OB 24 hydrochloride

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Description: Potent and selective heme oxygenase 1 (HO-1) inhibitor
Chemical Name: 1-[[2-[2-(4-Bromophenyl)ethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazole hydrochloride
Purity: ≥98% (HPLC)
Citations (2)

Biological Activity for OB 24 hydrochloride

OB 24 hydrochloride is a potent and selective heme oxygenase 1 (HO-1) inhibitor (IC50 values are 1.9 and >100 μM for HO-1 and HO-2 respectively), reduces protein carbonylation and reactive oxygen species formation in advanced prostate cancer cells (PCA). Inhibits cell proliferation in vitro and PCA tumor growth and lymph node/lung metastases in vivo. Synergizes with Taxol (Cat. No. 1097).

Compound Libraries for OB 24 hydrochloride

OB 24 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for OB 24 hydrochloride

M. Wt 373.67
Formula C15H17BrN2O2.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 939825-12-4
PubChem ID 45265865
Smiles BrC1=CC=C(C=C1)CCC2(OCCO2)CN3C=CN=C3.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for OB 24 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 37.4 100
DMSO 37.37 100

Preparing Stock Solutions for OB 24 hydrochloride

The following data is based on the product molecular weight 373.67. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.68 mL 13.38 mL 26.76 mL
5 mM 0.54 mL 2.68 mL 5.35 mL
10 mM 0.27 mL 1.34 mL 2.68 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Product Datasheets for OB 24 hydrochloride

Certificate of Analysis / Product Datasheet
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References for OB 24 hydrochloride

References are publications that support the biological activity of the product.

Alaoui-Jamali et al (2009) A novel experimental heme oxygenase-1-targeted therapy for hormone-refractory prostate cancer. Cancer Res. 69 8017 PMID: 19808972

If you know of a relevant reference for OB 24 hydrochloride, please let us know.

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Keywords: OB 24 hydrochloride, OB 24 hydrochloride supplier, OB24, HCl, selective, heme, oxygenase, 1, inhibitors, inhibits, Taxol, potent, HO1, HO_1, Heme, Oxygenase, 6119, Tocris Bioscience

2 Citations for OB 24 hydrochloride

Citations are publications that use Tocris products. Selected citations for OB 24 hydrochloride include:

Carolyn J et al (2021) Oxidized Lipoproteins Promote Resistance to Cancer Immunotherapy Independent of Patient Obesity. Cancer Immunol Res 9 214-226 PMID: 33303575

Thomas P et al (2021) Fructose Promotes Cytoprotection in Melanoma Tumors and Resistance to Immunotherapy. Cancer Immunol Res 9 227-238 PMID: 33023966

Do you know of a great paper that uses OB 24 hydrochloride from Tocris? Please let us know.

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