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Selective inhibitor of the E2 ubiquitin (Ub) conjugating enzyme UBE2N (Ubc13). Inhibits UBE2N-Ub conjugation and activity of the UBE2N-Ueva1A complex. Has no effect on UbcH5c activity. Inhibits NF-κB activation in diffuse large B-cell lymphoma (DLBCL) cells. Inhibits cell growth and induces apoptosis in DLBCL and neuroblastoma (NB) cell lines. Supresses NB cell xenograft tumor growth in vivo.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|ethanol||6.68||25 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 267.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.74 mL||18.71 mL||37.42 mL|
|5 mM||0.75 mL||3.74 mL||7.48 mL|
|10 mM||0.37 mL||1.87 mL||3.74 mL|
|50 mM||0.07 mL||0.37 mL||0.75 mL|
References are publications that support the biological activity of the product.
Pulvino et al (2012) Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A. Blood 120 1668 PMID: 22791293
Cheng et al (2014) A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways. Cell Death Dis. 5 e1079 PMID: 24556694
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Keywords: NSC 697923, NSC 697923 supplier, NSC697923, E2, ubiquitin, conjugating, enzymes, Ubc13, Uev1A, NF-KB, inhibitors, proliferation, survival, lymphoma, UBE2N, NFκB, NFkappaB, antitumor, inhibits, Post-translational, Modifications, Ubiquitin/Ubl, Conjugating, Enzymes, 4858, Tocris Bioscience
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