NSC 319726

Discontinued Product

NSC 319726 (Cat. No. 5065) has been withdrawn from sale for commercial reasons.
Description: Reactivator of mutant p53
Chemical Name: 1-Azetidinecarbothioic acid [1-(2-pyridinyl)ethylidene]hydrazide
Purity: ≥98% (HPLC)
Literature (2)
Pathways (1)

Biological Activity for NSC 319726

NSC 319726 is a reactivator of mutant p53. Restores wild type p53 structure and function to the p53R175 mutant. Inhibits growth of fibroblasts expressing the p53R175 mutation (IC50 = 8 nM). Also inhibits growth of xenograft tumors expressing the p53R175 mutation in vivo.

Technical Data for NSC 319726

M. Wt 234.32
Formula C11H14N4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 71555-25-4
PubChem ID 5351307
Smiles C/C(C1=NC=CC=C1)=N\NC(N2CCC2)=S

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for NSC 319726

References are publications that support the biological activity of the product.

Yu et al (2012) Allele-specific p53 mutant reactivation. Cancer Cell 21 614 PMID: 22624712

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Keywords: NSC 319726, NSC 319726 supplier, NSC319726, mutant, p53, reactivators, activators, p53R175, transcription, factors, cell, cycle, apoptosis, 5065, Tocris Bioscience

Citations for NSC 319726

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Currently there are no citations for NSC 319726.

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Literature in this Area

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Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Pathways for NSC 319726

p53 Signaling Pathway

p53 Signaling Pathway

p53 signaling plays an important role in the co-ordination of the cellular response different types of stress such as DNA damage and hypoxia. The downstream signals lead to apoptosis, senescence and cell cycle arrest.