Pricing Availability Delivery Time Qty
Cat.No. 6132 - NVS PAK1 1 | C23H25ClF3N5O | CAS No. 1783816-74-9
Description: Potent and selective PAK1 inhibitor
Chemical Name: (3S)-3-(2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino)-N-isopropylpyrrolidine-1-carboxamide
Purity: ≥98% (HPLC)

Biological Activity

Potent and selective PAK1 inhibitor (IC50 = 5 nM). Selective for PAK1 over PAK2 and a panel of 442 kinases. Inhibits autophosphorylation of PAK1 in KRAS-mutated pancreatic cancer cell lines.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the NVS-PAK1-1 probe summary on the SGC website.

Technical Data

M. Wt 479.93
Formula C23H25ClF3N5O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1783816-74-9
Smiles FC(F)CN(C(C=CC(F)=C1)=C1N=C2N[C@H]3CCN(C(NC(C)C)=O)C3)C4=C2C=C(Cl)C=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
1eq. HCl 47.99 100
DMSO 47.99 100
ethanol 47.99 100

Preparing Stock Solutions

The following data is based on the product molecular weight 479.93. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.08 mL 10.42 mL 20.84 mL
5 mM 0.42 mL 2.08 mL 4.17 mL
10 mM 0.21 mL 1.04 mL 2.08 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Karpov et al (2015) Optimization of a dibenzodiazepine hit to a potent and selective allosteric PAK1 inhibitor. ACS Med.Chem.Lett. 6 776 PMID: 26191365

If you know of a relevant reference for NVS PAK1 1, please let us know.

View Related Products by Target

View Related Products by Product Action

View all P21-activated Kinases Inhibitors

Keywords: NVS PAK1 1, supplier, NVSPAK11, P21-activated, kinases, PAK1, inhibitors, inhibits, potent, selective, P21-activated, Kinases, P21-activated, Kinases, Tocris Bioscience

Citations for NVS PAK1 1

Citations are publications that use Tocris products.

Currently there are no citations for NVS PAK1 1. Do you know of a great paper that uses NVS PAK1 1 from Tocris? If so please let us know.

Reviews for NVS PAK1 1

There are currently no reviews for this product. Be the first to review NVS PAK1 1 and earn rewards!

Have you used NVS PAK1 1?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases