NSC 697923

Discontinued Product

NSC 697923 (Cat. No. 4858) has been withdrawn from sale for commercial reasons.
Description: Selective UBE2N inhibitor
Chemical Name: 2-[(4-Methylphenyl)sulfonyl]-5-nitrofuran
Purity: ≥98% (HPLC)

Biological Activity for NSC 697923

NSC 697923 is a selective inhibitor of the E2 ubiquitin (Ub) conjugating enzyme UBE2N (Ubc13). Inhibits UBE2N-Ub conjugation and activity of the UBE2N-Ueva1A complex. Has no effect on UbcH5c activity. Inhibits NF-κB activation in diffuse large B-cell lymphoma (DLBCL) cells. Inhibits cell growth and induces apoptosis in DLBCL and neuroblastoma (NB) cell lines. Supresses NB cell xenograft tumor growth in vivo.

Technical Data for NSC 697923

M. Wt 267.26
Formula C11H9NO5S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 343351-67-7
PubChem ID 394449
Smiles CC(C=C2)=CC=C2S(C1=CC=C([N+]([O-])=O)O1)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for NSC 697923

References are publications that support the biological activity of the product.

Pulvino et al (2012) Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A. Blood 120 1668 PMID: 22791293

Cheng et al (2014) A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways. Cell Death Dis. 5 e1079 PMID: 24556694

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Keywords: NSC 697923, NSC 697923 supplier, NSC697923, E2, ubiquitin, conjugating, enzymes, Ubc13, Uev1A, NF-KB, inhibitors, proliferation, survival, lymphoma, UBE2N, NFκB, NFkappaB, antitumor, inhibits, Post-translational, Modifications, Ubiquitin/Ubl, Conjugating, Enzymes, 4858, Tocris Bioscience

Citations for NSC 697923

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Currently there are no citations for NSC 697923.

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