P1075

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Cat.No. 1355 - P1075 | C12H17N5 | CAS No. 60559-98-0
Description: Potent Kir6 (KATP) channel opener
Chemical Name: N-cyano-N'-(1,1-dimethylpropyl)-N''-3-pyridylguanidine
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Potent Kir6 (KATP) channel opener (EC50 for relaxation of rat aorta = 7.5 nM). Binds to SUR2A and SUR2B with high affinity (Kd values are 17 and 3 nM respectively).

Technical Data

M. Wt 231.3
Formula C12H17N5
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 60559-98-0
PubChem ID 43345
InChI Key HKZNADVVGXKQDL-UHFFFAOYSA-N
Smiles CCC(C)(C)\N=C(/NC#N)NC1=CC=CN=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.13 100
ethanol 50

Preparing Stock Solutions

The following data is based on the product molecular weight 231.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.32 mL 21.62 mL 43.23 mL
5 mM 0.86 mL 4.32 mL 8.65 mL
10 mM 0.43 mL 2.16 mL 4.32 mL
50 mM 0.09 mL 0.43 mL 0.86 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Ashcroft and Gribble (2000) New windows on the mechanism of action of KATP channel openers. TiPS 21 439 PMID: 11121575

Buckner et al (2000) Pharmacological and molecular analysis of ATP-sensitive K+ channels in the pig and human detrusor. Eur.J.Pharmacol. 400 287 PMID: 10988346

Gross et al (1999) Stoichiometry of potassium channel opener action. Mol.Pharmacol. 56 1370 PMID: 10570067

Higdon et al (1997) Tissue and species variation in the vascular receptor binding of 3H-P1075, a potent KATP opener vasodilator. J.Pharmacol.Exp.Ther. 280 255 PMID: 8996204


If you know of a relevant reference for P1075, please let us know.

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Keywords: P1075, supplier, Potent, KATP, channel, openers, Potassium, KIR, Channels, Inward, Rectifier, K+, Kir6, Inward, rectifier, Potassium, Channels, Tocris Bioscience

1 Citation for P1075

Citations are publications that use Tocris products. Selected citations for P1075 include:

Baczkó et al (2005) Plasma membrane KATP channel-mediated cardioprotection involves posthypoxic reductions in calcium overload and contractile dysfunction: mechanistic insights into cardioplegia. FASEB J 19 980 PMID: 15774423


Do you know of a great paper that uses P1075 from Tocris? If so please let us know.

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Pathways for P1075

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