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Biological Activity for NS 3861
NS 3861 is a α3β2 full agonist (EC50 = 1.6 μM). Also α3β4 partial agonist (EC50 = 1 μM). Exhibits minimal activity at α4β2 and α4β4. Displays high affinity for α3β4, α4β4, α3β2 and α4β2 (Ki values are 0.62, 7.8, 25 and 55 nM respectively).
Technical Data for NS 3861
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NS 3861
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for NS 3861
The following data is based on the product molecular weight 400.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.5 mL||12.49 mL||24.98 mL|
|5 mM||0.5 mL||2.5 mL||5 mL|
|10 mM||0.25 mL||1.25 mL||2.5 mL|
|50 mM||0.05 mL||0.25 mL||0.5 mL|
References for NS 3861
References are publications that support the biological activity of the product.
Harpsøe et al (2013) Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors. J.Biol.Chem. 288 2559 PMID: 23229547
If you know of a relevant reference for NS 3861, please let us know.
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Keywords: NS 3861, NS 3861 supplier, NS3861, alpha3beta2, a3b2, α3β2, alpha3beta4, a3b4, α3β4, agonists, partial, Nicotinic, Receptors, (Other, Subtypes), 4831, Tocris Bioscience
Citations for NS 3861
Citations are publications that use Tocris products.
Currently there are no citations for NS 3861. Do you know of a great paper that uses NS 3861 from Tocris? Please let us know.
Reviews for NS 3861
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Literature in this Area
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