Reactivator of mutant p53. Restores wild type p53 structure and function to the p53R175 mutant. Inhibits growth of fibroblasts expressing the p53R175 mutation (IC50 = 8 nM). Also inhibits growth of xenograft tumors expressing the p53R175 mutation in vivo.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|ethanol||2.34||10mM with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 234.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.27 mL||21.34 mL||42.68 mL|
|5 mM||0.85 mL||4.27 mL||8.54 mL|
|10 mM||0.43 mL||2.13 mL||4.27 mL|
|50 mM||0.09 mL||0.43 mL||0.85 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Yu et al (2012) Allele-specific p53 mutant reactivation. Cancer Cell 21 614 PMID: 22624712
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Keywords: NSC 319726, supplier, NSC319726, mutant, p53, reactivators, activators, p53R175, transcription, factors, cell, cycle, apoptosis, p53, Tocris Bioscience
Citations for NSC 319726
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In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.