NS 3861

Pricing Availability Delivery Time Qty
Cat.No. 4831 - NS 3861 | C12H14BrNS.C4H4O4 | CAS No. 216853-60-0
Description: α3β2 full agonist; also α3β4 partial agonist
Chemical Name: 3-(3-Bromo-2-thienyl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene fumarate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

α3β2 full agonist (EC50 = 1.6 μM). Also α3β4 partial agonist (EC50 = 1 μM). Exhibits minimal activity at α4β2 and α4β4. Displays high affinity for α3β4, α4β4, α3β2 and α4β2 (Ki values are 0.62, 7.8, 25 and 55 nM respectively).

Compound Libraries

NS 3861 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 400.29
Formula C12H14BrNS.C4H4O4
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 216853-60-0
PubChem ID 91826078
InChI Key KXBSQPLWTVQFGJ-WLHGVMLRSA-N
Smiles CN1C2CCC1CC(C3=C(Br)C=CS3)=C2.OC(/C=C/C(O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.03 100
water 20.01 50

Preparing Stock Solutions

The following data is based on the product molecular weight 400.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.5 mL 12.49 mL 24.98 mL
5 mM 0.5 mL 2.5 mL 5 mL
10 mM 0.25 mL 1.25 mL 2.5 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Harpsøe et al (2013) Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors. J.Biol.Chem. 288 2559 PMID: 23229547


If you know of a relevant reference for NS 3861, please let us know.

View Related Products by Product Action

View all Nicotinic Receptor (Other Subtype) Agonists

Keywords: NS 3861, supplier, NS3861, alpha3beta2, a3b2, α3β2, alpha3beta4, a3b4, α3β4, agonists, partial, Nicotinic, Receptors, (Other, Subtypes), Nicotinic, Receptors, (Other, Subtypes), Tocris Bioscience

Citations for NS 3861

Citations are publications that use Tocris products.

Currently there are no citations for NS 3861. Do you know of a great paper that uses NS 3861 from Tocris? If so please let us know.

Reviews for NS 3861

There are currently no reviews for this product. Be the first to review NS 3861 and earn rewards!

Have you used NS 3861?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Nicotinic ACh Receptors

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.

Pain

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.