Ochratoxin A

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Cat.No. 1291 - Ochratoxin A | C20H18ClNO6 | CAS No. 303-47-9
Description: Stimulates SERCA-ATP-dependent Ca2+ pump activity
Chemical Name: N-[[(3R)-5-Chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-L-phenylalanine
Purity: ≥99% (HPLC)
Datasheet
Citations

Biological Activity

Mycotoxin that increases activity of the endoplasmic reticulum ATP-dependent calcium pump. Induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations. Stimulates lipid peroxidation.

Technical Data

M. Wt 403.82
Formula C20H18ClNO6
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 303-47-9
PubChem ID 442530
InChI Key RWQKHEORZBHNRI-BMIGLBTASA-N
Smiles OC1=C(C(N[C@H]([C@@](O)=O)CC3=CC=CC=C3)=O)C=C(Cl)C2=C1C(O[C@H](C)C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.38 100
ethanol 20.19 50

Preparing Stock Solutions

The following data is based on the product molecular weight 403.82. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.48 mL 12.38 mL 24.76 mL
5 mM 0.5 mL 2.48 mL 4.95 mL
10 mM 0.25 mL 1.24 mL 2.48 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Chong and Rahimtula (1992) Alterations in ATP-dependent calcium uptake by rat renal cortex microsomes following ochratoxin A administration in vitro. Biochem.Pharmacol. 44 1401 PMID: 1417961

Dirheimer and Creppy (1991) Mechanism of action of ochratoxin A. IARC Sci.Publ. 115 171 PMID: 1820332

Gekle et al (2000) Ochratoxin A induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations. J.Pharmacol.Exp.Ther. 293 837 PMID: 10869383

Omar et al (1991) Role of cytochrome-P-450 in ochratoxin-A stimulated lipid-peroxidation. J.Biochem.Toxicol. 6 203 PMID: 1770504

Merck Index 12 6836 PMID:


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