PA Nic

Pricing Availability   Qty
Cat.No. 6700 - PA Nic | C24H26N3O6.C2F3O2.C2HF3O2
Description: Caged nicotine; photoactivated by one-photon and two-photon excitation
Chemical Name: (1S,2S)-1-((7-(Bis(carboxymethyl)amino)-2-oxo-2H-chromen-4-yl)methyl)-1-methyl-2-(pyridin-3-yl)pyrrolidin-1-ium ditrifluoroacetate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Coumarin-caged nicotine. Releases nicotine when exposed to 405 nm wavelength light (λmax = 404 nm). Suitable for two-photon uncaging at <900 nm (Maximum two-photon cross-section at 810 nm). Extinction coefficient (ε) 17,400 M-1cm-1, Evokes nicotinic currents in mouse brain slices under one and two-photon activation conditions.

Technical Data

M. Wt 679.52
Formula C24H26N3O6.C2F3O2.C2HF3O2
Storage Store at -20°C
Purity ≥98% (HPLC)
Smiles C[N@@+]1(CC2=CC(OC3=C2C=CC(N(CC(O)=O)CC(O)=O)=C3)=O)CCC[C@H]1C4=CC=CN=C4.OC(C(F)(F)F)=O.[O-]C(C(F)(F)F)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 16.99 25
DMSO 16.99 25

Preparing Stock Solutions

The following data is based on the product molecular weight 679.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 5.89 mL 29.43 mL 58.87 mL
1.25 mM 1.18 mL 5.89 mL 11.77 mL
2.5 mM 0.59 mL 2.94 mL 5.89 mL
12.5 mM 0.12 mL 0.59 mL 1.18 mL

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References

References are publications that support the biological activity of the product.

Banala et al (2018) Photoactivatable drugs for nicotinic optopharmacology. Nat.Methods 15 347 PMID: 29578537

Yan et al (2018) Nicotinic cholinergic receptors in VTA glutamate neurons modulate excitatory transmission. Cell Rep. 23 2236 PMID: 29791835

Arvin et al (2019) Probing nicotinic acetylcholine receptor function in mouse brain slices via laser flash photolysis of photoactivatable nicotine. J.Vis.Exp. 143 e58873


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Citations for PA Nic

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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