Ochratoxin A

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Cat.No. 1291 - Ochratoxin A | C20H18ClNO6 | CAS No. 303-47-9
Description: Stimulates SERCA-ATP-dependent Ca2+ pump activity
Chemical Name: N-[[(3R)-5-Chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-L-phenylalanine
Purity: ≥99% (HPLC)

Biological Activity for Ochratoxin A

Ochratoxin A is a mycotoxin that increases activity of the endoplasmic reticulum ATP-dependent calcium pump. Induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations. Stimulates lipid peroxidation.

Technical Data for Ochratoxin A

M. Wt 403.82
Formula C20H18ClNO6
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 303-47-9
PubChem ID 442530
Smiles OC1=C(C(N[C@H]([C@@](O)=O)CC3=CC=CC=C3)=O)C=C(Cl)C2=C1C(O[C@H](C)C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ochratoxin A

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 20.19 50
DMSO 40.38 100

Preparing Stock Solutions for Ochratoxin A

The following data is based on the product molecular weight 403.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.48 mL 12.38 mL 24.76 mL
5 mM 0.5 mL 2.48 mL 4.95 mL
10 mM 0.25 mL 1.24 mL 2.48 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets for Ochratoxin A

Certificate of Analysis / Product Datasheet
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References for Ochratoxin A

References are publications that support the biological activity of the product.

Chong and Rahimtula (1992) Alterations in ATP-dependent calcium uptake by rat renal cortex microsomes following ochratoxin A administration in vitro. Biochem.Pharmacol. 44 1401 PMID: 1417961

Dirheimer and Creppy (1991) Mechanism of action of ochratoxin A. IARC Sci.Publ. 115 171 PMID: 1820332

Gekle et al (2000) Ochratoxin A induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations. J.Pharmacol.Exp.Ther. 293 837 PMID: 10869383

Omar et al (1991) Role of cytochrome-P-450 in ochratoxin-A stimulated lipid-peroxidation. J.Biochem.Toxicol. 6 203 PMID: 1770504

Merck Index 12 6836

If you know of a relevant reference for Ochratoxin A, please let us know.

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⚠ WARNING: This product can expose you to chemicals including Ochratoxin A, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov

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