O-2093

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Cat.No. 1446 - O-2093 | C34H43Cl2NO3 | CAS No. 439080-01-0
Description: Inhibitor of anandamide uptake
Chemical Name: N-(bis-3-chloro-4-hydroxybenzyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
Datasheet
Citations
Literature

Biological Activity

Inhibitor of anandamide uptake (IC50 = 17.3 μM) with little or no activity at CB1, CB2, TRPV1 and FAAH. Intravenous administration inhibits limb spasticity in mice with chronic relapsing experimental allergic encephalomyelitis (CREAE).

Licensing Information

Sold under license from VCU-IPF

Technical Data

M. Wt 584.62
Formula C34H43Cl2NO3
Storage Desiccate at -20°C
CAS Number 439080-01-0
PubChem ID 9894629
InChI Key XRJQDZXKLCOTGV-DOFZRALJSA-N
Smiles O=C(N(CC2=CC(Cl)=C(O)C=C2)CC1=CC(Cl)=C(O)C=C1)CCC\C=C/C\C=C/C/C=C\C/C=C\CCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml)

Preparing Stock Solutions

The following data is based on the product molecular weight 584.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.71 mL 8.55 mL 17.11 mL
5 mM 0.34 mL 1.71 mL 3.42 mL
10 mM 0.17 mL 0.86 mL 1.71 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Di Marzo et al (2002) A structure/activity relationship study on arvanil, an endocannabinoid and vanilloid hybrid. J.Pharmacol.Exp.Ther. 300 984 PMID: 11861807

Ligresti et al (2006) New potent and selective inhibitors of anandamide reuptake with antispastic activity in a mouse model of multiple sclerosis. Br.J.Pharmacol. 147 83 PMID: 16284631

Griffin et al (2001) Activity of a novel anandamide analog suggests a non-CB1, non-VR1 site of action. 2001 Symposium on the Cannabinoids, International PMID:


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Keywords: O-2093, supplier, inhibitors, inhibits, anandamide, reuptake, AMT, Transporters, Cannabinoids, Monoamine, Neurotransmitter, Cannabinoid, Transporters, Tocris Bioscience

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Literature in this Area

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Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

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Cannabinoid Receptor Ligands

Cannabinoid Receptor Ligands Scientific Review

Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.

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