Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewNU 1025
Description: Potent PARP inhibitor
Chemical Name: 8-Hydroxy-2-methyl-4(3H)-quinazolinone
Purity: ≥99% (HPLC)
Biological Activity for NU 1025
NU 1025 is a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP). Ki and IC50 values are 48 and 400 nM respectively.
Technical Data for NU 1025
| M. Wt | 176.17 |
| Formula | C9H8N2O2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 90417-38-2 |
| PubChem ID | 63306 |
| InChI Key | YJDAOHJWLUNFLX-UHFFFAOYSA-N |
| Smiles | CC1=NC2=C(O)C=CC=C2C(=O)N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NU 1025
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. NaOH | 17.62 | 100 | |
| DMSO | 17.62 | 100 |
Preparing Stock Solutions for NU 1025
The following data is based on the product molecular weight 176.17. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.68 mL | 28.38 mL | 56.76 mL |
| 5 mM | 1.14 mL | 5.68 mL | 11.35 mL |
| 10 mM | 0.57 mL | 2.84 mL | 5.68 mL |
| 50 mM | 0.11 mL | 0.57 mL | 1.14 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for NU 1025
References for NU 1025
References are publications that support the biological activity of the product.
Bowman et al (1998) Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064. Br.J.Cancer. 78 1269 PMID: 9823965
Delaney et al (2000) Potentiation of temozol. and topo. growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines. Clin.Cancer.Res. 6 2860 PMID: 10914735
Griffin et al (1998) Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP). J.Med.Chem. 41 5247 PMID: 9857092
If you know of a relevant reference for NU 1025, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: NU 1025, NU 1025 supplier, Potent, PARP, inhibitors, inhibits, PolyADP-ribose, Polymerases, NU1025, Poly(ADP-ribose), Polymerase, 1401, Tocris Bioscience
1 Citation for NU 1025
Citations are publications that use Tocris products. Selected citations for NU 1025 include:
Sultana et al (2012) Synthetic lethal targeting of DNA double-strand break repair deficient cells by human apurinic/apyrimidinic endonuclease inhibitors. Int J Cancer 131 2433 PMID: 22377908
Do you know of a great paper that uses NU 1025 from Tocris? Please let us know.
Reviews for NU 1025
There are currently no reviews for this product. Be the first to review NU 1025 and earn rewards!
Have you used NU 1025?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis
Cell Cycle and DNA Damage Research Product GuideNew
This product guide provides a review of the cell cycle and DNA damage research area and lists over 170 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets
Neurodegeneration Product Guide
A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:
- Alzheimer's disease
- Parkinson's disease
- Huntington's disease
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.