Olomoucine

Pricing Availability   Qty
Cat.No. 1284 - Olomoucine | C15H18N6O | CAS No. 101622-51-9
Description: Cdk inhibitor
Chemical Name: 6-(Benzylamino)-2-(2-hydroxyethylamino)-9-methylpurine
Datasheet
Citations (1)
Reviews
Literature (4)

Biological Activity

ATP-competitive cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 0.6 and 0.94 - 8 μM for cdk7 and cdk2 respectively, and >1 μM for cdk1 and cdk9. Induces cell cycle arrest at G1 in human fibroblasts.

Technical Data

M. Wt 298.35
Formula C15H18N6O
Storage Desiccate at -20°C
CAS Number 101622-51-9
PubChem ID 4592
InChI Key GTVPOLSIJWJJNY-UHFFFAOYSA-N
Smiles CN1C=NC2=C(NCC3=CC=CC=C3)N=C(NCCO)N=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 50

Preparing Stock Solutions

The following data is based on the product molecular weight 298.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 6.7 mL 33.52 mL 67.04 mL
2.5 mM 1.34 mL 6.7 mL 13.41 mL
5 mM 0.67 mL 3.35 mL 6.7 mL
25 mM 0.13 mL 0.67 mL 1.34 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Abraham et al (1995) Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases. Biol.Cell 83 105 PMID: 7549905

Alessi et al (1998) The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human fibroblasts in G1 phase by specific inhibition of CDK2 kinase activity. Exp.Cell.Res. 245 8 PMID: 9828096

Vesely et al (1994) Inhibition of cyclin-dependent kinases by purine analogues. Eur.J.Biochem. 224 771 PMID: 7925396

Jorda et al (2018) How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 61 9105 PMID: 30234987


If you know of a relevant reference for Olomoucine, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Cyclin-Dependent Protein Kinase Inhibitors

Keywords: Olomoucine, Olomoucine supplier, Cyclin-dependent, protein, kinases, inhibitors, inhibits, Cdks, Kinase, 1284, Tocris Bioscience

1 Citation for Olomoucine

Citations are publications that use Tocris products. Selected citations for Olomoucine include:

Cannon et al (2009) Association of luteinizing hormone receptor gene expression with cell cycle progression in granulosa cells. Am J Physiol Endocrinol Metab 296 E1392 PMID: 19293332


Do you know of a great paper that uses Olomoucine from Tocris? Please let us know.

Reviews for Olomoucine

There are currently no reviews for this product. Be the first to review Olomoucine and earn rewards!

Have you used Olomoucine?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
Cell Cycle & DNA Damage Repair

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.