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Selective activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1) (EC50 = 11 μM). Activates BK channels in native smooth muscle cells from guinea pig bladder and reduces spontaneous phasic contractions in bladder strips ex vivo. Displays no effect on contractions induced by a high K+ concentration or at 65 other receptors tested, including L- and N- type Ca2+ channels, Nav, KATP and hERG channels.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 269.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.72 mL||18.58 mL||37.15 mL|
|5 mM||0.74 mL||3.72 mL||7.43 mL|
|10 mM||0.37 mL||1.86 mL||3.72 mL|
|50 mM||0.07 mL||0.37 mL||0.74 mL|
References are publications that support the biological activity of the product.
Nausch et al (2014) NS19504: a novel BK channel activator with relaxing effect on bladder smooth muscle spontaneous phasic contractions. J.Pharmacol.Exp.Ther. 350 520 PMID: 24951278
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Keywords: NS 19504, NS 19504 supplier, NS19504, activators, large, conductance, calcium, Ca2+-activated, potassium, channels, BKCa,, KCa1.1, Ca2+-Activated, Potassium, Channels, 5276, Tocris Bioscience
Citations for NS 19504
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Reviews for NS 19504
Average Rating: 4 (Based on 1 Review.)
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The product is a BK channel opener and it performs well under channel opening conditions.In labs the product was stable, and did extremely well in experimental studies.
Literature in this Area
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Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.