O-2050

Discontinued Product

O-2050 (Cat. No. 1655) has been withdrawn from sale for commercial reasons.
Cat.No. 1655 - O-2050 | C23H31NO4S | CAS No. 1883545-42-3
Description: Putative CB1 antagonist; displays mixed activity at CB receptors
Chemical Name: (6aR,10aR)-1-Hydroxy-3-(1-Methanesulfonylamino-4-hexyn-6-yl)-6a,7,10,10a-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran
Purity: ≥97% (HPLC)
Datasheet
Citations (8)
Reviews
Literature (6)

Biological Activity for O-2050

O-2050 is an originally defined as a high affinity cannabinoid CB1 receptor silent antagonist. Acts as a partial agonist in inhibiting forksolin-induced cyclic AMP stimulation (EC50 = 40.4 nM). Decreases food intake and stimulates locomotor activity in rodents. Antagonizes effects of CP55,940 (Cat. No. 0949) in vitro.

Licensing Information

Sold under license from VCU-IPF

Technical Data for O-2050

M. Wt 417.56
Formula C23H31NO4S
Storage Store at -80°C
Purity ≥97% (HPLC)
CAS Number 1883545-42-3
PubChem ID 16102146
InChI Key DJTGGIYZQHHLGJ-RTBURBONSA-N
Smiles OC1=CC(CC#CCCCNS(=O)(C)=O)=CC3=[C@@]1[C@@H]2CC(C)=CC[C@H]2[C@@](C)(C)O3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for O-2050

Certificate of Analysis / Product Datasheet
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References for O-2050

References are publications that support the biological activity of the product.

Gardner and Mallet (2006) Suppression of feeding, drinking, and locomotion by a putative cannabinoid receptor 'silent antagonist.' Eur.J.Pharmacol. 530 103 PMID: 16380113

Martin et al (2002) Agonists and silent antagonists in a series of cannabinoid sulfonamides. Symposium on the Cannabinoids, International Canna

Wiley et al (2011) Structural and pharmacological analysis of O-2050, a putative neutral cannabinoid CB1 receptor antagonist. Eur.J.Pharmacol. 651 96 PMID: 21114999

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Keywords: O-2050, O-2050 supplier, CB1, silent, antagonists, cannabinoids, receptors, cb1r, receptor, Receptors, 1655, Tocris Bioscience

8 Citations for O-2050

Citations are publications that use Tocris products. Selected citations for O-2050 include:

Brents et al (2012) Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activity. Biochem Pharmacol 83 952 PMID: 22266354

Chimalakonda et al (2012) Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: identification of novel cannabinoid receptor ligands. Drug Metab Dispos 40 2174 PMID: 22904561

Prather et al (2013) CB1 and CB2 receptors are novel molecular targets for tamox. and 4OH-Tamoxifen. Biochem Biophys Res Commun 441 339 PMID: 24148245

Malenczyk et al (2013) CB1 cannabinoid receptors couple to focal adhesion kinase to control Ins release. J Biol Chem 288 32685 PMID: 24089517


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