Olopatadine hydrochloride

Pricing Availability   Qty
Description: H1 antagonist; ocular antiallergic agent
Chemical Name: (Z)-11-[3-(Dimethylamino)propylidene]-6,11-dihydro-dibenz[b,e]oxepin-2-acetic acid hydrochloride
Purity: ≥99% (HPLC)
Literature (1)

Biological Activity for Olopatadine hydrochloride

Olopatadine hydrochloride is a histamine H1 receptor antagonist (Ki = 31.6 nM). Inhibits the release of histamine, prostaglandin D2 and tryptase in a concentration-dependent manner. Mast cell stabilizer; inhibits mast cell mediator release. Also suppresses inflammation by inhibition of cytokine production.

Compound Libraries for Olopatadine hydrochloride

Olopatadine hydrochloride is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Olopatadine hydrochloride

M. Wt 373.87
Formula C21H23NO3.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 140462-76-6
PubChem ID 5282402
Smiles O=C(CC(C=C3)=CC/1=C3OCC(C=CC=C2)=C2C1=C\CCN(C)C)O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Olopatadine hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 28.04 75
DMSO 37.39 100

Preparing Stock Solutions for Olopatadine hydrochloride

The following data is based on the product molecular weight 373.87. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.67 mL 13.37 mL 26.75 mL
5 mM 0.53 mL 2.67 mL 5.35 mL
10 mM 0.27 mL 1.34 mL 2.67 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

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Product Datasheets for Olopatadine hydrochloride

References for Olopatadine hydrochloride

References are publications that support the biological activity of the product.

Tamura et al (2007) Olopatidine ameliorates rat experimental cutaneous inflammation by improving skin barrier function. Pharmacology 81 118 PMID: 17962722

Sharif et al (1996) Characterization of the ocular antiallergic and antihistaminic effects of olopatidine (AL-4943A), a novel drug for treating ocular allergic diseases. J.Pharmacol.Exp.Ther. 278 1252 PMID: 8819509

If you know of a relevant reference for Olopatadine hydrochloride, please let us know.

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Keywords: Olopatadine hydrochloride, Olopatadine hydrochloride supplier, histamine, H1, antagonists, antihistamines, mast, cell, stabilizers, ocular, antiallergic, Histamine, Receptors, 4241, Tocris Bioscience

Citations for Olopatadine hydrochloride

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Literature in this Area

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Histamine Receptors Scientific Review

Histamine Receptors Scientific Review

Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.