Discontinued Product

P005091 (Cat. No. 4733) has been withdrawn from sale for commercial reasons.
Description: USP7 inhibitor
Chemical Name: 1-[5-[(2,3-Dichlorophenyl)thio]-4-nitro-2-thienyl]ethanone
Purity: ≥99% (HPLC)

Biological Activity for P005091

P005091 is a selective inhibitor of ubiquitin-specific protease (USP) 7 (IC50 = 4.2 μM). Displays little-to-no inhibition of other USP variants or proteases such as caspase, cathepsins and serine proteases; exhibits some activity at USP47. Induces elevated p53 and apoptosis in cancer cell lines; displays antiangiogenic activity in vivo.

Technical Data for P005091

M. Wt 348.22
Formula C12H7Cl2NO3S2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 882257-11-6
PubChem ID 2819993
Smiles CC(=O)C1=CC(=C(SC2=CC=CC(Cl)=C2Cl)S1)[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for P005091

References are publications that support the biological activity of the product.

Weinstock et al (2012) Selective dual inhibitors of the cancer-related deubiquitylating proteases USP7 and USP47. J.Med.Chem. 3 789

Chauhan et al (2012) A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes borte. resistance. Cancer Cell. 22 345 PMID: 22975377

View Related Products by Product Action

View all Deubiquitinating Enzyme Inhibitors

Keywords: P005091, P005091 supplier, ubiquitin-specific, protease, USP7, inhibitors, inhibits, antiangiogenesis, antiangiogenic, apoptosis, p53, Antiangiogenics, Deubiquitinating, Enzymes, 4733, Tocris Bioscience

Citations for P005091

Citations are publications that use Tocris products.

Currently there are no citations for P005091.

Reviews for P005091

There are currently no reviews for this product. Be the first to review P005091 and earn rewards!

Have you used P005091?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review