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Biological Activity for P005091
P005091 is a selective inhibitor of ubiquitin-specific protease (USP) 7 (IC50 = 4.2 μM). Displays little-to-no inhibition of other USP variants or proteases such as caspase, cathepsins and serine proteases; exhibits some activity at USP47. Induces elevated p53 and apoptosis in cancer cell lines; displays antiangiogenic activity in vivo.
Technical Data for P005091
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for P005091
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for P005091
The following data is based on the product molecular weight 348.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||28.72 mL||143.59 mL||287.17 mL|
|0.5 mM||5.74 mL||28.72 mL||57.43 mL|
|1 mM||2.87 mL||14.36 mL||28.72 mL|
|5 mM||0.57 mL||2.87 mL||5.74 mL|
References for P005091
References are publications that support the biological activity of the product.
Weinstock et al (2012) Selective dual inhibitors of the cancer-related deubiquitylating proteases USP7 and USP47. J.Med.Chem. 3 789
Chauhan et al (2012) A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes borte. resistance. Cancer Cell. 22 345 PMID: 22975377
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Keywords: P005091, P005091 supplier, ubiquitin-specific, protease, USP7, inhibitors, inhibits, antiangiogenesis, antiangiogenic, apoptosis, p53, Antiangiogenics, Deubiquitinating, Enzymes, 4733, Tocris Bioscience
Citations for P005091
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