Olomoucine

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Cat.No. 1284 - Olomoucine | C15H18N6O | CAS No. 101622-51-9
Description: Cyclin-dependent kinase inhibitor
Chemical Name: 6-(Benzylamino)-2-(2-hydroxyethylamino)-9-methylpurine
Datasheet
Citations (1)
Literature

Biological Activity

Cyclin-dependent kinase inhibitor that competes for the ATP binding site of the kinase. Selectively inhibits cdc2/cyclin B (IC50 = 7 μM), cdk2/cyclin A (IC50 = 7 μM), cdk2/cyclin E (IC50 = 7 μM), cdk/p35 kinase (IC50 = 3 μM)  and ERK1/MAP kinase (IC50 = 25 μM). Arrests human fibroblasts in the G1 phase.

Technical Data

M. Wt 298.35
Formula C15H18N6O
Storage Desiccate at -20°C
CAS Number 101622-51-9
PubChem ID 4592
InChI Key GTVPOLSIJWJJNY-UHFFFAOYSA-N
Smiles CN1C=NC2=C(NCC3=CC=CC=C3)N=C(NCCO)N=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 50 mM in ethanol

Preparing Stock Solutions

The following data is based on the product molecular weight 298.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.35 mL 16.76 mL 33.52 mL
5 mM 0.67 mL 3.35 mL 6.7 mL
10 mM 0.34 mL 1.68 mL 3.35 mL
50 mM 0.07 mL 0.34 mL 0.67 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Abraham et al (1995) Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases. Biol.Cell 83 105 PMID: 7549905

Alessi et al (1998) The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human fibroblasts in G1 phase by specific inhibition of CDK2 kinase activity. Exp.Cell.Res. 245 8 PMID: 9828096

Vesely et al (1994) Inhibition of cyclin-dependent kinases by purine analogues. Eur.J.Biochem. 224 771 PMID: 7925396


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Keywords: Olomoucine, supplier, Cyclin-dependent, protein, kinases, inhibitors, inhibits, Cdks, Cyclin-dependent, Kinase, Cyclin-dependent, Kinase, Tocris Bioscience

1 Citation for Olomoucine

Citations are publications that use Tocris products. Selected citations for Olomoucine include:

Cannon et al (2009) Association of luteinizing hormone receptor gene expression with cell cycle progression in granulosa cells. Am J Physiol Endocrinol Metab 296 E1392 PMID: 19293332


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