NS 19504

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Cat.No. 5276 - NS 19504 | C10H9BrN2S | CAS No. 327062-46-4
Description: Activator of BKCa (KCa1.1) channels
Chemical Name: 5-[(4-Bromophenyl)methyl]-2-thiazolamine
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1) (EC50 = 11 μM). Activates BK channels in native smooth muscle cells from guinea pig bladder and reduces spontaneous phasic contractions in bladder strips ex vivo. Displays no effect on contractions induced by a high K+ concentration or at 65 other receptors tested, including L- and N- type Ca2+ channels, Nav, KATP and hERG channels.

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Technical Data

M. Wt 269.16
Formula C10H9BrN2S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 327062-46-4
PubChem ID 727750
InChI Key HGWLTZOMQZIUBW-UHFFFAOYSA-N
Smiles NC1=NC=C(CC2=CC=C(Br)C=C2)S1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 26.92 100
DMSO 26.92 100

Preparing Stock Solutions

The following data is based on the product molecular weight 269.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.72 mL 18.58 mL 37.15 mL
5 mM 0.74 mL 3.72 mL 7.43 mL
10 mM 0.37 mL 1.86 mL 3.72 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

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References

References are publications that support the biological activity of the product.

Nausch et al (2014) NS19504: a novel BK channel activator with relaxing effect on bladder smooth muscle spontaneous phasic contractions. J.Pharmacol.Exp.Ther. 350 520 PMID: 24951278


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