OSU 6162 hydrochloride

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Cat.No. 2599 - OSU 6162 hydrochloride | C15H23NO2S.HCl | CAS No. 156907-84-5
Description: Dopamine stabilizer
Alternative Names: PNU 96391
Chemical Name: (3S)-3-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine hydrochloride
Purity: ≥98% (HPLC)

Biological Activity

Dopamine stabilizer; lacks high affinity for various neuroreceptors in vitro (Ki values are 447 and 1305 nM for D2 and D3 receptors respectively and > 1 μM for other targets). Exhibits high D2 receptor occupancy in vivo; highly active on dopamine synthesis and turnover. Induces stabilizing effects on psychomotor function in behavioral tests without inducing hypolocomotion or catalepsy.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 317.87
Formula C15H23NO2S.HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 156907-84-5
PubChem ID 9836644
Smiles CCCN(C2)CCC[C@@]2([H])C1=CC=CC(S(=O)(C)=O)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 31.79 100
water 31.79 100

Preparing Stock Solutions

The following data is based on the product molecular weight 317.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.15 mL 15.73 mL 31.46 mL
5 mM 0.63 mL 3.15 mL 6.29 mL
10 mM 0.31 mL 1.57 mL 3.15 mL
50 mM 0.06 mL 0.31 mL 0.63 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Nichols et al (2002) PNU-96391A (OSU6162) antagonizes the development of behavioural sensitization induced by dopamine agonists in a rat model for Parkinson's disease. Neuropharmacology 43 817 PMID: 12384167

Natesan et al (2006) The dopamine stabilizers (S)-(-)-(3-methanesulfonyl-phenyl)-1-propyl-piperidine [(-)-OSU6162] and 4-(3-methanesulfonyl-phenyl)-1-propyl-piperidine (ACR16) show high in vivo D2 receptor occupancy, antipsychotic-like efficacy, and low po J.Pharmacol.Exp.Ther. 318 810 PMID: 16648369

Rung et al (2005) The dopaminergic stabilizers (-)-OSU6162 and ACR16 reverse (+)-MK-801-induced social withdrawal in rats. Prog.Neuro-Psychopharm.Biol.Psychiat. 29 833 PMID:

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