NVS PAK1 C

Cat. No. 6133 Submit a Review Datasheet / COA / SDS

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Description: Negative control of NVS PAK1 1 (Cat. No. 6132)

Chemical Name: (3S)-3-(2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino)-N,N-dimethylpyrrolidine-1-carboxamide

Purity: ≥98% (HPLC)

Datasheet

Citations

Reviews

Literature (1)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for NVS PAK1 C

NVS PAK1 C is a negative control of NVS PAK1 1 (Cat. No. 6132), a potent and selective PAK1 inhibitor.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the NVS PAK1 1 probe summary on the SGC website.

Technical Data for NVS PAK1 C

M. Wt	465.91
Formula	C₂₂H₂₃ClF₃N₅O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2250019-95-3
PubChem ID	136590564
InChI Key	RVHZFZVJXGIAJF-HNNXBMFYSA-N
Smiles	FC(F)CN(C(C=CC(F)=C1)=C1N=C2N[C@H]3CCN(C(N(C)C)=O)C3)C4=C2C=C(Cl)C=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NVS PAK1 C

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	46.59	100
	ethanol	9.32	20

Preparing Stock Solutions for NVS PAK1 C

The following data is based on the product molecular weight 465.91. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.15 mL	10.73 mL	21.46 mL
5 mM	0.43 mL	2.15 mL	4.29 mL
10 mM	0.21 mL	1.07 mL	2.15 mL
50 mM	0.04 mL	0.21 mL	0.43 mL

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Product Datasheets for NVS PAK1 C

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for NVS PAK1 C

References are publications that support the biological activity of the product.

Karpov et al (2015) Optimization of a dibenzodiazepine hit to a potent and selective allosteric PAK1 inhibitor. ACS Med.Chem.Lett 6 776 PMID: 26191365

If you know of a relevant reference for NVS PAK1 C, please let us know.

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Keywords: NVS PAK1 C, NVS PAK1 C supplier, NVSPAK1C, PAK, 1, inhibitors, inhibits, naeative, control, P21-activated, Kinases, 6133, Tocris Bioscience

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Literature in this Area

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