Potent Kir6 (KATP) channel opener (EC50 for relaxation of rat aorta = 7.5 nM). Binds to SUR2A and SUR2B with high affinity (Kd values are 17 and 3 nM respectively).
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 50 mM in ethanol and to 100 mM in DMSO|
References are publications that support the biological activity of the product.
Ashcroft and Gribble (2000) New windows on the mechanism of action of KATP channel openers. TiPS 21 439 PMID: 11121575
Buckner et al (2000) Pharmacological and molecular analysis of ATP-sensitive K+ channels in the pig and human detrusor. Eur.J.Pharmacol. 400 287 PMID: 10988346
Gross et al (1999) Stoichiometry of potassium channel opener action. Mol.Pharmacol. 56 1370 PMID: 10570067
Higdon et al (1997) Tissue and species variation in the vascular receptor binding of 3H-P1075, a potent KATP opener vasodilator. J.Pharmacol.Exp.Ther. 280 255 PMID: 8996204
If you know of a relevant reference for P1075, please let us know.
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Keywords: P1075, P1075 supplier, Potent, KATP, channel, openers, Potassium, KIR, Channels, Inward, Rectifier, K+, Kir6, rectifier, 1355, Tocris Bioscience
2 Citations for P1075
Citations are publications that use Tocris products. Selected citations for P1075 include:
Cao et al (2005) KATP channel conductance of descending vasa recta pericytes. Am J Physiol Renal Physiol 289 F1235 PMID: 16048905
Baczkó et al (2005) Plasma membrane KATP channel-mediated cardioprotection involves posthypoxic reductions in calcium overload and contractile dysfunction: mechanistic insights into cardioplegia. FASEB J 19 980 PMID: 15774423
Do you know of a great paper that uses P1075 from Tocris? Please let us know.
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Literature in this Area
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