You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Coumarin-caged nicotine. Releases nicotine when exposed to 405 nm wavelength light (λmax = 404 nm). Suitable for two-photon uncaging at <900 nm (Maximum two-photon cross-section at 810 nm). Extinction coefficient (ε) 17,400 M-1cm-1, Evokes nicotinic currents in mouse brain slices under one and two-photon activation conditions.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 679.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.25 mM||5.89 mL||29.43 mL||58.87 mL|
|1.25 mM||1.18 mL||5.89 mL||11.77 mL|
|2.5 mM||0.59 mL||2.94 mL||5.89 mL|
|12.5 mM||0.12 mL||0.59 mL||1.18 mL|
References are publications that support the biological activity of the product.
Banala et al (2018) Photoactivatable drugs for nicotinic optopharmacology. Nat.Methods 15 347 PMID: 29578537
Yan et al (2018) Nicotinic cholinergic receptors in VTA glutamate neurons modulate excitatory transmission. Cell Rep. 23 2236 PMID: 29791835
Arvin et al (2019) Probing nicotinic acetylcholine receptor function in mouse brain slices via laser flash photolysis of photoactivatable nicotine. J.Vis.Exp. 143 e58873 PMID: 30735191
If you know of a relevant reference for PA Nic, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: PA Nic, PA Nic supplier, PANic, caged, compounds, photoactivatable, nicotine, nicotinics, cholinergics, agonists, activators, nAChR, Nicotinic, Receptors, (Non-selective), Other, Caged, Compounds, 6700, Tocris Bioscience
Citations for PA Nic
Citations are publications that use Tocris products.
Currently there are no citations for PA Nic. Do you know of a great paper that uses PA Nic from Tocris? Please let us know.
Reviews for PA Nic
There are currently no reviews for this product. Be the first to review PA Nic and earn rewards!
Have you used PA Nic?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.