Potent Kir6 (KATP) channel opener (EC50 for relaxation of rat aorta = 7.5 nM). Binds to SUR2A and SUR2B with high affinity (Kd values are 17 and 3 nM respectively).
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 50 mM in ethanol and to 100 mM in DMSO|
Preparing Stock Solutions
The following data is based on the product molecular weight 231.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.32 mL||21.62 mL||43.23 mL|
|5 mM||0.86 mL||4.32 mL||8.65 mL|
|10 mM||0.43 mL||2.16 mL||4.32 mL|
|50 mM||0.09 mL||0.43 mL||0.86 mL|
References are publications that support the biological activity of the product.
Ashcroft and Gribble (2000) New windows on the mechanism of action of KATP channel openers. TiPS 21 439 PMID: 11121575
Buckner et al (2000) Pharmacological and molecular analysis of ATP-sensitive K+ channels in the pig and human detrusor. Eur.J.Pharmacol. 400 287 PMID: 10988346
Gross et al (1999) Stoichiometry of potassium channel opener action. Mol.Pharmacol. 56 1370 PMID: 10570067
Higdon et al (1997) Tissue and species variation in the vascular receptor binding of 3H-P1075, a potent KATP opener vasodilator. J.Pharmacol.Exp.Ther. 280 255 PMID: 8996204
If you know of a relevant reference for P1075, please let us know.
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Keywords: P1075, P1075 supplier, Potent, KATP, channel, openers, Potassium, KIR, Channels, Inward, Rectifier, K+, Kir6, rectifier, 1355, Tocris Bioscience
2 Citations for P1075
Citations are publications that use Tocris products. Selected citations for P1075 include:
Cao et al (2005) KATP channel conductance of descending vasa recta pericytes. Am J Physiol Renal Physiol 289 F1235 PMID: 16048905
Baczkó et al (2005) Plasma membrane KATP channel-mediated cardioprotection involves posthypoxic reductions in calcium overload and contractile dysfunction: mechanistic insights into cardioplegia. FASEB J 19 980 PMID: 15774423
Do you know of a great paper that uses P1075 from Tocris? Please let us know.
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Literature in this Area
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