Org 37684

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Cat.No. 4797 - Org 37684 | C14H19NO2.HCl | CAS No. 213007-95-5
Description: 5-HT2 agonist
Chemical Name: (3S)-3-[(2,3--Dihydro-5-methoxy-1H-inden-4-yl)oxy]pyrrolidine hydrochloride
Datasheet
Citations
Literature

Biological Activity

Agonist of 5-HT2 receptors. Exhibits a rank order of potency of 5-HT2C >5-HT2B >5-HT2A (pEC50 values are 8.17, 7.96 and 7.11 respectively, in transfected CHO-K1 cells).

Technical Data

M. Wt 269.77
Formula C14H19NO2.HCl
Storage Desiccate at RT
CAS Number 213007-95-5
PubChem ID 9881884
InChI Key KJEAKWPQCIAVGR-MERQFXBCSA-N
Smiles COC1=CC=C(CCC3)C3=C1O[C@H]2CCNC2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.98 100
ethanol 26.98 100
water 13.49 50

Preparing Stock Solutions

The following data is based on the product molecular weight 269.77. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.71 mL 18.53 mL 37.07 mL
5 mM 0.74 mL 3.71 mL 7.41 mL
10 mM 0.37 mL 1.85 mL 3.71 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

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References

References are publications that support the products' biological activity.

Porter et al (1999) Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells. Br.J.Pharmacol. 128 13 PMID: 10498829

De Vry and Schreiber (2000) Effects of selected serotonin 5-HT1 and 5-HT2 receptor agonists on feeding behavior: possible mechanisms of action. Neurosci.Biobehav.Rev. 24 341 PMID: 10781694


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Keywords: Org37684 5-HT2 5-HT2C agonists serotonergic serotonin Non-selective 5-HT2

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GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

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5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

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