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Biological Activity for ONO 2506
ONO 2506 inhibits S-100β synthesis in activated cultured astrocytes. Prevents delayed infarct expansion 24 hours after permanent middle cerebral artery occlusion (pMCAO) in rats; also exhibits neuroprotective effects in mouse models of Parkinson's disease and Alzheimer's disease.
Technical Data for ONO 2506
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ONO 2506
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for ONO 2506
The following data is based on the product molecular weight 186.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||5.37 mL||26.84 mL||53.68 mL|
|5 mM||1.07 mL||5.37 mL||10.74 mL|
|10 mM||0.54 mL||2.68 mL||5.37 mL|
|50 mM||0.11 mL||0.54 mL||1.07 mL|
References for ONO 2506
References are publications that support the biological activity of the product.
Kato et al (2004) Arundic acid, an astrocyte-modulating agent, protects DArgic neurons against MPTP neurotoxicity in mice. Brain Res. 1030 66 PMID: 15567338
Tateishi et al (2002) Astrocytic activation and delayed infarct expansion after permanent focal ischemia in rats. Part II: suppression of astrocytic activation by a novel agent (R)-(-)-2-propyloctanoic acid (ONO-2506) leads to mitigation of delayed infarct expansion and early J.Cereb.Blood Flow Metab. 22 723 PMID: 12045671
Mori et al (2006) Arundic acid ameliorates cerebral amyloidosis and gliosis in Alzheimer transgenic mice. J.Pharmacol.Exp.Ther. 318 571 PMID: 16709678
If you know of a relevant reference for ONO 2506, please let us know.
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1 Citation for ONO 2506
Citations are publications that use Tocris products. Selected citations for ONO 2506 include:
Hao et al (2017) Arundic Acid Prevents Developmental Upregulation of S100B Expression and Inhibits Enteric Glial Development. Front Cell Neurosci 11 42 PMID: 28280459
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