NS 3763

Discontinued Product

NS 3763 (Cat. No. 2187) has been withdrawn from sale for commercial reasons.
Cat.No. 2187 - NS 3763 | C22H16N2O6 | CAS No. 70553-45-6
Description: GluK1 selective and non-competitive kainate antagonist
Chemical Name: 4,6-Bis(benzoylamino)-1,3-benzenedicarboxylic acid
Purity: ≥98% (HPLC)
Reviews (1)
Literature (8)

Biological Activity for NS 3763

Selective non-competitive kainate receptor antagonist; displays selectivity for GluK1 (formerly GLUK5) subunit-containing receptors (IC50 values are 1.6 and > 30 μM for homomeric GluK1 (formerly GLUK5) and GluK2 (formerly GLUK6) receptors respectively). Has minimal activity at AMPA and NMDA receptors (IC50> 30 μM).

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Technical Data for NS 3763

M. Wt 404.38
Formula C22H16N2O6
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 70553-45-6
PubChem ID 4359312
Smiles O=C(C2=CC=CC=C2)NC1=CC(NC(C3=CC=CC=C3)=O)=C(C(O)=O)C=C1C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for NS 3763

Certificate of Analysis / Product Datasheet
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References for NS 3763

References are publications that support the biological activity of the product.

Christensen et al (2004) In vitro characterization of 5-carboxyl-2,4-di-benzamido-benzoic acid (NS3763), a noncompetitive antagonist of GLUK5 receptors. J.Pharmacol.Exp.Ther. 309 1003 PMID: 14985418

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Keywords: NS 3763, NS 3763 supplier, Selective, non-competitive, kainate, antagonists, selective, GLUK5, Glutamate, Kainate, Receptors, iGluR, Ionotropic, NS3763, GluK1, 2187, Tocris Bioscience

Citations for NS 3763

Citations are publications that use Tocris products.

Currently there are no citations for NS 3763.

Reviews for NS 3763

Average Rating: 4 (Based on 1 Review.)

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NS 3763 was studied to determine its NMDA effect:Product works well and the results publishable.
By Sadequl Islam on 10/12/2018
Assay Type: In Vitro
Species: Human

NS 3763 performed extremely well when tested for NMDA activity. The correlation of NS 3763 was studied in respect to its effect with NMDA regulation.

The NS 3763 cannot be dissolved in aqueous media and must be dissolved in DMSO. For sterile conditions/study, sterile DMSO is mandatory.

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