ONO 1078

Discontinued Product

ONO 1078 (Cat. No. 3026) has been withdrawn from sale for commercial reasons.
Description: Selective CysLT1 antagonist; also TREK2 activator
Alternative Names: Pranlukast
Chemical Name: N-[4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4(4-phenylbutoxy)benzamide
Purity: ≥99% (HPLC)

Biological Activity for ONO 1078

ONO 1078 is a selective cysteinyl leukotriene receptor 1 (CysLT1) antagonist (IC50 values are ~ 4 - 7 and 3620 nM for CysLT1 and CysLT2 respectively). Inhibits contraction of airway smooth muscle, microvascular leakage into airways and eosinophil infiltration. Can decrease symptoms of bronchial asthma. Also TREK2 activator (pEC50 = 5.8); exhibits selectivity for TREK-2 over other K2P channels.

Technical Data for ONO 1078

M. Wt 481.5
Formula C27H23N5O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 103177-37-3
PubChem ID 4887
Smiles O=C2C1=CC=CC(NC(C4=CC=C(OCCCCC5=CC=CC=C5)C=C4)=O)=C1OC(C3=NN=NN3)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for ONO 1078

References are publications that support the biological activity of the product.

Lynch et al (1999) Characterization of the human leukotriene CysLT1 receptor. Nature 399 789 PMID: 10391245

Heise et al (2000) Characterization of the human cysteinyl leukotriene 2 receptor. J.Biol.Chem. 275 30531 PMID: 10851239

Suzuki et al (2003) Inhibition of human eosinophil activation by a cysteinyl leukotriene receptor antagonist (Pranlukast; ONO-1078). J.Asthma 40 395 PMID: 12870835

Wright et al (2019) Pranlukast is a novel small molecule activator of the two-pore domain potassium channel TREK2. Biochem.Biophys.Res.Commun. 520 35 PMID: 31564414

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Keywords: ONO 1078, ONO 1078 supplier, Selective, CysLT1, antagonists, Receptors, leukotrienes, eicosanoids, ONO1078, TREK-2, activators, activates, K2P10.1, Pranlukast, Leukotriene, and, Related, Two-P, Potassium, Channels, 3026, Tocris Bioscience

Citations for ONO 1078

Citations are publications that use Tocris products.

Currently there are no citations for ONO 1078.

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