Org 12962 hydrochloride

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Cat.No. 3585 - Org 12962 hydrochloride | C10H11ClF3N3.HCl | CAS No. 210821-63-9
Description: Selective 5-HT2C agonist
Chemical Name: 1-[6-Chloro-5-trifluoromethyl)-2-pyridinyl]-piperazine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective 5-HT2C receptor agonist (pEC50 values are 7.01, 6.38 and 6.28 for 5-HT2C, 5-HT2A and 5-HT2B respectively). Displays antiaversive effects in a rat model of panic-like anxiety.

Technical Data

M. Wt 302.12
Formula C10H11ClF3N3.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 210821-63-9
PubChem ID 9796407
InChI Key FVDILXYXZAAJOS-UHFFFAOYSA-N
Smiles ClC1=NC(N2CCNCC2)=CC=C1C(F)(F)F.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.21 100
water 15.11 50

Preparing Stock Solutions

The following data is based on the product molecular weight 302.12. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.31 mL 16.55 mL 33.1 mL
5 mM 0.66 mL 3.31 mL 6.62 mL
10 mM 0.33 mL 1.65 mL 3.31 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Jenck et al (1998) Antiaversive effects of 5-HT2C receptor agonists and fluoxetine in a model of panic-like anxiety in rats. Eur.Neuropsychopharmacol. 8 161 PMID: 9716307

Porter et al (1999) Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells. Br.J.Pharmacol. 128 13 PMID: 10498829

Halford et al (2005) Serotonin (5-HT) drugs: effects on appetite expression and use for the treatment of obesity. Curr.Drug Targets 6 201 PMID: 15777190


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