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Description: Photoswitchable TRPC3/6/7 agonist
Chemical Name: 1-[1-[4-[4-[(4-Butylphenyl)diazenyl]phenyl]butanoyl]piperidin-4-yl]-1,3-dihydro-2H-benzo[d]imidazol-2-one
Purity: ≥98% (HPLC)

Biological Activity for OptoBI-1

OptoBI-1 is a photoswitchable TRPC3/6/7 agonist (EC50 for active cis-form ~0.1 μM at TRPC3). Switches conformation from trans to cis at 365 nm and cis to trans at 430 nm. Returns to trans conformation in the dark after ~ 50 minutes. No effect observed on TRPC4 or 5. Rapidly changes TRPC3 conductance and inhibits neuronal firing in cis-state.

Technical Data for OptoBI-1

M. Wt 523.67
Formula C32H37N5O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2415272-11-4
Smiles CCCCC1=CC=C(/N=N/C2=CC=C(C=C2)CCCC(N3CCC(N4C(NC5=CC=CC=C45)=O)CC3)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for OptoBI-1

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 5.24 10

Preparing Stock Solutions for OptoBI-1

The following data is based on the product molecular weight 523.67. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.1 mL 95.48 mL 190.96 mL
0.5 mM 3.82 mL 19.1 mL 38.19 mL
1 mM 1.91 mL 9.55 mL 19.1 mL
5 mM 0.38 mL 1.91 mL 3.82 mL

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References for OptoBI-1

References are publications that support the biological activity of the product.

Tiapko et al (2019) Lipid-independent control of endothelial and neuronal TRPC3 channels by light. Chem.Sci. 10 2837

Curcic et al (2019) Photopharmacology and opto-chemogenetics of TRPC channels-some therapeutic visions. Pharmacol.Ther. 200 13 PMID: 30974125

Curcic et al (2019) TRPC-mediated Ca2+ signaling and control of cellular functions. Semin.Cell Dev.Biol. 94 28 PMID: 30738858

Lichtenegger et al (2018) An optically controlled probe identifies lipid-gating fenestrations within the TRPC3 channel. Nat.Chem.Biol. 14 396 PMID: 29556099

If you know of a relevant reference for OptoBI-1, please let us know.

Keywords: OptoBI-1, OptoBI-1 supplier, OptoBI1, PhotoswitchableTRPC3, TRPC6, TRPC7, agonists, agonism, ligands, Photoswitchable, Ligands, TRPC, 7013, Tocris Bioscience

Citations for OptoBI-1

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