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Inhibitor of anandamide uptake (IC50 = 17.3 μM) with little or no activity at CB1, CB2, TRPV1 and FAAH. Intravenous administration inhibits limb spasticity in mice with chronic relapsing experimental allergic encephalomyelitis (CREAE).
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|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml)|
References are publications that support the biological activity of the product.
Di Marzo et al (2002) A structure/activity relationship study on arvanil, an endocannabinoid and vanilloid hybrid. J.Pharmacol.Exp.Ther. 300 984 PMID: 11861807
Ligresti et al (2006) New potent and selective inhibitors of anandamide reuptake with antispastic activity in a mouse model of multiple sclerosis. Br.J.Pharmacol. 147 83 PMID: 16284631
Griffin et al (2001) Activity of a novel anandamide analog suggests a non-CB1, non-VR1 site of action. 2001 Symposium on the Cannabinoids, International
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Keywords: O-2093, O-2093 supplier, inhibitors, inhibits, anandamide, reuptake, AMT, Transporters, Cannabinoids, Monoamine, Neurotransmitter, Cannabinoid, 1446, Tocris Bioscience
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