OptoBI-1

Pricing Availability   Qty
Cat.No. 7013 - OptoBI-1 | C32H37N5O2
Description: Photoswitchable TRPC3/6/7 agonist
Chemical Name: 1-[1-[4-[4-[(4-Butylphenyl)diazenyl]phenyl]butanoyl]piperidin-4-yl]-1,3-dihydro-2H-benzo[d]imidazol-2-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

Photoswitchable TRPC3/6/7 agonist (EC50 for active cis-form ~0.1 μM at TRPC3). Switches conformation from trans to cis at 365 nm and cis to trans at 430 nm. Returns to trans conformation in the dark after ~ 50 minutes. No effect observed on TRPC4 or 5. Rapidly changes TRPC3 conductance and inhibits neuronal firing in cis-state.

Technical Data

M. Wt 523.67
Formula C32H37N5O2
Storage Store at -20°C
Purity ≥98% (HPLC)
InChI Key LUASQYYRQCWOMA-XAHDOWKMSA-N
Smiles CCCCC1=CC=C(/N=N/C2=CC=C(C=C2)CCCC(N3CCC(N4C(NC5=CC=CC=C45)=O)CC3)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 5.24 10

Preparing Stock Solutions

The following data is based on the product molecular weight 523.67. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.1 mL 95.48 mL 190.96 mL
0.5 mM 3.82 mL 19.1 mL 38.19 mL
1 mM 1.91 mL 9.55 mL 19.1 mL
5 mM 0.38 mL 1.91 mL 3.82 mL

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References

References are publications that support the biological activity of the product.

Tiapko et al (2019) Lipid-independent control of endothelial and neuronal TRPC3 channels by light. Chem.Sci. 10 2837

Curcic et al (2019) Photopharmacology and opto-chemogenetics of TRPC channels-some therapeutic visions. Pharmacol.Ther. 200 13 PMID: 30974125

Curcic et al (2019) TRPC-mediated Ca2+ signaling and control of cellular functions. Semin.Cell Dev.Biol. 94 28 PMID: 30738858

Lichtenegger et al (2018) An optically controlled probe identifies lipid-gating fenestrations within the TRPC3 channel. Nat.Chem.Biol. 14 396 PMID: 29556099


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Keywords: OptoBI-1, OptoBI-1 supplier, OptoBI1, PhotoswitchableTRPC3, TRPC6, TRPC7, agonists, agonism, ligands, Photoswitchable, Ligands, TRPC, 7013, Tocris Bioscience

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Ion Channel

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