ONO 1078

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Cat.No. 3026 - ONO 1078 | C27H23N5O4 | CAS No. 103177-37-3
Description: Selective CysLT1 antagonist
Alternative Names: Pranlukast
Chemical Name: N-[4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4(4-phenylbutoxy)benzamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective cysteinyl leukotriene receptor 1 (CysLT1) antagonist (IC50 values are ~ 4 - 7 and 3620 nM for CysLT1 and CysLT2 respectively). Inhibits contraction of airway smooth muscle, microvascular leakage into airways and eosinophil infiltration. Can decrease symptoms of bronchial asthma.

Technical Data

M. Wt 481.5
Formula C27H23N5O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 103177-37-3
PubChem ID 4887
InChI Key NBQKINXMPLXUET-UHFFFAOYSA-N
Smiles O=C2C1=CC=CC(NC(C4=CC=C(OCCCCC5=CC=CC=C5)C=C4)=O)=C1OC(C3=NN=NN3)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 24.07 50

Preparing Stock Solutions

The following data is based on the product molecular weight 481.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.08 mL 10.38 mL 20.77 mL
5 mM 0.42 mL 2.08 mL 4.15 mL
10 mM 0.21 mL 1.04 mL 2.08 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Lynch et al (1999) Characterization of the human leukotriene CysLT1 receptor. Nature 399 789 PMID: 10391245

Heise et al (2000) Characterization of the human cysteinyl leukotriene 2 receptor. J.Biol.Chem. 275 30531 PMID: 10851239

Suzuki et al (2003) Inhibition of human eosinophil activation by a cysteinyl leukotriene receptor antagonist (Pranlukast; ONO-1078). J.Asthma 40 395 PMID: 12870835


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Pathways for ONO 1078

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