Oxymetazoline hydrochloride

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Cat.No. 1142 - Oxymetazoline hydrochloride | C16H24N2O.HCl | CAS No. 2315-02-8
Description: α1A agonist
Chemical Name: 3-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethyl-phenol hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (4)

Biological Activity

Partial α2A adrenoceptor agonist and α1A agonist. Agonist/antagonist activity at 5-HT receptors.

Technical Data

M. Wt 296.84
Formula C16H24N2O.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 2315-02-8
PubChem ID 66259
InChI Key BEEDODBODQVSIM-UHFFFAOYSA-N
Smiles Cl.CC1=C(CC2=NCCN2)C(C)=C(O)C(=C1)C(C)(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 50 mM in water

References

References are publications that support the biological activity of the product.

Bayorh et al (1997) Cardiovascular effects of oxymetazoline and UK14,304 in conscious and pithed rats. Clin.Exp.Hypertens. 19 445 PMID: 9140707

Horie et al (1995) Selectivity of the imidazoline α-adrenoceptor agonists (oxymetazoline and cirazoline) for human cloned α1-adrenoceptor subtypes. Br.J.Pharmacol. 116 1611 PMID: 8564227

Schoeffter et al (1991) Interaction of the α-adrenoceptor agonist oxymetazoline with serotonin 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptors. Eur.J.Pharmacol. 196 213 PMID: 1678720


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2 Citations for Oxymetazoline hydrochloride

Citations are publications that use Tocris products. Selected citations for Oxymetazoline hydrochloride include:

Montgomery (2017) An Alpha-1A Adrenergic Receptor Agonist Prevents Acute dox. Cardiomyopathy in Male Mice. Plos One 12 e0168409 PMID: 28081170

Schihada et al (2018) A universal bioluminescence resonance energy transfer sensor design enables high-sensitivity screening of GPCR activation dynamics. Commun Biol 1 105 PMID: 30271985


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Literature in this Area

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