Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewOptoBI-1
Description: Photoswitchable TRPC3/6/7 agonist
Chemical Name: 1-[1-[4-[4-[(4-Butylphenyl)diazenyl]phenyl]butanoyl]piperidin-4-yl]-1,3-dihydro-2H-benzo[d]imidazol-2-one
Purity: ≥98% (HPLC)
Biological Activity for OptoBI-1
OptoBI-1 is a photoswitchable TRPC3/6/7 agonist (EC50 for active cis-form ~0.1 μM at TRPC3). Switches conformation from trans to cis at 365 nm and cis to trans at 430 nm. Returns to trans conformation in the dark after ~ 50 minutes. No effect observed on TRPC4 or 5. Rapidly changes TRPC3 conductance and inhibits neuronal firing in cis-state.
Technical Data for OptoBI-1
| M. Wt | 523.67 |
| Formula | C32H37N5O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2415272-11-4 |
| InChI Key | LUASQYYRQCWOMA-XAHDOWKMSA-N |
| Smiles | CCCCC1=CC=C(/N=N/C2=CC=C(C=C2)CCCC(N3CCC(N4C(NC5=CC=CC=C45)=O)CC3)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for OptoBI-1
References for OptoBI-1
References are publications that support the biological activity of the product.
Tiapko et al (2019) Lipid-independent control of endothelial and neuronal TRPC3 channels by light. Chem.Sci. 10 2837
Curcic et al (2019) Photopharmacology and opto-chemogenetics of TRPC channels-some therapeutic visions. Pharmacol.Ther. 200 13 PMID: 30974125
Curcic et al (2019) TRPC-mediated Ca2+ signaling and control of cellular functions. Semin.Cell Dev.Biol. 94 28 PMID: 30738858
Lichtenegger et al (2018) An optically controlled probe identifies lipid-gating fenestrations within the TRPC3 channel. Nat.Chem.Biol. 14 396 PMID: 29556099
View Related Products by Target
Keywords: OptoBI-1, OptoBI-1 supplier, OptoBI1, PhotoswitchableTRPC3, TRPC6, TRPC7, agonists, agonism, ligands, Photoswitchable, Ligands, TRPC, 7013, Tocris Bioscience
Citations for OptoBI-1
Citations are publications that use Tocris products.
Currently there are no citations for OptoBI-1.
Reviews for OptoBI-1
There are currently no reviews for this product. Be the first to review OptoBI-1 and earn rewards!
Have you used OptoBI-1?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image