Olopatadine hydrochloride

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Cat.No. 4241 - Olopatadine hydrochloride | C21H23NO3.HCl | CAS No. 140462-76-6
Description: H1 antagonist; ocular antiallergic agent
Chemical Name: (Z)-11-[3-(Dimethylamino)propylidene]-6,11-dihydro-dibenz[b,e]oxepin-2-acetic acid hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Histamine H1 receptor antagonist (Ki = 31.6 nM). Inhibits the release of histamine, prostaglandin D2 and tryptase in a concentration-dependent manner. Mast cell stabilizer; inhibits mast cell mediator release. Also suppresses inflammation by inhibition of cytokine production.

Compound Libraries

Olopatadine hydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 373.87
Formula C21H23NO3.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 140462-76-6
PubChem ID 5282402
InChI Key HVRLZEKDTUEKQH-NOILCQHBSA-N
Smiles O=C(CC(C=C3)=CC/1=C3OCC(C=CC=C2)=C2C1=C\CCN(C)C)O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.39 100
water 28.04 75

Preparing Stock Solutions

The following data is based on the product molecular weight 373.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.67 mL 13.37 mL 26.75 mL
5 mM 0.53 mL 2.67 mL 5.35 mL
10 mM 0.27 mL 1.34 mL 2.67 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Tamura et al (2007) Olopatidine ameliorates rat experimental cutaneous inflammation by improving skin barrier function. Pharmacology 81 118 PMID: 17962722

Sharif et al (1996) Characterization of the ocular antiallergic and antihistaminic effects of olopatidine (AL-4943A), a novel drug for treating ocular allergic diseases. J.Pharm.Exp.Ther. 278 1252 PMID:


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Keywords: Olopatadine hydrochloride, supplier, histamine, H1, antagonists, antihistamines, mast, cell, stabilizers, ocular, antiallergic, Histamine, H1, Receptors, Histamine, H1, Receptors, Tocris Bioscience

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