NSC 319726

Pricing Availability Delivery Time Qty
Cat.No. 5065 - NSC 319726 | C11H14N4S | CAS No. 71555-25-4
Description: Reactivator of mutant p53
Chemical Name: 1-Azetidinecarbothioic acid [1-(2-pyridinyl)ethylidene]hydrazide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature
Pathways

Biological Activity

Reactivator of mutant p53. Restores wild type p53 structure and function to the p53R175 mutant. Inhibits growth of fibroblasts expressing the p53R175 mutation (IC50 = 8 nM). Also inhibits growth of xenograft tumors expressing the p53R175 mutation in vivo.

Compound Libraries

NSC 319726 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 234.32
Formula C11H14N4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 71555-25-4
PubChem ID 5351307
InChI Key XDHBUMNIQRLHGO-UKTHLTGXSA-N
Smiles C/C(C1=NC=CC=C1)=N\NC(N2CCC2)=S

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.43 100
ethanol 2.34 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 234.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.27 mL 21.34 mL 42.68 mL
5 mM 0.85 mL 4.27 mL 8.54 mL
10 mM 0.43 mL 2.13 mL 4.27 mL
50 mM 0.09 mL 0.43 mL 0.85 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Yu et al (2012) Allele-specific p53 mutant reactivation. Cancer Cell 21 614 PMID: 22624712


If you know of a relevant reference for NSC 319726, please let us know.

View Related Products by Target

View Related Products by Product Action

View all p53 Activators

Keywords: NSC 319726, supplier, NSC319726, mutant, p53, reactivators, activators, p53R175, transcription, factors, cell, cycle, apoptosis, p53, Tocris Bioscience

Citations for NSC 319726

Citations are publications that use Tocris products.

Currently there are no citations for NSC 319726. Do you know of a great paper that uses NSC 319726 from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cell Cycle & DNA Damage Repair

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Pathways for NSC 319726

p53

p53 Signaling Pathway

p53 signaling plays an important role in the co-ordination of the cellular response different types of stress such as DNA damage and hypoxia. The downstream signals lead to apoptosis, senescence and cell cycle arrest.

Protocols

TODO: Add Protocols