Org 12962 hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 3585 - Org 12962 hydrochloride | C10H11ClF3N3.HCl | CAS No. 210821-63-9
Description: Selective 5-HT2C agonist
Chemical Name: 1-[6-Chloro-5-trifluoromethyl)-2-pyridinyl]-piperazine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective 5-HT2C receptor agonist (pEC50 values are 7.01, 6.38 and 6.28 for 5-HT2C, 5-HT2A and 5-HT2B respectively). Displays antiaversive effects in a rat model of panic-like anxiety.

Technical Data

M. Wt 302.12
Formula C10H11ClF3N3.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 210821-63-9
PubChem ID 9796407
InChI Key FVDILXYXZAAJOS-UHFFFAOYSA-N
Smiles ClC1=NC(N2CCNCC2)=CC=C1C(F)(F)F.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 15.11 50
DMSO 30.21 100

Preparing Stock Solutions

The following data is based on the product molecular weight 302.12. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.31 mL 16.55 mL 33.1 mL
5 mM 0.66 mL 3.31 mL 6.62 mL
10 mM 0.33 mL 1.65 mL 3.31 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Jenck et al (1998) Antiaversive effects of 5-HT2C receptor agonists and fluoxetine in a model of panic-like anxiety in rats. Eur.Neuropsychopharmacol. 8 161 PMID: 9716307

Porter et al (1999) Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells. Br.J.Pharmacol. 128 13 PMID: 10498829

Halford et al (2005) Serotonin (5-HT) drugs: effects on appetite expression and use for the treatment of obesity. Curr.Drug Targets 6 201 PMID: 15777190


If you know of a relevant reference for Org 12962 hydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all 5-HT2C Receptor Agonists

Keywords: Org 12962 hydrochloride, Org 12962 hydrochloride supplier, 5-HT2C, agonist, Serotonin, Receptors, 5-HT2, Org12962, hydrochloride, 3585, Tocris Bioscience

Citations for Org 12962 hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for Org 12962 hydrochloride. Do you know of a great paper that uses Org 12962 hydrochloride from Tocris? Please let us know.

Reviews for Org 12962 hydrochloride

There are currently no reviews for this product. Be the first to review Org 12962 hydrochloride and earn rewards!

Have you used Org 12962 hydrochloride?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Depression

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Parkinson's

Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.