Optovin

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Cat.No. 4901 - Optovin | C15H13N3OS2 | CAS No. 348575-88-2
Description: Reversible photoactive TRPA1 activator
Chemical Name: 5-[[2,5-Dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-2-thioxo-4-thiazolidinone
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Reversible photoactive TRPA1 activator. Stimulates human TRPA1 channels in vitro and enables repeated photoactivation of motor behaviors in wild-type zebrafish (EC50 = 2 μM) and mice, in vivo.

Technical Data

M. Wt 315.41
Formula C15H13N3OS2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 348575-88-2
PubChem ID 1365101
InChI Key YISGMOZSGOGYOU-NTUHNPAUSA-N
Smiles S=C(N2)S/C(C2=O)=C/C1=C(C)N(C3=CN=CC=C3)C(C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.54 100

Preparing Stock Solutions

The following data is based on the product molecular weight 315.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.17 mL 15.85 mL 31.7 mL
5 mM 0.63 mL 3.17 mL 6.34 mL
10 mM 0.32 mL 1.59 mL 3.17 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

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References

References are publications that support the biological activity of the product.

Kokel et al (2013) Photochemical activation of TRPA1 channels in neurons and animals. Nat.Chem.Biol. 9 257 PMID: 23396078


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Keywords: Optovin, Optovin supplier, photoactive, TRPA1, TRP, channels, activators, photoactivation, 4901, Tocris Bioscience

Citations for Optovin

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