NS 3763

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Cat.No. 2187 - NS 3763 | C22H16N2O6 | CAS No. 70553-45-6
Description: Selective non-competitive kainate antagonist; selective for GLUK5
Chemical Name: 4,6-Bis(benzoylamino)-1,3-benzenedicarboxylic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective non-competitive kainate receptor antagonist; displays selectivity for GLUK5 subunit-containing receptors (IC50 values are 1.6 and > 30 μM for homomeric GLUK5 and GLUK6 receptors respectively). Has minimal activity at AMPA and NMDA receptors (IC50> 30 μM).

Technical Data

M. Wt 404.38
Formula C22H16N2O6
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 70553-45-6
PubChem ID 4359312
InChI Key UUDYZUDTQPLDDP-UHFFFAOYSA-N
Smiles O=C(C2=CC=CC=C2)NC1=CC(NC(C3=CC=CC=C3)=O)=C(C(O)=O)C=C1C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.11 25

Preparing Stock Solutions

The following data is based on the product molecular weight 404.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.47 mL 12.36 mL 24.73 mL
5 mM 0.49 mL 2.47 mL 4.95 mL
10 mM 0.25 mL 1.24 mL 2.47 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Christensen et al (2004) In vitro characterization of 5-carboxyl-2,4-di-benzamido-benzoic acid (NS3763), a noncompetitive antagonist of GLUK5 receptors. J.Pharmacol.Exp.Ther. 309 1003 PMID: 14985418


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Keywords: NS 3763, supplier, Selective, non-competitive, kainate, antagonists, selective, GLUK5, Glutamate, Kainate, Receptors, iGluR, Ionotropic, NS3763, Kainate, Receptors, Tocris Bioscience

Citations for NS 3763

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Pathways for NS 3763

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