NS 3861

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Description: α3β2 full agonist; also α3β4 partial agonist
Chemical Name: 3-(3-Bromo-2-thienyl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene fumarate
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for NS 3861

NS 3861 is a α3β2 full agonist (EC50 = 1.6 μM). Also α3β4 partial agonist (EC50 = 1 μM). Exhibits minimal activity at α4β2 and α4β4. Displays high affinity for α3β4, α4β4, α3β2 and α4β2 (Ki values are 0.62, 7.8, 25 and 55 nM respectively).

Technical Data for NS 3861

M. Wt 400.29
Formula C12H14BrNS.C4H4O4
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 216853-60-0
PubChem ID 91826078
Smiles CN1C2CCC1CC(C3=C(Br)C=CS3)=C2.OC(/C=C/C(O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NS 3861

Solvent Max Conc. mg/mL Max Conc. mM
water 20.01 50
DMSO 40.03 100

Preparing Stock Solutions for NS 3861

The following data is based on the product molecular weight 400.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.5 mL 12.49 mL 24.98 mL
5 mM 0.5 mL 2.5 mL 5 mL
10 mM 0.25 mL 1.25 mL 2.5 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets for NS 3861

Certificate of Analysis / Product Datasheet
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References for NS 3861

References are publications that support the biological activity of the product.

Harpsøe et al (2013) Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors. J.Biol.Chem. 288 2559 PMID: 23229547

If you know of a relevant reference for NS 3861, please let us know.

View Related Products by Product Action

View all Nicotinic Receptor (Other Subtype) Agonists

Keywords: NS 3861, NS 3861 supplier, NS3861, alpha3beta2, a3b2, α3β2, alpha3beta4, a3b4, α3β4, agonists, partial, Nicotinic, Receptors, (Other, Subtypes), 4831, Tocris Bioscience

Citations for NS 3861

Citations are publications that use Tocris products.

Currently there are no citations for NS 3861. Do you know of a great paper that uses NS 3861 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Nicotinic ACh Receptors Scientific Review

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.