NSC 697923

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Cat.No. 4858 - NSC 697923 | C11H9NO5S | CAS No. 343351-67-7
Description: Selective UBE2N inhibitor
Chemical Name: 2-[(4-Methylphenyl)sulfonyl]-5-nitrofuran
Purity: ≥98% (HPLC)
Datasheet
Citations
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Literature

Biological Activity

Selective inhibitor of the E2 ubiquitin (Ub) conjugating enzyme UBE2N (Ubc13). Inhibits UBE2N-Ub conjugation and activity of the UBE2N-Ueva1A complex. Has no effect on UbcH5c activity. Inhibits NF-κB activation in diffuse large B-cell lymphoma (DLBCL) cells. Inhibits cell growth and induces apoptosis in DLBCL and neuroblastoma (NB) cell lines. Supresses NB cell xenograft tumor growth in vivo.

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Technical Data

M. Wt 267.26
Formula C11H9NO5S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 343351-67-7
PubChem ID 394449
InChI Key GAUHIPWCDXOLCZ-UHFFFAOYSA-N
Smiles CC(C=C2)=CC=C2S(C1=CC=C([N+]([O-])=O)O1)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 6.68 25 with gentle warming
DMSO 26.73 100

Preparing Stock Solutions

The following data is based on the product molecular weight 267.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.74 mL 18.71 mL 37.42 mL
5 mM 0.75 mL 3.74 mL 7.48 mL
10 mM 0.37 mL 1.87 mL 3.74 mL
50 mM 0.07 mL 0.37 mL 0.75 mL

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References

References are publications that support the biological activity of the product.

Pulvino et al (2012) Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A. Blood 120 1668 PMID: 22791293

Cheng et al (2014) A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways. Cell Death Dis. 5 e1079 PMID: 24556694


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View Related Products by Product Action

View all Ubiquitin/Ubl E2 Conjugating Enzyme Inhibitors

Keywords: NSC 697923, NSC 697923 supplier, NSC697923, E2, ubiquitin, conjugating, enzymes, Ubc13, Uev1A, NF-KB, inhibitors, proliferation, survival, lymphoma, UBE2N, NFκB, NFkappaB, antitumor, inhibits, Post-translational, Modifications, Ubiquitin/Ubl, Conjugating, Enzymes, 4858, Tocris Bioscience

Citations for NSC 697923

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