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Selective non-competitive kainate receptor antagonist; displays selectivity for GluK1 (formerly GLUK5) subunit-containing receptors (IC50 values are 1.6 and > 30 μM for homomeric GluK1 (formerly GLUK5) and GluK2 (formerly GLUK6) receptors respectively). Has minimal activity at AMPA and NMDA receptors (IC50> 30 μM).
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 404.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.25 mM||9.89 mL||49.46 mL||98.92 mL|
|1.25 mM||1.98 mL||9.89 mL||19.78 mL|
|2.5 mM||0.99 mL||4.95 mL||9.89 mL|
|12.5 mM||0.2 mL||0.99 mL||1.98 mL|
References are publications that support the biological activity of the product.
Christensen et al (2004) In vitro characterization of 5-carboxyl-2,4-di-benzamido-benzoic acid (NS3763), a noncompetitive antagonist of GLUK5 receptors. J.Pharmacol.Exp.Ther. 309 1003 PMID: 14985418
If you know of a relevant reference for NS 3763, please let us know.
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Keywords: NS 3763, NS 3763 supplier, Selective, non-competitive, kainate, antagonists, selective, GLUK5, Glutamate, Kainate, Receptors, iGluR, Ionotropic, NS3763, GluK1, 2187, Tocris Bioscience
Citations for NS 3763
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Reviews for NS 3763
Average Rating: 4 (Based on 1 Review.)
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NS 3763 performed extremely well when tested for NMDA activity. The correlation of NS 3763 was studied in respect to its effect with NMDA regulation.
The NS 3763 cannot be dissolved in aqueous media and must be dissolved in DMSO. For sterile conditions/study, sterile DMSO is mandatory.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.
Learning & Memory Poster
Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.