Wnt signaling inhibitor. Binds the PDZ domain of the Dishevelled (Dvl) protein. Inhibits proliferation, migration and TGF-β-induced differentiation of fibroblasts in vitro. Reduces severity of pulmonary fibrosis in a mouse model.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 460.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.17 mL||10.86 mL||21.71 mL|
|5 mM||0.43 mL||2.17 mL||4.34 mL|
|10 mM||0.22 mL||1.09 mL||2.17 mL|
|50 mM||0.04 mL||0.22 mL||0.43 mL|
References are publications that support the biological activity of the product.
Shan et al (2005) Identification of a specific inhibitor of the dishevelled PDZ domain. Biochemistry 44 15495 PMID: 16300398
Wang et al (2015) Targeted inhibition of disheveled PDZ domain via NSC668036 depresses fibrotic process. Exp.Cell Res. 331 115 PMID: 25445788
If you know of a relevant reference for NSC 668036, please let us know.
View Related Products by Product Action
Keywords: NSC 668036, NSC 668036 supplier, NSC668036, Wnt, signaling, inhibitors, inhibits, PDZ, domain, Dishevelled, Dvl, β, beta-catenin, Other, Signaling, 5813, Tocris Bioscience
Citations for NSC 668036
Citations are publications that use Tocris products.
Currently there are no citations for NSC 668036. Do you know of a great paper that uses NSC 668036 from Tocris? Please let us know.
Reviews for NSC 668036
There are currently no reviews for this product. Be the first to review NSC 668036 and earn rewards!
Have you used NSC 668036?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.