NS 6740

Discontinued Product

NS 6740 (Cat. No. 6139) has been withdrawn from sale for commercial reasons.
Description: High affinity α7 nAChR partial agonist; anti-inflammatory
Chemical Name: 1,4-Diazabicyclo[3.2.2]non-4-yl[5-[3-(trifluoromethyl)phenyl]-2-furanyl]methanone hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity for NS 6740

NS 6740 is a high affinity α7 nAChR partial agonist (Ki = 1.1 nM in rat; Emax < 10% of the response to ACh in rat and human). Inhibits ACh (IC50 = 2.7 nM) at α7 nAChR. Reduces LPS-induced TNF-α release from microglia enriched cultures. Anti-inflammatory.

Technical Data for NS 6740

M. Wt 400.82
Formula C19H19F3N2O2.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 753499-14-8
PubChem ID 68676769
InChI Key QHSRBONTAYCFCC-UHFFFAOYSA-N
Smiles O=C(N1CCN2CCC1CC2)C(O3)=CC=C3C4=CC(C(F)(F)F)=CC=C4.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for NS 6740

References are publications that support the biological activity of the product.

Briggs et al (2009) Role of channel activation in cognitive enhancement mediated by α7 nicotinic acetylcholine receptors. Br.J.Pharmacol. 158 1486 PMID: 19845675

Thomsen et al (2012) The α7 nicotinic acetylcholine receptor ligands methyllycaconitine, NS6740 and GTS-21 reduce lipopolysaccharide-induced TNF-α release from microglia. J.Neuroimmunol. 251 65 PMID: 22884467

Papke et al (2015) The analgesic-like properties of the alpha7 nAChR silent agonist NS6740 is associated with non-conducting conformations of the receptor. Neuropharmacology 91 34 PMID: 25497451

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Keywords: NS 6740, NS 6740 supplier, NS6740, alpha7, a7, nicotinics, acetylcholine, receptors, partial, agonists, agonism, silent, anti-inflammatory, high, affinity, Nicotinic, (a7), Receptors, 6139, Tocris Bioscience

Citations for NS 6740

Citations are publications that use Tocris products.

Currently there are no citations for NS 6740.

Reviews for NS 6740

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Nicotinic ACh Receptors Scientific Review

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.

Alzheimer's Disease Poster

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.