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Nrf2 activator; activates Nrf, which binds to antioxidant response elements (AREs) and induces Phase-I and -II drug-metabolizing enzymes including CYP2B and NQO1. Also increases mRNA levels of multiple hepatic xenobiotic transporters. Elevates expression of genes encoding anti-oxidant and multidrug resistance-associated proteins. Displays chemopreventive activity.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 226.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||8.84 mL||44.18 mL||88.36 mL|
|2.5 mM||1.77 mL||8.84 mL||17.67 mL|
|5 mM||0.88 mL||4.42 mL||8.84 mL|
|25 mM||0.18 mL||0.88 mL||1.77 mL|
References are publications that support the biological activity of the product.
Merrell et al (2008) Induction of drug metabolism enzymes and transporters by oltipraz in rats. J.Biochem.Mol.Toxicol. 22 128 PMID: 18418891
Manandhar et al (2007) Induction of Nrf2-regulated genes by 3H-1, 2-dithiole-3-thione through the ERK signaling pathway in murine keratinocytes. Eur J Pharmacol. 577 17 PMID: 17854798
Maher et al (2007) Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway. Hepatology 46 1597 PMID: 17668877
If you know of a relevant reference for Oltipraz, please let us know.
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Keywords: Oltipraz, Oltipraz supplier, Nrf2, activators, nuclear, factor-E2-related, factor-2, phase-I, -II, drug-metabolizing, enzymes, transporters, chemopreventive, 5294, Tocris Bioscience
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