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Submit ReviewOG-L002
Description: Potent LSD1 inhibitor
Chemical Name: 4'-((1R,2S)-2-aminocyclopropyl)biphenyl-3-ol
Purity: ≥98% (HPLC)
Biological Activity for OG-L002
OG-L002 is a potent LSD1 inhibitor (IC50 = 20 nM). Exhibits some selectivity for LSD1 over MAO-B and MAO-A (IC50 values are 0.72 and 1.38 μM, respectively). Inhibits herpes simplex virus (HSV) immediate early gene expression and viral yield in vitro. Suppresses HSV primary infection in vivo.
Technical Data for OG-L002
| M. Wt | 225.29 |
| Formula | C15H15NO |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1357302-64-7 |
| PubChem ID | 56639570 |
| InChI Key | DSOJSZXQRJGBCW-CABCVRRESA-N |
| Smiles | N[C@H]1C[C@@H]1C2=CC=C(C3=CC(O)=CC=C3)C=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for OG-L002
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 22.53 | 100 | |
| ethanol | 22.53 | 100 | |
| 1eq. HCl | 4.51 | 20 |
Preparing Stock Solutions for OG-L002
The following data is based on the product molecular weight 225.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.44 mL | 22.19 mL | 44.39 mL |
| 5 mM | 0.89 mL | 4.44 mL | 8.88 mL |
| 10 mM | 0.44 mL | 2.22 mL | 4.44 mL |
| 50 mM | 0.09 mL | 0.44 mL | 0.89 mL |
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Product Datasheets for OG-L002
References for OG-L002
References are publications that support the biological activity of the product.
Liang et al (2013) A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency. MBio. 4 e00558 PMID: 23386436
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Keywords: OG-L002, OG-L002 supplier, Antiviral, LSD1, inhibitors, inhibits, lysine, demethylase, 1, inhibitor, herpes, simplex, virus, HSV, potent, Histone, Demethylases, Herpes, Simplex, Viruses, 6244, Tocris Bioscience
1 Citation for OG-L002
Citations are publications that use Tocris products. Selected citations for OG-L002 include:
Chris et al (2020) Neuronal hyperexcitability is a DLK-dependent trigger of herpes simplex virus reactivation that can be induced by IL-1. Elife 9 PMID: 33350386
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Literature in this Area
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