Optovin

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Description: Reversible photoactive TRPA1 activator
Chemical Name: 5-[[2,5-Dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-2-thioxo-4-thiazolidinone
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews

Biological Activity for Optovin

Optovin is a reversible photoactive TRPA1 activator. Stimulates human TRPA1 channels in vitro and enables repeated photoactivation of motor behaviors in wild-type zebrafish (EC50 = 2 μM) and mice, in vivo.

Technical Data for Optovin

M. Wt 315.41
Formula C15H13N3OS2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 348575-88-2
PubChem ID 1365101
InChI Key YISGMOZSGOGYOU-NTUHNPAUSA-N
Smiles S=C(N2)S/C(C2=O)=C/C1=C(C)N(C3=CN=CC=C3)C(C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Optovin

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.54 100

Preparing Stock Solutions for Optovin

The following data is based on the product molecular weight 315.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.17 mL 15.85 mL 31.7 mL
5 mM 0.63 mL 3.17 mL 6.34 mL
10 mM 0.32 mL 1.59 mL 3.17 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

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References for Optovin

References are publications that support the biological activity of the product.

Kokel et al (2013) Photochemical activation of TRPA1 channels in neurons and animals. Nat.Chem.Biol. 9 257 PMID: 23396078


If you know of a relevant reference for Optovin, please let us know.

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Keywords: Optovin, Optovin supplier, photoactive, TRPA1, TRP, channels, activators, photoactivation, photoswitchable, Photoswitchable, Ligands, 4901, Tocris Bioscience

3 Citations for Optovin

Citations are publications that use Tocris products. Selected citations for Optovin include:

Jon et al (2021) Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways. Cell Host Microbe 29 179-196.e9 PMID: 33352109

Sandy et al (2022) Social isolation modulates appetite and avoidance behavior via a common oxytocinergic circuit in larval zebrafish. Nat Commun 13 2573 PMID: 35545618

James A et al (2019) Zebrafish oxytocin neurons drive nocifensive behavior via brainstem premotor targets. Nat Neurosci 22 1477-1492 PMID: 31358991


Do you know of a great paper that uses Optovin from Tocris? Please let us know.

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