PA Nic

Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: Caged nicotine; photoactivated by one-photon and two-photon excitation
Chemical Name: (1S,2S)-1-((7-(Bis(carboxymethyl)amino)-2-oxo-2H-chromen-4-yl)methyl)-1-methyl-2-(pyridin-3-yl)pyrrolidin-1-ium ditrifluoroacetate
Purity: ≥98% (HPLC)

Biological Activity for PA Nic

PA Nic is a coumarin-caged nicotine. Releases nicotine when exposed to 390 ± 10 nm wavelength light (λmax = 404 nm). Suitable for two-photon uncaging at <900 nm (Maximum two-photon cross-section at 810 nm). Extinction coefficient (ε) 17,400 M-1cm-1. Evokes nicotinic currents in mouse brain slices under one and two-photon activation conditions.

Technical Data for PA Nic

M. Wt 679.52
Formula C24H26N3O6.C2F3O2.C2HF3O2
Storage Store at -20°C
Purity ≥98% (HPLC)
Smiles C[N@@+]1(CC2=CC(OC3=C2C=CC(N(CC(O)=O)CC(O)=O)=C3)=O)CCC[C@H]1C4=CC=CN=C4.OC(C(F)(F)F)=O.[O-]C(C(F)(F)F)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PA Nic

Solvent Max Conc. mg/mL Max Conc. mM
water 16.99 25
DMSO 16.99 25

Preparing Stock Solutions for PA Nic

The following data is based on the product molecular weight 679.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 5.89 mL 29.43 mL 58.87 mL
1.25 mM 1.18 mL 5.89 mL 11.77 mL
2.5 mM 0.59 mL 2.94 mL 5.89 mL
12.5 mM 0.12 mL 0.59 mL 1.18 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for PA Nic

References are publications that support the biological activity of the product.

Banala et al (2018) Photoactivatable drugs for nicotinic optopharmacology. Nat.Methods 15 347 PMID: 29578537

Yan et al (2018) Nicotinic cholinergic receptors in VTA glutamate neurons modulate excitatory transmission. Cell Rep. 23 2236 PMID: 29791835

Arvin et al (2019) Probing nicotinic acetylcholine receptor function in mouse brain slices via laser flash photolysis of photoactivatable nicotine. J.Vis.Exp. 143 e58873 PMID: 30735191

If you know of a relevant reference for PA Nic, please let us know.

Keywords: PA Nic, PA Nic supplier, PANic, caged, compounds, photoactivatable, nicotine, nicotinics, cholinergics, agonists, activators, nAChR, Nicotinic, Receptors, (Non-selective), Caged, Compounds, 6700, Tocris Bioscience

Citations for PA Nic

Citations are publications that use Tocris products.

Currently there are no citations for PA Nic. Do you know of a great paper that uses PA Nic from Tocris? Please let us know.

Reviews for PA Nic

There are currently no reviews for this product. Be the first to review PA Nic and earn rewards!

Have you used PA Nic?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review