P005091

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Cat.No. 4733 - P005091 | C12H7Cl2NO3S2 | CAS No. 882257-11-6
Description: USP7 inhibitor
Chemical Name: 1-[5-[(2,3-Dichlorophenyl)thio]-4-nitro-2-thienyl]ethanone
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for P005091

P005091 is a selective inhibitor of ubiquitin-specific protease (USP) 7 (IC50 = 4.2 μM). Displays little-to-no inhibition of other USP variants or proteases such as caspase, cathepsins and serine proteases; exhibits some activity at USP47. Induces elevated p53 and apoptosis in cancer cell lines; displays antiangiogenic activity in vivo.

Technical Data for P005091

M. Wt 348.22
Formula C12H7Cl2NO3S2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 882257-11-6
PubChem ID 2819993
InChI Key LKZLGMAAKNEGCH-UHFFFAOYSA-N
Smiles CC(=O)C1=CC(=C(SC2=CC=CC(Cl)=C2Cl)S1)[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for P005091

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.48 10

Preparing Stock Solutions for P005091

The following data is based on the product molecular weight 348.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 28.72 mL 143.59 mL 287.17 mL
0.5 mM 5.74 mL 28.72 mL 57.43 mL
1 mM 2.87 mL 14.36 mL 28.72 mL
5 mM 0.57 mL 2.87 mL 5.74 mL

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References for P005091

References are publications that support the biological activity of the product.

Weinstock et al (2012) Selective dual inhibitors of the cancer-related deubiquitylating proteases USP7 and USP47. J.Med.Chem. 3 789

Chauhan et al (2012) A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes borte. resistance. Cancer Cell. 22 345 PMID: 22975377


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Keywords: P005091, P005091 supplier, ubiquitin-specific, protease, USP7, inhibitors, inhibits, antiangiogenesis, antiangiogenic, apoptosis, p53, Antiangiogenics, Deubiquitinating, Enzymes, 4733, Tocris Bioscience

Citations for P005091

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