OG-L002

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Cat.No. 6244 - OG-L002 | C15H15NO | CAS No. 1357302-64-7
Description: Potent LSD1 inhibitor
Chemical Name: 4'-((1R,2S)-2-aminocyclopropyl)biphenyl-3-ol
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent LSD1 inhibitor (IC50 = 20 nM). Exhibits some selectivity for LSD1 over MAO-B and MAO-A (IC50 values are 0.72 and 1.38 μM, respectively). Inhibits herpes simplex virus (HSV) immediate early gene expression and viral yield in vitro. Suppresses HSV primary infection in vivo.

Technical Data

M. Wt 225.29
Formula C15H15NO
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1357302-64-7
PubChem ID 56639570
InChI Key DSOJSZXQRJGBCW-CABCVRRESA-N
Smiles N[C@H]1C[C@@H]1C2=CC=C(C3=CC(O)=CC=C3)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.53 100
ethanol 22.53 100
1eq. HCl 4.51 20

Preparing Stock Solutions

The following data is based on the product molecular weight 225.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.44 mL 22.19 mL 44.39 mL
5 mM 0.89 mL 4.44 mL 8.88 mL
10 mM 0.44 mL 2.22 mL 4.44 mL
50 mM 0.09 mL 0.44 mL 0.89 mL

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References

References are publications that support the biological activity of the product.

Liang et al (2013) A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency. MBio. 4 e00558 PMID: 23386436


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
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  • Invasion and Metastasis
Epigenetics

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

Epigenetics

Epigenetics Research Bulletin

Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:

  • Bromodomains
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  • Histone Deacetylases
  • Histone Demethylases
  • Histone Methyltransferases