Home / Pharmacology / Enzymes / Kinases / P21-activated Kinases / NVS PAK1 C

NVS PAK1 C

Cat. No. 6133 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Negative control of NVS PAK1 1 (Cat. No. 6132)
Chemical Name: (3S)-3-(2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino)-N,N-dimethylpyrrolidine-1-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for NVS PAK1 C

NVS PAK1 C is a negative control of NVS PAK1 1 (Cat. No. 6132), a potent and selective PAK1 inhibitor.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the NVS PAK1 1 probe summary on the SGC website.

Technical Data for NVS PAK1 C

M. Wt 465.91
Formula C22H23ClF3N5O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2250019-95-3
PubChem ID 136590564
InChI Key RVHZFZVJXGIAJF-HNNXBMFYSA-N
Smiles FC(F)CN(C(C=CC(F)=C1)=C1N=C2N[C@H]3CCN(C(N(C)C)=O)C3)C4=C2C=C(Cl)C=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NVS PAK1 C

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.59 100
ethanol 9.32 20

Preparing Stock Solutions for NVS PAK1 C

The following data is based on the product molecular weight 465.91. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.15 mL 10.73 mL 21.46 mL
5 mM 0.43 mL 2.15 mL 4.29 mL
10 mM 0.21 mL 1.07 mL 2.15 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for NVS PAK1 C

References are publications that support the biological activity of the product.

Karpov et al (2015) Optimization of a dibenzodiazepine hit to a potent and selective allosteric PAK1 inhibitor. ACS Med.Chem.Lett 6 776 PMID: 26191365

If you know of a relevant reference for NVS PAK1 C, please let us know.

View Related Products by Target

Keywords: NVS PAK1 C, NVS PAK1 C supplier, NVSPAK1C, PAK, 1, inhibitors, inhibits, naeative, control, P21-activated, Kinases, 6133, Tocris Bioscience

Citations for NVS PAK1 C

Citations are publications that use Tocris products.

Currently there are no citations for NVS PAK1 C. Do you know of a great paper that uses NVS PAK1 C from Tocris? Please let us know.

Reviews for NVS PAK1 C

There are currently no reviews for this product. Be the first to review NVS PAK1 C and earn rewards!

Have you used NVS PAK1 C?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
Kinases Product Listing

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases