Orexin A (human, rat, mouse)

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Cat.No. 1455 - Orexin A (human, rat, mouse) | Glp-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2 (Disulfide bridge: 6-12 and 7-14) | CAS No. 205640-90-0
Description: Endogenous agonist at OX1 and OX2
Datasheet
Citations (10)
Reviews
Literature

Biological Activity

Endogenous agonist at orexin receptors (Ki values are 20 and 38 nM for OX1 and OX2 receptors respectively). Stimulates feeding following central administration and may be involved in the control of sleep-wake cycle and other hypothalamic functions.

Technical Data

M. Wt 3561.12
Formula C152H243N47O44S4
Sequence XPLPDCCRQKTCSCRLYELLHGAGNHAAGILTL

(Modifications: X = Glp, Disulfide bridge between 6 - 12, 7 - 14, Leu-33 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 205640-90-0
PubChem ID 90470982
InChI Key IXODJSWYPSZUCI-IIIOAANCSA-N
Smiles [H]N1[C@@H](CCC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC2=CC=C(O)C=C2)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC2=CNC=N2)C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC2=CNC=N2)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(N)=O)NC1=O)[C@@H](C)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Kilduff and Peyron (2000) The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders. TiNS 23 359 PMID: 10906799

Sakurai et al (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour. Cell 92 573 PMID: 9491897

Smart (1999) Orexins: a new family of neuropeptides. Br.J.Anaesth. 83 695 PMID: 10690128


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Keywords: Orexin A (human, rat, mouse), Orexin A (human, rat, mouse) supplier, Endogenous, agonists, OX1, OX2, Orexin, Non-Selective, Receptors, OrexinA, (human, rat, mouse), Non-selective, 1455, Tocris Bioscience

10 Citations for Orexin A (human, rat, mouse)

Citations are publications that use Tocris products. Selected citations for Orexin A (human, rat, mouse) include:

Gompf and Aston-Jones (2008) Role of orexin input in the diurnal rhythm of locus coeruleus impulse activity. J Pharmacol Exp Ther 1224 43 PMID: 18614159

Kim and Han (2016) Functional Connectivity of Basolateral Amygdala Neurons Carrying Orexin Receptors and Melanin-concentrating Hormone Receptors in Regulating Sociability and Mood-related Behaviors. Exp Neurobiol 25 307 PMID: 28035181

Kim et al (2015) Involvement of Heme Oxygenase-1 in Orexin-A-induced Angiogenesis in Vascular Endothelial Cells. Brain Res 19 327 PMID: 26170736

Shu et al (2014) Orexin-A promotes cell migration in cultured rat astrocytes via Ca2+-dependent PKCα and ERK1/2 signals. PLoS One 9 e95259 PMID: 24748172

Guo and Feng (2012) OX2R activation induces PKC-mediated ERK and CREB phosphorylation. Exp Cell Res 318 2004 PMID: 22652455

Moorman and Aston-Jones (2010) Orexin/hypocretin modulates response of ventral tegmental DA neurons to prefrontal activation: diurnal influences. J Neurosci 30 15585 PMID: 21084614

Holland et al (2005) Orexin 1 receptor activation attenuates neurogenic dural vasodilation in an animal model of trigeminovascular nociception. Korean J Physiol Pharmacol 315 1380 PMID: 16160082

Burdyga et al (2010) Expression of cannabinoid CB1 receptors by vagal afferent neurons: kinetics and role in influencing neurochemical phenotype. Am J Physiol Gastrointest Liver Physiol 299 G63 PMID: 20430875

Khoo et al (2017) The dual orexin receptor antagonist TCS1102 does not affect reinstatement of nicotine-seeking. PLoS One 12 PMID: 28296947

Lungwitz et al (2012) Orexin-A induces anxiety-like behavior through interactions with glutamatergic receptors in the bed nucleus of the stria terminalis of rats. Physiol Behav 107 726 PMID: 22652097


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