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Description: Negative control of NVS PAK1 1 (Cat. No. 6132)
Chemical Name: (3S)-3-(2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino)-N,N-dimethylpyrrolidine-1-carboxamide
Purity: ≥98% (HPLC)

Biological Activity for NVS PAK1 C

NVS PAK1 C is a negative control of NVS PAK1 1 (Cat. No. 6132), a potent and selective PAK1 inhibitor.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the NVS PAK1 1 probe summary on the SGC website.

Technical Data for NVS PAK1 C

M. Wt 465.91
Formula C22H23ClF3N5O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2250019-95-3
PubChem ID 136590564
Smiles FC(F)CN(C(C=CC(F)=C1)=C1N=C2N[C@H]3CCN(C(N(C)C)=O)C3)C4=C2C=C(Cl)C=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NVS PAK1 C

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 46.59 100
ethanol 9.32 20

Preparing Stock Solutions for NVS PAK1 C

The following data is based on the product molecular weight 465.91. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.15 mL 10.73 mL 21.46 mL
5 mM 0.43 mL 2.15 mL 4.29 mL
10 mM 0.21 mL 1.07 mL 2.15 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

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References for NVS PAK1 C

References are publications that support the biological activity of the product.

Karpov et al (2015) Optimization of a dibenzodiazepine hit to a potent and selective allosteric PAK1 inhibitor. ACS Med.Chem.Lett 6 776 PMID: 26191365

If you know of a relevant reference for NVS PAK1 C, please let us know.

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Keywords: NVS PAK1 C, NVS PAK1 C supplier, NVSPAK1C, PAK, 1, inhibitors, inhibits, naeative, control, P21-activated, Kinases, 6133, Tocris Bioscience

Citations for NVS PAK1 C

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