OG-L002

Pricing Availability   Qty
Description: Potent LSD1 inhibitor
Chemical Name: 4'-((1R,2S)-2-aminocyclopropyl)biphenyl-3-ol
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (2)

Biological Activity for OG-L002

OG-L002 is a potent LSD1 inhibitor (IC50 = 20 nM). Exhibits some selectivity for LSD1 over MAO-B and MAO-A (IC50 values are 0.72 and 1.38 μM, respectively). Inhibits herpes simplex virus (HSV) immediate early gene expression and viral yield in vitro. Suppresses HSV primary infection in vivo.

Technical Data for OG-L002

M. Wt 225.29
Formula C15H15NO
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1357302-64-7
PubChem ID 56639570
InChI Key DSOJSZXQRJGBCW-CABCVRRESA-N
Smiles N[C@H]1C[C@@H]1C2=CC=C(C3=CC(O)=CC=C3)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for OG-L002

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.53 100
ethanol 22.53 100
1eq. HCl 4.51 20

Preparing Stock Solutions for OG-L002

The following data is based on the product molecular weight 225.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.44 mL 22.19 mL 44.39 mL
5 mM 0.89 mL 4.44 mL 8.88 mL
10 mM 0.44 mL 2.22 mL 4.44 mL
50 mM 0.09 mL 0.44 mL 0.89 mL

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References for OG-L002

References are publications that support the biological activity of the product.

Liang et al (2013) A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency. MBio. 4 e00558 PMID: 23386436


If you know of a relevant reference for OG-L002, please let us know.

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Keywords: OG-L002, OG-L002 supplier, Antiviral, LSD1, inhibitors, inhibits, lysine, demethylase, 1, inhibitor, herpes, simplex, virus, HSV, potent, Histone, Demethylases, Herpes, Simplex, Viruses, 6244, Tocris Bioscience

1 Citation for OG-L002

Citations are publications that use Tocris products. Selected citations for OG-L002 include:

Chris et al (2020) Neuronal hyperexcitability is a DLK-dependent trigger of herpes simplex virus reactivation that can be induced by IL-1. Elife 9 PMID: 33350386


Do you know of a great paper that uses OG-L002 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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Epigenetics Scientific Review

Epigenetics Scientific Review

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