBT0
    Rat Tmx1 NM_001024800 NP_001019971
    TMX2 Human TMX2 NM_015959 Q9Y320
    Mouse Tmx2 NM_025868 Q9D710
    Rat Tmx2 NM_001007643 Q5XIK2
    TMX3 Human TMX3 NM_019022 Q96JJ7
    Mouse Tmx3 NM_198295 Q8BXZ1
    Rat Tmx3 XM_001063895 XP_001063895
    TMX4 Human TMX4 NM_021156 Q9H1E5
    Mouse Tmx4 NM_029148 Q8C0L0
    Rat Tmx4 NM_001100529 NP_001093999
    TXNDC5 Human TXNDC5 NM_030810 Q8NBS9
    Mouse Txndc5 NM_145367 Q91W90
    Rat Txndc5 NM_001271330 NP_001258259
    TXNDC12 Human TXNDC12 NM_015913 O95881
    Mouse Txndc12 NM_025334 Q9CQU0
    Rat Txndc12 NM_001100840 Q498E0
    AGR2 Human AGR2 NM_006408 O95994
    Mouse Agr2 NM_011783 O88312
    Rat Agr2 NM_001106725 NP_001100195
    AGR3 Human AGR3 NM_176813 Q8TD06
    Mouse Agr3 NM_207531 Q8R3W7
    Rat Agr3 NM_001106724 NP_001100194
    DNAJC10 Human DNAJC10 NM_018981 Q8IXB1
    Mouse Dnajc10 NM_024181 Q9DC23
    Rat Dnajc10 NM_001106486 Q498R3
    CASQ1 Human CASQ1 NM_001231 P31415
    Mouse Casq1 NM_009813 O09165
    Rat Casq1 NM_001159594 P19633
    CASQ2 Human CASQ2 NM_001232 O14958
    Mouse Casq2 NM_009814 O09161
    Rat Casq2 NM_017131 P51868