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Partial α2A adrenoceptor agonist and α1A agonist. Agonist/antagonist activity at 5-HT receptors.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 50 mM in water|
References are publications that support the biological activity of the product.
Bayorh et al (1997) Cardiovascular effects of oxymetazoline and UK14,304 in conscious and pithed rats. Clin.Exp.Hypertens. 19 445 PMID: 9140707
Horie et al (1995) Selectivity of the imidazoline α-adrenoceptor agonists (oxymetazoline and cirazoline) for human cloned α1-adrenoceptor subtypes. Br.J.Pharmacol. 116 1611 PMID: 8564227
Schoeffter et al (1991) Interaction of the α-adrenoceptor agonist oxymetazoline with serotonin 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptors. Eur.J.Pharmacol. 196 213 PMID: 1678720
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Keywords: Oxymetazoline hydrochloride, Oxymetazoline hydrochloride supplier, α1A-adrenoceptor, alpha1A-adrenoceptor, a1a-adrenoceptor, agonists, alpha2A-adrenoceptor, a2a-adrenoceptor, partial, α1-adrenergic, alpha1-adrenergic, a1-Adrenergic, alpha2a-Adrenergic, a2a-Adrenergic, Receptors, Adrenergic, Alpha-1, Alpha-2, 1142, Tocris Bioscience
2 Citations for Oxymetazoline hydrochloride
Citations are publications that use Tocris products. Selected citations for Oxymetazoline hydrochloride include:
Montgomery (2017) An Alpha-1A Adrenergic Receptor Agonist Prevents Acute dox. Cardiomyopathy in Male Mice. Plos One 12 e0168409 PMID: 28081170
Schihada et al (2018) A universal bioluminescence resonance energy transfer sensor design enables high-sensitivity screening of GPCR activation dynamics. Commun Biol 1 105 PMID: 30271985
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.