NSC 668036

Pricing Availability   Qty
Cat.No. 5813 - NSC 668036 | C21H36N2O9 | CAS No. 144678-63-7
Description: Wnt signaling inhibitor; binds the PDZ domain of the Dishevelled (Dvl) protein
Chemical Name: N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl-(2S)-2-hydroxy-3-methylbutanoyl-L-alanine-(1S)-1-carboxy-2-methylpropyl ester
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature
Pathways

Biological Activity

Wnt signaling inhibitor. Binds the PDZ domain of the Dishevelled (Dvl) protein. Inhibits proliferation, migration and TGF-β-induced differentiation of fibroblasts in vitro. Reduces severity of pulmonary fibrosis in a mouse model.

Technical Data

M. Wt 460.52
Formula C21H36N2O9
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 144678-63-7
PubChem ID 71312060
InChI Key IPICFSFUAKDZEI-AJNGGQMLSA-N
Smiles CC([C@@H](C(O)=O)OC([C@@H](NC([C@H](C(C)C)OC([C@@H](NC(OC(C)(C)C)=O)C)=O)=O)C)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 46.05 100
DMSO 46.05 100

Preparing Stock Solutions

The following data is based on the product molecular weight 460.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.17 mL 10.86 mL 21.71 mL
5 mM 0.43 mL 2.17 mL 4.34 mL
10 mM 0.22 mL 1.09 mL 2.17 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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References

References are publications that support the biological activity of the product.

Shan et al (2005) Identification of a specific inhibitor of the dishevelled PDZ domain. Biochemistry 44 15495 PMID: 16300398

Wang et al (2015) Targeted inhibition of disheveled PDZ domain via NSC668036 depresses fibrotic process. Exp.Cell Res. 331 115 PMID: 25445788


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Keywords: NSC 668036, NSC 668036 supplier, NSC668036, Wnt, signaling, inhibitors, inhibits, PDZ, domain, Dishevelled, Dvl, β, beta-catenin, Other, Signaling, 5813, Tocris Bioscience

Citations for NSC 668036

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Literature in this Area

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Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for NSC 668036

Wnt

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.