Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: Potent LSD1 inhibitor
Chemical Name: 4'-((1R,2S)-2-aminocyclopropyl)biphenyl-3-ol
Purity: ≥98% (HPLC)
Citations (1)
Literature (1)

Biological Activity for OG-L002

OG-L002 is a potent LSD1 inhibitor (IC50 = 20 nM). Exhibits some selectivity for LSD1 over MAO-B and MAO-A (IC50 values are 0.72 and 1.38 μM, respectively). Inhibits herpes simplex virus (HSV) immediate early gene expression and viral yield in vitro. Suppresses HSV primary infection in vivo.

Technical Data for OG-L002

M. Wt 225.29
Formula C15H15NO
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1357302-64-7
PubChem ID 56639570
Smiles N[C@H]1C[C@@H]1C2=CC=C(C3=CC(O)=CC=C3)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for OG-L002

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 22.53 100
ethanol 22.53 100
1eq. HCl 4.51 20

Preparing Stock Solutions for OG-L002

The following data is based on the product molecular weight 225.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.44 mL 22.19 mL 44.39 mL
5 mM 0.89 mL 4.44 mL 8.88 mL
10 mM 0.44 mL 2.22 mL 4.44 mL
50 mM 0.09 mL 0.44 mL 0.89 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for OG-L002

References are publications that support the biological activity of the product.

Liang et al (2013) A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency. MBio. 4 e00558 PMID: 23386436

If you know of a relevant reference for OG-L002, please let us know.

View Related Products by Product Action

View all Histone Demethylase Inhibitors

Keywords: OG-L002, OG-L002 supplier, Antiviral, LSD1, inhibitors, inhibits, lysine, demethylase, 1, inhibitor, herpes, simplex, virus, HSV, potent, Histone, Demethylases, Herpes, Simplex, Viruses, 6244, Tocris Bioscience

1 Citation for OG-L002

Citations are publications that use Tocris products. Selected citations for OG-L002 include:

Chris et al (2020) Neuronal hyperexcitability is a DLK-dependent trigger of herpes simplex virus reactivation that can be induced by IL-1. Elife 9 PMID: 33350386

Do you know of a great paper that uses OG-L002 from Tocris? Please let us know.

Reviews for OG-L002

There are currently no reviews for this product. Be the first to review OG-L002 and earn rewards!

Have you used OG-L002?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.