ONO 2506

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Cat.No. 4530 - ONO 2506 | C11H22O2 | CAS No. 185517-21-9
Description: Inhibits S-100β synthesis; neuroprotective
Alternative Names: Arundic acid
Chemical Name: (2R)-2-Propyloctanoic acid
Datasheet
Citations
Literature

Biological Activity

Inhibits S-100β synthesis in activated cultured astrocytes. Prevents delayed infarct expansion 24 hours after permanent middle cerebral artery occlusion (pMCAO) in rats; also exhibits neuroprotective effects in mouse models of Parkinson's disease and Alzheimer's disease.

Technical Data

M. Wt 186.29
Formula C11H22O2
Storage Store at +4°C
CAS Number 185517-21-9
PubChem ID 208925
InChI Key YCYMCMYLORLIJX-SNVBAGLBSA-N
Smiles CCC[C@H](CCCCCC)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 18.63 100
ethanol 18.63 100

Preparing Stock Solutions

The following data is based on the product molecular weight 186.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.37 mL 26.84 mL 53.68 mL
5 mM 1.07 mL 5.37 mL 10.74 mL
10 mM 0.54 mL 2.68 mL 5.37 mL
50 mM 0.11 mL 0.54 mL 1.07 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Kato et al (2004) Arundic acid, an astrocyte-modulating agent, protects dopaminergic neurons against MPTP neurotoxicity in mice. Brain Res. 1030 66 PMID: 15567338

Tateishi et al (2002) strocytic activation and delayed infarct expansion after permanent focal ischemia in rats. Part II: suppression of astrocytic activation by a novel agent (R)-(-)-2-propyloctanoic acid (ONO-2506) leads to mitigation of delayed infarct expansion and early J.Cereb.Blood Flow Metab. 22 723 PMID: 12045671

Mori et al (2006) Arundic acid ameliorates cerebral amyloidosis and gliosis in Alzheimer transgenic mice. J.Pharmacol.Exp.Ther. 318 571 PMID: 16709678


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Keywords: ONO2506 S100B bbb blood brain barrier stroke neuroprotective Alzheimer's parkinson's disease astrocytes astrocytic arundic acid parkinsons alzheimers Arundic acid Neuronal Metabolism

Citations for ONO 2506

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New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

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  • Signal Transduction
  • Stem Cells

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