Discontinued Product

OMDM-2 (Cat. No. 1797) has been withdrawn from sale for commercial reasons.
Description: Potent inhibitor of anandamide uptake
Chemical Name: (9Z)-N-[1-((R)-4-Hydroxbenzyl)-2-hydroxyethyl]-9-octadecenamide
Purity: ≥99% (HPLC)
Citations (1)
Literature (2)

Biological Activity for OMDM-2

OMDM-2 is a metabolically stable inhibitor of anandamide cellular uptake (Ki = 3 μM). Displays relatively low affinity for CB1 and CB2 receptors (Ki values are 5.1 and > 10 μM) and for vanilloid VR1 receptors (EC50 = 10 μM). FABP inhibitor. Has minimal activity against FAAH (Ki > 50 μM). Active in vivo.

Technical Data for OMDM-2

M. Wt 431.66
Formula C27H45NO3
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 616884-63-0
PubChem ID 9928181

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for OMDM-2

References are publications that support the biological activity of the product.

Ortar et al (2003) Novel selective and metabolically stable inhibitors of anandamide cellular uptake. Biochem.Pharmacol. 35 1473 PMID: 12732359

de Lago et al (2004) In vivo pharmacological actions of two novel inhibitors of anandamide cellular uptake. Eur.J.Pharmacol. 484 249 PMID: 14744610

Deutsch (2016) A personal retrospective: Elevating Anandamide (AEA) by targeting fatty acid amide hydrolase (FAAH) and the fatty acid binding proteins (FABPs). Front.Pharmacol. 7 370 PMID: 27790143

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Keywords: OMDM-2, OMDM-2 supplier, Potent, inhibitors, inhibits, anandamide, reuptake, AMT, Transporters, cannabinoids, Monoamine, Neurotransmitter, FABPs, FABP, fatty, acid, binding, proteins, Cannabinoid, Fatty, Acid, Binding, Proteins, 1797, Tocris Bioscience

1 Citation for OMDM-2

Citations are publications that use Tocris products. Selected citations for OMDM-2 include:

Bátkai et al (2004) Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension. FASEB J 110 1996 PMID: 15451779

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cannabinoid Receptor Ligands Scientific Review

Cannabinoid Receptor Ligands Scientific Review

Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.

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