NVP ADW 742
ATP-competitive inhibitor of IGF1R (IC50 in the range of 0.1-0.2 μM). Also inhibits c-Kit kinase activity (IC50 in the range of 3-5 μM). Exhibits a synergistic effect with Imatinib, enhancing the sensitivity of multiple small cell lung cancer cell lines to the chemotherapeutics etoposide (Cat. No. 1226) and carboplatin (Cat. No. 2626).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 453.58. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.41 mL||22.05 mL||44.09 mL|
|2.5 mM||0.88 mL||4.41 mL||8.82 mL|
|5 mM||0.44 mL||2.2 mL||4.41 mL|
|25 mM||0.09 mL||0.44 mL||0.88 mL|
References are publications that support the biological activity of the product.
Warshamana-Greene et al (2005) The Ins-like growth factor-I receptor kinase inhibitor, NVP-ADW742, sensitizes small cell lung cancer cell lines to the effects of chemotherapy. Clin.Cancer Res. 11 1563 PMID: 15746061
Warshamana-Greene et al (2004) The Ins-like growth factor-I (IGF-I) receptor kinase inhibitor NVP-ADW742, in combination with STI571, delineates a spectrum of dependence of small cell lung cancer on IGF-I and stem cell factor signaling. Mol.Cancer Ther. 3 527 PMID: 15141010
Zhou et al (2011) The Ins-like growth factor-I receptor kinase inhibitor NVP-ADW742 sensitizes medulloblastoma to the effects of chemotherapy. Oncol. Rep. 25 1565 PMID: 21455580
If you know of a relevant reference for NVP ADW 742, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: NVP ADW 742, NVP ADW 742 supplier, NVPADW742, ATP, competitive, inhibitors, inhibits, of, IGF1, receptors, kinases, c-Kit, small, cell, lung, cancer, lines, SCLC, insulin-like, growth, factor-1, receptor, Insulin, and, Receptors, Insulin-like, 5247, Tocris Bioscience
Citations for NVP ADW 742
Citations are publications that use Tocris products.
Currently there are no citations for NVP ADW 742. Do you know of a great paper that uses NVP ADW 742 from Tocris? Please let us know.
Reviews for NVP ADW 742
There are currently no reviews for this product. Be the first to review NVP ADW 742 and earn rewards!
Have you used NVP ADW 742?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.