Orexin A (human, rat, mouse)

Pricing Availability   Qty
Cat.No. 1455 - Orexin A (human, rat, mouse) | Glp-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2 (Disulfide bridge: 6-12 and 7-14) | CAS No. 205640-90-0
Description: Endogenous agonist at OX1 and OX2
Datasheet
Citations (10)
Reviews (1)
Literature (3)

Biological Activity

Endogenous agonist at orexin receptors (Ki values are 20 and 38 nM for OX1 and OX2 receptors respectively). Stimulates feeding following central administration and may be involved in the control of sleep-wake cycle and other hypothalamic functions.

Technical Data

M. Wt 3561.12
Formula C152H243N47O44S4
Sequence XPLPDCCRQKTCSCRLYELLHGAGNHAAGILTL

(Modifications: X = Glp, Disulfide bridge between 6 - 12, 7 - 14, Leu-33 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 205640-90-0
PubChem ID 90470982
InChI Key IXODJSWYPSZUCI-IIIOAANCSA-N
Smiles [H]N1[C@@H](CCC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC2=CC=C(O)C=C2)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC2=CNC=N2)C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC2=CNC=N2)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(N)=O)NC1=O)[C@@H](C)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Kilduff and Peyron (2000) The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders. TiNS 23 359 PMID: 10906799

Sakurai et al (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour. Cell 92 573 PMID: 9491897

Smart (1999) Orexins: a new family of neuropeptides. Br.J.Anaesth. 83 695 PMID: 10690128


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Keywords: Orexin A (human, rat, mouse), Orexin A (human, rat, mouse) supplier, Endogenous, agonists, OX1, OX2, Orexin, Non-Selective, Receptors, OrexinA, (human, rat, mouse), Non-selective, 1455, Tocris Bioscience

10 Citations for Orexin A (human, rat, mouse)

Citations are publications that use Tocris products. Selected citations for Orexin A (human, rat, mouse) include:

Shu et al (2014) Orexin-A promotes cell migration in cultured rat astrocytes via Ca2+-dependent PKCα and ERK1/2 signals. PLoS One 9 e95259 PMID: 24748172

Guo and Feng (2012) OX2R activation induces PKC-mediated ERK and CREB phosphorylation. Exp Cell Res 318 2004 PMID: 22652455

Moorman and Aston-Jones (2010) Orexin/hypocretin modulates response of ventral tegmental DA neurons to prefrontal activation: diurnal influences. J Neurosci 30 15585 PMID: 21084614

Khoo et al (2017) The dual orexin receptor antagonist TCS1102 does not affect reinstatement of nicotine-seeking. PLoS One 12 PMID: 28296947


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Reviews for Orexin A (human, rat, mouse)

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ICV injection in rats.
By Chris Holton on 05/31/2020
Assay Type: In Vivo
Species: Rat

ICV injection of orexin A at 20, 63 and 600 pmol in 2 uL aCSF in male Sprague Dawley rats under propofol anesthesia. Measurement of extracellular neuronal cell firing from the locus coeruleus. Clonidine 0.1 mg/kg i.p.

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