OXA 06 dihydrochloride

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Cat.No. 5182 - OXA 06 dihydrochloride | C21H18FN3.2HCl
Description: Potent ROCK inhibitor
Chemical Name: 2-Fluoro-N-[[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)phenyl]methyl]benzenemethanamine dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent ROCK inhibitor (IC50 = 10 nM). Suppresses pMYPT1 and pCofilin levels in non-small cell lung carcinoma (NSCLC) cell lines. Also inhibits anchorage-independent growth of NSCLC cell lines in vitro.

Compound Libraries

OXA 06 dihydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox II. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 404.31
Formula C21H18FN3.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
PubChem ID 91691120
InChI Key ZRBCUSMZOWMVJS-UHFFFAOYSA-N
Smiles FC1=CC=CC=C1CNCC(C=C4)=CC=C4C2=C3C(NC=C3)=NC=C2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.43 100

Preparing Stock Solutions

The following data is based on the product molecular weight 404.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.47 mL 12.37 mL 24.73 mL
5 mM 0.49 mL 2.47 mL 4.95 mL
10 mM 0.25 mL 1.24 mL 2.47 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Vigil et al (2012) ROCK1 and ROCK2 are required for non-small cell lung cancer anchorage-independent growth and invasion. Cancer Res. 72 5338 PMID: 22942252


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Keywords: OXA 06 dihydrochloride, supplier, OXA06, dihydrochloride, rho, kinases, ROCK, potent, inhibitors, inhibits, 944955_32_2, Rho-kinases, Rho-kinases, Tocris Bioscience

Citations for OXA 06 dihydrochloride

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