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Biological Activity for NVP 231
NVP 231 is a potent, selective and reversible ceramide kinase (CerK) inhibitor (IC50 = 12 nM in vitro). Displays selectivity for CerK over sphingosine kinases (IC50 ≥100 μM) and other lipid kinases.
Compound Libraries for NVP 231
Technical Data for NVP 231
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NVP 231
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for NVP 231
The following data is based on the product molecular weight 431.55. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.32 mL||11.59 mL||23.17 mL|
|5 mM||0.46 mL||2.32 mL||4.63 mL|
|10 mM||0.23 mL||1.16 mL||2.32 mL|
|50 mM||0.05 mL||0.23 mL||0.46 mL|
References for NVP 231
References are publications that support the biological activity of the product.
Graf et al (2009) A secondary assay for ceramide kinase inhibitors based on cell growth inhibition by short-chain ceramides. Anal.Biochem. 384 166 PMID: 18831956
Niwa et al (2009) Ceramide kinase deficiency impairs microendothelial cell angiogenesis in vitro. Microvasc.Res. 77 389 PMID: 19323974
Graf et al (2009) Targeting ceramide metabolism with a potent and specific ceramide kinase inhibitor. Mol.Pharmacol. 74 925 PMID: 18612076
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Citations for NVP 231
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Literature in this Area
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