O-2093

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Cat.No. 1446 - O-2093 | C34H43Cl2NO3 | CAS No. 439080-01-0
Description: Inhibitor of anandamide uptake
Chemical Name: N-(bis-3-chloro-4-hydroxybenzyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
Datasheet
Citations
Reviews
Literature

Biological Activity

Inhibitor of anandamide uptake (IC50 = 17.3 μM) with little or no activity at CB1, CB2, TRPV1 and FAAH. Intravenous administration inhibits limb spasticity in mice with chronic relapsing experimental allergic encephalomyelitis (CREAE).

Licensing Information

Sold under license from VCU-IPF

Technical Data

M. Wt 584.62
Formula C34H43Cl2NO3
Storage Desiccate at -20°C
CAS Number 439080-01-0
PubChem ID 9894629
InChI Key XRJQDZXKLCOTGV-DOFZRALJSA-N
Smiles O=C(N(CC2=CC(Cl)=C(O)C=C2)CC1=CC(Cl)=C(O)C=C1)CCC\C=C/C\C=C/C/C=C\C/C=C\CCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml)

References

References are publications that support the biological activity of the product.

Di Marzo et al (2002) A structure/activity relationship study on arvanil, an endocannabinoid and vanilloid hybrid. J.Pharmacol.Exp.Ther. 300 984 PMID: 11861807

Ligresti et al (2006) New potent and selective inhibitors of anandamide reuptake with antispastic activity in a mouse model of multiple sclerosis. Br.J.Pharmacol. 147 83 PMID: 16284631

Griffin et al (2001) Activity of a novel anandamide analog suggests a non-CB1, non-VR1 site of action. 2001 Symposium on the Cannabinoids, International


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Citations for O-2093

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