ONO 2506

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Description: Inhibits S-100β synthesis; neuroprotective
Alternative Names: Arundic acid
Chemical Name: (2R)-2-Propyloctanoic acid
Citations (1)

Biological Activity for ONO 2506

ONO 2506 inhibits S-100β synthesis in activated cultured astrocytes. Prevents delayed infarct expansion 24 hours after permanent middle cerebral artery occlusion (pMCAO) in rats; also exhibits neuroprotective effects in mouse models of Parkinson's disease and Alzheimer's disease.

Technical Data for ONO 2506

M. Wt 186.29
Formula C11H22O2
Storage Store at +4°C
CAS Number 185517-21-9
PubChem ID 208925

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ONO 2506

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 18.63 100
ethanol 18.63 100

Preparing Stock Solutions for ONO 2506

The following data is based on the product molecular weight 186.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.37 mL 26.84 mL 53.68 mL
5 mM 1.07 mL 5.37 mL 10.74 mL
10 mM 0.54 mL 2.68 mL 5.37 mL
50 mM 0.11 mL 0.54 mL 1.07 mL

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Product Datasheets for ONO 2506

Certificate of Analysis / Product Datasheet
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References for ONO 2506

References are publications that support the biological activity of the product.

Kato et al (2004) Arundic acid, an astrocyte-modulating agent, protects DArgic neurons against MPTP neurotoxicity in mice. Brain Res. 1030 66 PMID: 15567338

Tateishi et al (2002) Astrocytic activation and delayed infarct expansion after permanent focal ischemia in rats. Part II: suppression of astrocytic activation by a novel agent (R)-(-)-2-propyloctanoic acid (ONO-2506) leads to mitigation of delayed infarct expansion and early J.Cereb.Blood Flow Metab. 22 723 PMID: 12045671

Mori et al (2006) Arundic acid ameliorates cerebral amyloidosis and gliosis in Alzheimer transgenic mice. J.Pharmacol.Exp.Ther. 318 571 PMID: 16709678

If you know of a relevant reference for ONO 2506, please let us know.

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1 Citation for ONO 2506

Citations are publications that use Tocris products. Selected citations for ONO 2506 include:

Hao et al (2017) Arundic Acid Prevents Developmental Upregulation of S100B Expression and Inhibits Enteric Glial Development. Front Cell Neurosci 11 42 PMID: 28280459

Do you know of a great paper that uses ONO 2506 from Tocris? Please let us know.

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