Oltipraz

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Cat.No. 5294 - Oltipraz | C8H6N2S3 | CAS No. 64224-21-1
Description: Nrf2 activator
Chemical Name: 4-Methyl-5-(2-pyrazinyl)-3H-1,2-dithiole-3-thione
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Nrf2 activator; activates Nrf, which binds to antioxidant response elements (AREs) and induces Phase-I and -II drug-metabolizing enzymes including CYP2B and NQO1. Also increases mRNA levels of multiple hepatic xenobiotic transporters. Elevates expression of genes encoding anti-oxidant and multidrug resistance-associated proteins. Displays chemopreventive activity.

Technical Data

M. Wt 226.34
Formula C8H6N2S3
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 64224-21-1
PubChem ID 47318
InChI Key CKNAQFVBEHDJQV-UHFFFAOYSA-N
Smiles CC1=C(SSC1=S)C2=CN=CC=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 11.32 50

Preparing Stock Solutions

The following data is based on the product molecular weight 226.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.42 mL 22.09 mL 44.18 mL
5 mM 0.88 mL 4.42 mL 8.84 mL
10 mM 0.44 mL 2.21 mL 4.42 mL
50 mM 0.09 mL 0.44 mL 0.88 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Merrell et al (2008) Induction of drug metabolism enzymes and transporters by oltipraz in rats. J.Biochem.Mol.Toxicol. 22 128 PMID: 18418891

Manandhar et al (2007) Induction of Nrf2-regulated genes by 3H-1, 2-dithiole-3-thione through the ERK signaling pathway in murine keratinocytes. Eur J Pharmacol. 577 17 PMID: 17854798

Maher et al (2007) Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway. Hepatology 46 1597 PMID: 17668877


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Keywords: Nrf2 activators nuclear factor-E2-related factor-2 phase-I -II drug-metabolizing enzymes transporters chemopreventive Nrf2

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Neurodegeneration

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