NU 1025

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Cat.No. 1401 - NU 1025 | C9H8N2O2 | CAS No. 90417-38-2
Description: Potent PARP inhibitor
Chemical Name: 8-Hydroxy-2-methyl-4(3H)-quinazolinone
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP). Ki and IC50 values are 48 and 400 nM respectively.

Compound Libraries

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Technical Data

M. Wt 176.17
Formula C9H8N2O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 90417-38-2
PubChem ID 63306
InChI Key YJDAOHJWLUNFLX-UHFFFAOYSA-N
Smiles CC1=NC2=C(O)C=CC=C2C(=O)N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 17.62 100
1eq. NaOH 17.62 100
DMSO 17.62 100

Preparing Stock Solutions

The following data is based on the product molecular weight 176.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.68 mL 28.38 mL 56.76 mL
5 mM 1.14 mL 5.68 mL 11.35 mL
10 mM 0.57 mL 2.84 mL 5.68 mL
50 mM 0.11 mL 0.57 mL 1.14 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Bowman et al (1998) Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064. Br.J.Cancer. 78 1269 PMID: 9823965

Delaney et al (2000) Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines. Clin.Cancer.Res. 6 2860 PMID: 10914735

Griffin et al (1998) Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP). J.Med.Chem. 41 5247 PMID: 9857092


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Keywords: NU 1025, supplier, Potent, PARP, inhibitors, inhibits, PolyADP-ribose, Polymerases, NU1025, Poly(ADP-ribose), Polymerase, Poly(ADP-ribose), Polymerase, Tocris Bioscience

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