NS 6740

Pricing Availability   Qty
Description: High affinity α7 nAChR partial agonist; anti-inflammatory
Chemical Name: 1,4-Diazabicyclo[3.2.2]non-4-yl[5-[3-(trifluoromethyl)phenyl]-2-furanyl]methanone hydrochloride
Purity: ≥98% (HPLC)
Literature (5)

Biological Activity for NS 6740

NS 6740 is a high affinity α7 nAChR partial agonist (Ki = 1.1 nM in rat; Emax < 10% of the response to ACh in rat and human). Inhibits ACh (IC50 = 2.7 nM) at α7 nAChR. Reduces LPS-induced TNF-α release from microglia enriched cultures. Anti-inflammatory.

Technical Data for NS 6740

M. Wt 400.82
Formula C19H19F3N2O2.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 753499-14-8
PubChem ID 68676769
Smiles O=C(N1CCN2CCC1CC2)C(O3)=CC=C3C4=CC(C(F)(F)F)=CC=C4.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NS 6740

Solvent Max Conc. mg/mL Max Conc. mM
water 40.08 100
DMSO 20.04 50

Preparing Stock Solutions for NS 6740

The following data is based on the product molecular weight 400.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.49 mL 12.47 mL 24.95 mL
5 mM 0.5 mL 2.49 mL 4.99 mL
10 mM 0.25 mL 1.25 mL 2.49 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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References for NS 6740

References are publications that support the biological activity of the product.

Briggs et al (2009) Role of channel activation in cognitive enhancement mediated by α7 nicotinic acetylcholine receptors. Br.J.Pharmacol. 158 1486 PMID: 19845675

Thomsen et al (2012) The α7 nicotinic acetylcholine receptor ligands methyllycaconitine, NS6740 and GTS-21 reduce lipopolysaccharide-induced TNF-α release from microglia. J.Neuroimmunol. 251 65 PMID: 22884467

Papke et al (2015) The analgesic-like properties of the alpha7 nAChR silent agonist NS6740 is associated with non-conducting conformations of the receptor. Neuropharmacology 91 34 PMID: 25497451

If you know of a relevant reference for NS 6740, please let us know.

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Citations for NS 6740

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Currently there are no citations for NS 6740. Do you know of a great paper that uses NS 6740 from Tocris? Please let us know.

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