NS 8593 hydrochloride

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Description: Selective negative modulator of KCa2 (SK) channels; inhibits SK currents
Chemical Name: N-[(1R)-1,2,3,4-Tetrahydro-1-naphthalenyl]-1H-benzimidazol-2-amine hydrochloride
Purity: ≥98% (HPLC)
Citations (3)
Reviews (1)

Biological Activity for NS 8593 hydrochloride

NS 8593 hydrochloride is a selective KCa2 (SK) channel negative modulator; inhibits SK channel currents (Kd values are 0.42, 0.6 and 0.73 μM for SK1, SK2 and SK3 respectively at 0.5 μM Ca2+). Exhibits selectivity for SK channels over KCa1.1 (BK), KCa3.1 (IK), Kv, Nav and Cav channels. Inhibits afterhyperpolarization in hippocampal slices.

Compound Libraries for NS 8593 hydrochloride

NS 8593 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for NS 8593 hydrochloride

M. Wt 299.8
Formula C17H17N3.HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 875755-24-1
PubChem ID 71311765
Smiles C12=CC=CC=C1N=C(N[C@H]3C(C=CC=C4)=C4CCC3)N2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NS 8593 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 29.98 100
ethanol 6 20

Preparing Stock Solutions for NS 8593 hydrochloride

The following data is based on the product molecular weight 299.8. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.34 mL 16.68 mL 33.36 mL
5 mM 0.67 mL 3.34 mL 6.67 mL
10 mM 0.33 mL 1.67 mL 3.34 mL
50 mM 0.07 mL 0.33 mL 0.67 mL

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Product Datasheets for NS 8593 hydrochloride

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3 Citations for NS 8593 hydrochloride

Citations are publications that use Tocris products. Selected citations for NS 8593 hydrochloride include:

Schmidt et al (2022) Structural mechanism of TRPM7 channel regulation by intracellular magnesium Cell Mol Life Sci 79 225 PMID: 35389104

Yi et al (2020) TRPM7 activation potentiates SOCE in enamel cells but requires ORAI. Cell Calcium 87 102187 PMID: 32146159

Tian et al (2018) Prostaglandin E2 increases migration and proliferation of human glioblastoma cells by activating transient receptor potential melastatin 7 channels. J Cell Mol Med 22 6327 PMID: 30338939

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Reviews for NS 8593 hydrochloride

Average Rating: 5 (Based on 1 Review.)

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NS 8593 worked great on experimental conditions.
By Sadequl Islam on 10/13/2018
Assay Type: In Vivo
Species: Mouse

Product was used to study SK channel activity. Shows channel blocking activity and reduced Calcium activated opening. Great product, performs well and stable.

The product was dissolved in DMSO. Sterile DMSO must be used for sterile cell culture studies.

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