NSC 697923

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Cat.No. 4858 - NSC 697923 | C11H9NO5S | CAS No. 343351-67-7
Description: Selective UBE2N inhibitor
Chemical Name: 2-[(4-Methylphenyl)sulfonyl]-5-nitrofuran
Purity: ≥98% (HPLC)

Biological Activity

Selective inhibitor of the E2 ubiquitin (Ub) conjugating enzyme UBE2N (Ubc13). Inhibits UBE2N-Ub conjugation and activity of the UBE2N-Ueva1A complex. Has no effect on UbcH5c activity. Inhibits NF-κB activation in diffuse large B-cell lymphoma (DLBCL) cells. Inhibits cell growth and induces apoptosis in DLBCL and neuroblastoma (NB) cell lines. Supresses NB cell xenograft tumor growth in vivo.

Compound Libraries

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Technical Data

M. Wt 267.26
Formula C11H9NO5S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 343351-67-7
PubChem ID 394449
Smiles CC(C=C2)=CC=C2S(C1=CC=C([N+]([O-])=O)O1)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 26.73 100
ethanol 6.68 25mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 267.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.74 mL 18.71 mL 37.42 mL
5 mM 0.75 mL 3.74 mL 7.48 mL
10 mM 0.37 mL 1.87 mL 3.74 mL
50 mM 0.07 mL 0.37 mL 0.75 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Pulvino et al (2012) Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A. Blood 120 1668 PMID: 22791293

Cheng et al (2014) A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways. Cell Death Dis. 5 e1079 PMID: 24556694

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View Related Products by Product Action

View all Ubiquitin/Ubl E2 Conjugating Enzyme Inhibitors

Keywords: NSC697923 E2 ubiquitin conjugating enzymes Ubc13 Uev1A NF-KB inhibitors proliferation survival lymphoma UBE2N NFκB NFkappaB antitumor inhibits Ubiquitin/Ubl E2 Conjugating Enzymes

Citations for NSC 697923

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Literature in this Area


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for NSC 697923


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