Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewSelective inhibitor of ubiquitin-specific protease (USP) 7 (IC50 = 4.2 μM). Displays little-to-no inhibition of other USP variants or proteases such as caspase, cathepsins and serine proteases; exhibits some activity at USP47. Induces elevated p53 and apoptosis in cancer cell lines; displays antiangiogenic activity in vivo.
M. Wt | 348.22 |
Formula | C12H7Cl2NO3S2 |
Storage | Store at +4°C |
Purity | ≥99% (HPLC) |
CAS Number | 882257-11-6 |
PubChem ID | 2819993 |
InChI Key | LKZLGMAAKNEGCH-UHFFFAOYSA-N |
Smiles | CC(=O)C1=CC(=C(SC2=CC=CC(Cl)=C2Cl)S1)[N+]([O-])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 3.48 | 10 |
The following data is based on the product molecular weight 348.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 28.72 mL | 143.59 mL | 287.17 mL |
0.5 mM | 5.74 mL | 28.72 mL | 57.43 mL |
1 mM | 2.87 mL | 14.36 mL | 28.72 mL |
5 mM | 0.57 mL | 2.87 mL | 5.74 mL |
References are publications that support the biological activity of the product.
Weinstock et al (2012) Selective dual inhibitors of the cancer-related deubiquitylating proteases USP7 and USP47. J.Med.Chem. 3 789
Chauhan et al (2012) A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes borte. resistance. Cancer Cell. 22 345 PMID: 22975377
If you know of a relevant reference for P005091, please let us know.
Keywords: P005091, P005091 supplier, ubiquitin-specific, protease, USP7, inhibitors, inhibits, antiangiogenesis, antiangiogenic, apoptosis, p53, Antiangiogenics, Deubiquitinating, Enzymes, 4733, Tocris Bioscience
Citations are publications that use Tocris products.
Currently there are no citations for P005091. Do you know of a great paper that uses P005091 from Tocris? Please let us know.
There are currently no reviews for this product. Be the first to review P005091 and earn rewards!
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Our new product guide highlights over 215 new products added to the Tocris Bioscience range during the first half of 2019.