NS 3763

Pricing Availability Delivery Time Qty
Cat.No. 2187 - NS 3763 | C22H16N2O6 | CAS No. 70553-45-6
Description: Selective non-competitive kainate antagonist; selective for GLUK5
Chemical Name: 4,6-Bis(benzoylamino)-1,3-benzenedicarboxylic acid
Purity: ≥98% (HPLC)

Biological Activity

Selective non-competitive kainate receptor antagonist; displays selectivity for GLUK5 subunit-containing receptors (IC50 values are 1.6 and > 30 μM for homomeric GLUK5 and GLUK6 receptors respectively). Has minimal activity at AMPA and NMDA receptors (IC50> 30 μM).

Technical Data

M. Wt 404.38
Formula C22H16N2O6
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 70553-45-6
PubChem ID 4359312
Smiles O=C(C2=CC=CC=C2)NC1=CC(NC(C3=CC=CC=C3)=O)=C(C(O)=O)C=C1C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 10.11 25

Preparing Stock Solutions

The following data is based on the product molecular weight 404.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.47 mL 12.36 mL 24.73 mL
5 mM 0.49 mL 2.47 mL 4.95 mL
10 mM 0.25 mL 1.24 mL 2.47 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet


References are publications that support the products' biological activity.

Christensen et al (2004) In vitro characterization of 5-carboxyl-2,4-di-benzamido-benzoic acid (NS3763), a noncompetitive antagonist of GLUK5 receptors. J.Pharmacol.Exp.Ther. 309 1003 PMID: 14985418

If you know of a relevant reference for NS 3763, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Kainate Receptor Antagonists

Keywords: NS 3763, supplier, Selective, non-competitive, kainate, antagonists, selective, GLUK5, Glutamate, Kainate, Receptors, iGluR, Ionotropic, NS3763, Kainate, Receptors, Kainate, Receptors, Tocris Bioscience

Citations for NS 3763

Citations are publications that use Tocris products.

Currently there are no citations for NS 3763. Do you know of a great paper that uses NS 3763 from Tocris? If so please let us know.

Reviews for NS 3763

There are currently no reviews for this product. Be the first to review NS 3763 and earn rewards!

Have you used NS 3763?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area


Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.

Learning & Memory

Learning & Memory Poster

Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.


Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.


Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.


Schizophrenia Poster

Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.