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NSC 697923

Cat. No. 4858 Submit a Review Datasheet / COA / SDS
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Description: Selective UBE2N inhibitor
Chemical Name: 2-[(4-Methylphenyl)sulfonyl]-5-nitrofuran
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for NSC 697923

NSC 697923 is a selective inhibitor of the E2 ubiquitin (Ub) conjugating enzyme UBE2N (Ubc13). Inhibits UBE2N-Ub conjugation and activity of the UBE2N-Ueva1A complex. Has no effect on UbcH5c activity. Inhibits NF-κB activation in diffuse large B-cell lymphoma (DLBCL) cells. Inhibits cell growth and induces apoptosis in DLBCL and neuroblastoma (NB) cell lines. Supresses NB cell xenograft tumor growth in vivo.

Technical Data for NSC 697923

M. Wt 267.26
Formula C11H9NO5S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 343351-67-7
PubChem ID 394449
InChI Key GAUHIPWCDXOLCZ-UHFFFAOYSA-N
Smiles CC(C=C2)=CC=C2S(C1=CC=C([N+]([O-])=O)O1)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NSC 697923

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.73 100
ethanol 6.68 25 with gentle warming

Preparing Stock Solutions for NSC 697923

The following data is based on the product molecular weight 267.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.74 mL 18.71 mL 37.42 mL
5 mM 0.75 mL 3.74 mL 7.48 mL
10 mM 0.37 mL 1.87 mL 3.74 mL
50 mM 0.07 mL 0.37 mL 0.75 mL

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References for NSC 697923

References are publications that support the biological activity of the product.

Pulvino et al (2012) Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A. Blood 120 1668 PMID: 22791293

Cheng et al (2014) A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways. Cell Death Dis. 5 e1079 PMID: 24556694

If you know of a relevant reference for NSC 697923, please let us know.

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Keywords: NSC 697923, NSC 697923 supplier, NSC697923, E2, ubiquitin, conjugating, enzymes, Ubc13, Uev1A, NF-KB, inhibitors, proliferation, survival, lymphoma, UBE2N, NFκB, NFkappaB, antitumor, inhibits, Post-translational, Modifications, Ubiquitin/Ubl, Conjugating, Enzymes, 4858, Tocris Bioscience

Citations for NSC 697923

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