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High affinity NLRP3 inflammasome inhibitor (Kd = 52.5 nM). Forms covalent bind within NACHT domain and blocks interaction of NLRP3 with NEK7 to inhibit assembly and activation of inflammasome. Inhibits glial activation, decreases inflammatory cytokine release, attenuates synaptic loss and improves behavioural deficits in Aβ1-42 treated mice. Also displays anti-cancer properties in various cancer cell lines.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 364.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.74 mL||13.72 mL||27.44 mL|
|5 mM||0.55 mL||2.74 mL||5.49 mL|
|10 mM||0.27 mL||1.37 mL||2.74 mL|
|50 mM||0.05 mL||0.27 mL||0.55 mL|
References are publications that support the biological activity of the product.
Wang et al (2014) Oridonin attenuates Aβ1-42-induced neuroinflammation and inhibits NF-κB pathway. PLoS One 9 e104745 PMID: 25121593
Wang et al (2016) Oridonin attenuates synaptic loss and cognitive deficits in an Aβ1-42-induced mouse model of alzheimer's disease. PLoS One 11 e0151397 PMID: 26974541
He et al (2018) Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity. Nat.Commun. 9 2550 PMID: 29959312
Wang et al (2017) Oridonin induces G2/M cell cycle arrest and apoptosis in human oral squamous cell carcinoma. Eur.J.Pharmacol. 815 282 PMID: 28935563
Yao et al (2017) Oridonin induces autophagy via inhibition of glucose metabolism in p53-mutated colorectal cancer cells. Cell Death Dis. 8 e2633 PMID: 28230866
If you know of a relevant reference for Oridonin, please let us know.
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Keywords: Oridonin, Oridonin supplier, oridonin, NLRP3, inflammasome, inhibitors, inhibits, covalent, anti-cancer, anti-inflammatory, Inflammasomes, 6924, Tocris Bioscience
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