ONO 4817

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Cat.No. 2628 - ONO 4817 | C22H28N2O6 | CAS No. 223472-31-9
Description: Broad spectrum MMP inhibitor
Chemical Name: N-[(1S,3S)-1-[(Ethoxymethoxy)methyl]-4-(hydroxyamino)-3-methyl-4-oxobutyl]-4-phenoxybenzamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Broad spectrum MMP inhibitor; Ki values are 0.45, 0.73, 1.1, 1.1, 2.1, 42 and 2500 nM for MMP-12, MMP-2, MMP-8, MMP-13, MMP-9, MMP-3 and MMP-7 respectively and IC50 = 1600 nM for MMP-1). Displays no activity at other proteases up to a concentration of 100 μM. Exhibits antiangiogenic and anti-invasive properties on lung metastasis of murine renal cell carcinoma.

Technical Data

M. Wt 416.47
Formula C22H28N2O6
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 223472-31-9
PubChem ID 9888141
InChI Key HDWWQELUBWGQGA-WMZOPIPTSA-N
Smiles O=C(N[C@H](COCOCC)C[C@H](C)C(NO)=O)C1=CC=C(OC2=CC=CC=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.65 100
ethanol 20.82 50

Preparing Stock Solutions

The following data is based on the product molecular weight 416.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.4 mL 12.01 mL 24.01 mL
5 mM 0.48 mL 2.4 mL 4.8 mL
10 mM 0.24 mL 1.2 mL 2.4 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Yamada et al (2000) ONO-4817, an orally active matrix metalloproteinase inhibitor, prevents lipopolysaccharide-induced proteoglycan release from the joint cartilage in guinea pigs. Inflamm.Res. 49 144 PMID: 10858013

Muraishi et al (2001) Effect of a matrix metalloproteinase inhibitor (ONO-4817) on lung metastasis of murine renal cell carcinoma. Anticancer Res. 21 3845 PMID: 11911256

Medina and Radomski (2006) Role of matrix metalloproteinases in intestinal inflammation. J.Pharmacol.Exp.Ther. 318 933 PMID: 16644899


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Citations for ONO 4817

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