Oridonin

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Cat.No. 6924 - Oridonin | C20H28O6 | CAS No. 28957-04-2
Description: High affinity NLRP3 inflammasome inhibitor
Chemical Name: 7α,20-Epoxy-1α,6β,7,14-tetrahydroxykaur-16-en-15-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (4)

Biological Activity

High affinity NLRP3 inflammasome inhibitor (Kd = 52.5 nM). Forms covalent bind within NACHT domain and blocks interaction of NLRP3 with NEK7 to inhibit assembly and activation of inflammasome. Inhibits glial activation, decreases inflammatory cytokine release, attenuates synaptic loss and improves behavioural deficits in Aβ1-42 treated mice. Also displays anti-cancer properties in various cancer cell lines.

Technical Data

M. Wt 364.44
Formula C20H28O6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 28957-04-2
PubChem ID 5321010
InChI Key SDHTXBWLVGWJFT-XKCURVIJSA-N
Smiles O=C1[C@@]23[C@@]4(O)[C@@H](O)[C@]5([H])C(C)(C)CC[C@H](O)[C@@]5(CO4)[C@]2([H])CC[C@H]([C@H]3O)C1=C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.44 100
ethanol 36.44 100

Preparing Stock Solutions

The following data is based on the product molecular weight 364.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.74 mL 13.72 mL 27.44 mL
5 mM 0.55 mL 2.74 mL 5.49 mL
10 mM 0.27 mL 1.37 mL 2.74 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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References

References are publications that support the biological activity of the product.

Wang et al (2014) Oridonin attenuates Aβ1-42-induced neuroinflammation and inhibits NF-κB pathway. PLoS One 9 e104745 PMID: 25121593

Wang et al (2016) Oridonin attenuates synaptic loss and cognitive deficits in an Aβ1-42-induced mouse model of alzheimer's disease. PLoS One 11 e0151397 PMID: 26974541

He et al (2018) Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity. Nat.Commun. 9 2550 PMID: 29959312

Wang et al (2017) Oridonin induces G2/M cell cycle arrest and apoptosis in human oral squamous cell carcinoma. Eur.J.Pharmacol. 815 282 PMID: 28935563

Yao et al (2017) Oridonin induces autophagy via inhibition of glucose metabolism in p53-mutated colorectal cancer cells. Cell Death Dis. 8 e2633 PMID: 28230866


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Keywords: Oridonin, Oridonin supplier, oridonin, NLRP3, inflammasome, inhibitors, inhibits, covalent, anti-cancer, anti-inflammatory, Inflammasomes, 6924, Tocris Bioscience

Citations for Oridonin

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Literature in this Area

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