Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewONO 1078
Description: Selective CysLT1 antagonist; also TREK2 activator
Alternative Names: Pranlukast
Chemical Name: N-[4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4(4-phenylbutoxy)benzamide
Purity: ≥99% (HPLC)
Biological Activity for ONO 1078
ONO 1078 is a selective cysteinyl leukotriene receptor 1 (CysLT1) antagonist (IC50 values are ~ 4 - 7 and 3620 nM for CysLT1 and CysLT2 respectively). Inhibits contraction of airway smooth muscle, microvascular leakage into airways and eosinophil infiltration. Can decrease symptoms of bronchial asthma. Also TREK2 activator (pEC50 = 5.8); exhibits selectivity for TREK-2 over other K2P channels.
Compound Libraries for ONO 1078
ONO 1078 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for ONO 1078
| M. Wt | 481.5 |
| Formula | C27H23N5O4 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 103177-37-3 |
| PubChem ID | 4887 |
| InChI Key | NBQKINXMPLXUET-UHFFFAOYSA-N |
| Smiles | O=C2C1=CC=CC(NC(C4=CC=C(OCCCCC5=CC=CC=C5)C=C4)=O)=C1OC(C3=NN=NN3)=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ONO 1078
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.07 | 50 |
Preparing Stock Solutions for ONO 1078
The following data is based on the product molecular weight 481.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.15 mL | 20.77 mL | 41.54 mL |
| 2.5 mM | 0.83 mL | 4.15 mL | 8.31 mL |
| 5 mM | 0.42 mL | 2.08 mL | 4.15 mL |
| 25 mM | 0.08 mL | 0.42 mL | 0.83 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for ONO 1078
References for ONO 1078
References are publications that support the biological activity of the product.
Lynch et al (1999) Characterization of the human leukotriene CysLT1 receptor. Nature 399 789 PMID: 10391245
Heise et al (2000) Characterization of the human cysteinyl leukotriene 2 receptor. J.Biol.Chem. 275 30531 PMID: 10851239
Suzuki et al (2003) Inhibition of human eosinophil activation by a cysteinyl leukotriene receptor antagonist (Pranlukast; ONO-1078). J.Asthma 40 395 PMID: 12870835
Wright et al (2019) Pranlukast is a novel small molecule activator of the two-pore domain potassium channel TREK2. Biochem.Biophys.Res.Commun. 520 35 PMID: 31564414
If you know of a relevant reference for ONO 1078, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: ONO 1078, ONO 1078 supplier, Selective, CysLT1, antagonists, Receptors, leukotrienes, eicosanoids, ONO1078, TREK-2, activators, activates, K2P10.1, Pranlukast, Leukotriene, and, Related, Two-P, Potassium, Channels, 3026, Tocris Bioscience
Citations for ONO 1078
Citations are publications that use Tocris products.
Currently there are no citations for ONO 1078. Do you know of a great paper that uses ONO 1078 from Tocris? Please let us know.
Reviews for ONO 1078
There are currently no reviews for this product. Be the first to review ONO 1078 and earn rewards!
Have you used ONO 1078?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cardiovascular Research Product Guide
A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:
- Hypertension
- Thrombosis and Hemostasis
- Atherosclerosis
- Myocardial Infarction
- Ischemia/Reperfusion Injury
- Arrhythmias
- Heart Failure
GPCR Product Listing
A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:
- Rhodopsin-like Receptors
- Glutamate Receptors
- Frizzled Receptors
- GPCR Signaling
Immunology Product Listing
A collection of over 190 products for immunology research, the guide includes research tools for the study of:
- Chemokine and Cytokine Signaling
- Chemotaxis
- Complement System
- Immune Cell Signaling
- Inflammation
Cardiovascular Poster
Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.