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Submit ReviewNS 6740 is a high affinity α7 nAChR partial agonist (Ki = 1.1 nM in rat; Emax < 10% of the response to ACh in rat and human). Inhibits ACh (IC50 = 2.7 nM) at α7 nAChR. Reduces LPS-induced TNF-α release from microglia enriched cultures. Anti-inflammatory.
M. Wt | 400.82 |
Formula | C19H19F3N2O2.HCl |
Storage | Store at RT |
Purity | ≥98% (HPLC) |
CAS Number | 753499-14-8 |
PubChem ID | 68676769 |
InChI Key | QHSRBONTAYCFCC-UHFFFAOYSA-N |
Smiles | O=C(N1CCN2CCC1CC2)C(O3)=CC=C3C4=CC(C(F)(F)F)=CC=C4.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
water | 40.08 | 100 | |
DMSO | 20.04 | 50 |
The following data is based on the product molecular weight 400.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.49 mL | 12.47 mL | 24.95 mL |
5 mM | 0.5 mL | 2.49 mL | 4.99 mL |
10 mM | 0.25 mL | 1.25 mL | 2.49 mL |
50 mM | 0.05 mL | 0.25 mL | 0.5 mL |
References are publications that support the biological activity of the product.
Briggs et al (2009) Role of channel activation in cognitive enhancement mediated by α7 nicotinic acetylcholine receptors. Br.J.Pharmacol. 158 1486 PMID: 19845675
Thomsen et al (2012) The α7 nicotinic acetylcholine receptor ligands methyllycaconitine, NS6740 and GTS-21 reduce lipopolysaccharide-induced TNF-α release from microglia. J.Neuroimmunol. 251 65 PMID: 22884467
Papke et al (2015) The analgesic-like properties of the alpha7 nAChR silent agonist NS6740 is associated with non-conducting conformations of the receptor. Neuropharmacology 91 34 PMID: 25497451
If you know of a relevant reference for NS 6740, please let us know.
Keywords: NS 6740, NS 6740 supplier, NS6740, alpha7, a7, nicotinics, acetylcholine, receptors, partial, agonists, agonism, silent, anti-inflammatory, high, affinity, Nicotinic, (a7), Receptors, 6139, Tocris Bioscience
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.
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