Orexin A (human, rat, mouse)

Pricing Availability   Qty
Description: Endogenous agonist at OX1 and OX2
Purity: ≥95% (HPLC)
Datasheet
Citations (11)
Reviews (1)
Literature (1)

Biological Activity for Orexin A (human, rat, mouse)

Orexin A (human, rat, mouse) is an endogenous agonist with high affinity at orexin receptors (Ki values are 20 and 38 nM for OX1 and OX2 receptors respectively). Orexin A stimulates feeding following central administration and may be involved in the control of sleep-wake cycle and other hypothalamic functions. Orexin A impairs neurogenesis and hippocampal plasticity in mice. Orexin A improves glucose control and beta cell functions in type 2 diabetic animals.

Technical Data for Orexin A (human, rat, mouse)

M. Wt 3561.12
Formula C152H243N47O44S4
Sequence XPLPDCCRQKTCSCRLYELLHGAGNHAAGILTL

(Modifications: X = Glp, Disulfide bridges: 6-12, 7-14, Leu-33 = C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 205640-90-0
PubChem ID 90470982
InChI Key IXODJSWYPSZUCI-IIIOAANCSA-N
Smiles [H]N1[C@@H](CCC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC2=CC=C(O)C=C2)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC2=CNC=N2)C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC2=CNC=N2)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(N)=O)NC1=O)[C@@H](C)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Orexin A (human, rat, mouse)

Solubility Soluble to 1 mg/ml in water

Product Datasheets for Orexin A (human, rat, mouse)

Certificate of Analysis / Product Datasheet
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References for Orexin A (human, rat, mouse)

References are publications that support the biological activity of the product.

Kilduff and Peyron (2000) The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders. TiNS 23 359 PMID: 10906799

Sakurai et al (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour. Cell 92 573 PMID: 9491897

Smart (1999) Orexins: a new family of neuropeptides. Br.J.Anaesth. 83 695 PMID: 10690128

Forte et al (2021) Orexin-A and endocannabinoids are involved in obesity-associated alteration of hippocampal neurogenesis, plasticity, and episodic memory in mice. Nat.Commun. 12 6137 PMID: 34675233

Kaczmarek et al (2017) Chronic orexin-A (hypocretin-1) treatment of type 2 diabetic rats improves glucose control and beta-cell functions. J.Physiol.Pharmacol. 68 669 PMID: 29375041


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Keywords: Orexin A (human, rat, mouse), Orexin A (human, rat, mouse) supplier, Endogenous, agonists, OX1, OX2, Orexin, Non-Selective, Receptors, OrexinA, (human, rat, mouse), Non-selective, 1455, Tocris Bioscience

11 Citations for Orexin A (human, rat, mouse)

Citations are publications that use Tocris products. Selected citations for Orexin A (human, rat, mouse) include:

Kim et al (2015) Involvement of Heme Oxygenase-1 in Orexin-A-induced Angiogenesis in Vascular Endothelial Cells. Brain Res 19 327 PMID: 26170736

Forte et al (2021) Orexin-A and endocannabinoids are involved in obesity-associated alteration of hippocampal neurogenesis, plasticity, and episodic memory in mice. Nat.Commun. 12 6137 PMID: 34675233

Gompf and Aston-Jones (2008) Role of orexin input in the diurnal rhythm of locus coeruleus impulse activity. J Pharmacol Exp Ther 1224 43 PMID: 18614159

Kim and Han (2016) Functional Connectivity of Basolateral Amygdala Neurons Carrying Orexin Receptors and Melanin-concentrating Hormone Receptors in Regulating Sociability and Mood-related Behaviors. Exp Neurobiol 25 307 PMID: 28035181


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Reviews for Orexin A (human, rat, mouse)

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ICV injection in rats.
By Chris Holton on 05/31/2020
Assay Type: In Vivo
Species: Rat

ICV injection of orexin A at 20, 63 and 600 pmol in 2 uL aCSF in male Sprague Dawley rats under propofol anesthesia. Measurement of extracellular neuronal cell firing from the locus coeruleus. Clonidine 0.1 mg/kg i.p.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.