NU 1025
Biological Activity
Novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP). Ki and IC50 values are 48 and 400 nM respectively.
Compound Libraries
NU 1025 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 176.17 |
| Formula | C9H8N2O2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 90417-38-2 |
| PubChem ID | 63306 |
| InChI Key | YJDAOHJWLUNFLX-UHFFFAOYSA-N |
| Smiles | CC1=NC2=C(O)C=CC=C2C(=O)N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 17.62 | 100 | |
| 1eq. NaOH | 17.62 | 100 | |
| DMSO | 17.62 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 176.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.68 mL | 28.38 mL | 56.76 mL |
| 5 mM | 1.14 mL | 5.68 mL | 11.35 mL |
| 10 mM | 0.57 mL | 2.84 mL | 5.68 mL |
| 50 mM | 0.11 mL | 0.57 mL | 1.14 mL |
Molarity Calculator
Reconstitution Calculator
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Bowman et al (1998) Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064. Br.J.Cancer. 78 1269 PMID: 9823965
Delaney et al (2000) Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines. Clin.Cancer.Res. 6 2860 PMID: 10914735
Griffin et al (1998) Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP). J.Med.Chem. 41 5247 PMID: 9857092
If you know of a relevant reference for NU 1025, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Potent PARP inhibitors inhibits PolyADP-ribose Polymerases NU1025 Poly(ADP-ribose) Polymerase
Citations for NU 1025
Citations are publications that use Tocris products.
Currently there are no citations for NU 1025. Do you know of a great paper that uses NU 1025 from Tocris? If so please let us know.
Literature in this Area
Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis
Neurodegeneration Product Guide
A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:
- Alzheimer's disease
- Parkinson's disease
- Huntington's disease
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.
