OMDM-2

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Cat.No. 1797 - OMDM-2 | C27H45NO3 | CAS No. 616884-63-0
Description: Potent inhibitor of anandamide uptake
Chemical Name: (9Z)-N-[1-((R)-4-Hydroxbenzyl)-2-hydroxyethyl]-9-octadecenamide
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Metabolically stable inhibitor of anandamide cellular uptake (Ki = 3 μM). Displays relatively low affinity for CB1 and CB2 receptors (Ki values are 5.1 and > 10 μM) and for vanilloid VR1 receptors (EC50 = 10 μM). Has minimal activity against FAAH (Ki > 50 μM). Active in vivo.

Technical Data

M. Wt 431.66
Formula C27H45NO3
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 616884-63-0
PubChem ID 9928181
InChI Key ITXVOUSORXSTQH-UHFFFAOYSA-N
Smiles CCCCCCCC\C=C/CCCCCCCC(=O)N[C@@H](CO)CC1=CC=C(O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.32 10
ethanol 4.32 10

Preparing Stock Solutions

The following data is based on the product molecular weight 431.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.32 mL 11.58 mL 23.17 mL
5 mM 0.46 mL 2.32 mL 4.63 mL
10 mM 0.23 mL 1.16 mL 2.32 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Ortar et al (2003) Novel selective and metabolically stable inhibitors of anandamide cellular uptake. Biochem.Pharmacol. 35 1473 PMID: 12732359

de Lago et al (2004) In vivo pharmacological actions of two novel inhibitors of anandamide cellular uptake. Eur.J.Pharmacol. 484 249 PMID: 14744610


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Keywords: Potent inhibitors inhibits anandamide reuptake AMT Transporters cannabinoids Monoamine Neurotransmitter Cannabinoid Transporters

1 Citation for OMDM-2

Citations are publications that use Tocris products. Selected citations for OMDM-2 include:

Bátkai et al (2004) Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension. FASEB J 110 1996 PMID: 15451779


Do you know of a great paper that uses OMDM-2 from Tocris? If so please let us know.

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Literature in this Area

Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
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Cannabinoid Receptor Ligands

Cannabinoid Receptor Ligands Scientific Review

Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.

Pathways for OMDM-2

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