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Biological Activity for Olopatadine hydrochloride
Olopatadine hydrochloride is a histamine H1 receptor antagonist (Ki = 31.6 nM). Inhibits the release of histamine, prostaglandin D2 and tryptase in a concentration-dependent manner. Mast cell stabilizer; inhibits mast cell mediator release. Also suppresses inflammation by inhibition of cytokine production.
Compound Libraries for Olopatadine hydrochloride
Technical Data for Olopatadine hydrochloride
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Olopatadine hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Olopatadine hydrochloride
The following data is based on the product molecular weight 373.87. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.67 mL||13.37 mL||26.75 mL|
|5 mM||0.53 mL||2.67 mL||5.35 mL|
|10 mM||0.27 mL||1.34 mL||2.67 mL|
|50 mM||0.05 mL||0.27 mL||0.53 mL|
Product Datasheets for Olopatadine hydrochloride
References for Olopatadine hydrochloride
References are publications that support the biological activity of the product.
Tamura et al (2007) Olopatidine ameliorates rat experimental cutaneous inflammation by improving skin barrier function. Pharmacology 81 118 PMID: 17962722
Sharif et al (1996) Characterization of the ocular antiallergic and antihistaminic effects of olopatidine (AL-4943A), a novel drug for treating ocular allergic diseases. J.Pharm.Exp.Ther. 278 1252
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Keywords: Olopatadine hydrochloride, Olopatadine hydrochloride supplier, histamine, H1, antagonists, antihistamines, mast, cell, stabilizers, ocular, antiallergic, Histamine, Receptors, 4241, Tocris Bioscience
Citations for Olopatadine hydrochloride
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Literature in this Area
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