NS 11021

Pricing Availability   Qty
Description: KCa1.1 (BK) channel activator
Chemical Name: N'-[3,5-Bis(trifluoromethyl)phenyl]-N-[4-bromo-2-(2H-tetrazol-5-yl-phenyl]thiourea
Purity: ≥98% (HPLC)
Citations (2)
Reviews (2)

Biological Activity for NS 11021

NS 11021 is an activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1). Exhibits no modulatory effect on a variety of K+ (KV), Na+ and Ca2+ currents at concentrations <10 μM. Alters gating kinetics, but does not affect single channel conductance. Shown to bind BKCa in open and closed conformations; thought to bind the α subunit.

Compound Libraries for NS 11021

NS 11021 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for NS 11021

M. Wt 511.24
Formula C16H9BrF6N6S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 956014-19-0
PubChem ID 24825677
Smiles BrC1=CC(C2=NN=NN2)=C(NC(NC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)=S)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NS 11021

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 51.12 100
DMSO 51.12 100

Preparing Stock Solutions for NS 11021

The following data is based on the product molecular weight 511.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.96 mL 9.78 mL 19.56 mL
5 mM 0.39 mL 1.96 mL 3.91 mL
10 mM 0.2 mL 0.98 mL 1.96 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

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References for NS 11021

References are publications that support the biological activity of the product.

Layne et al (2009) BK channel activation by NS11021 decreases excitability and contractility of urinary bladder smooth muscle. Am.J.Physiol.Regul.Integr.Comp.Physiol. 298 R378 PMID: 19923353

Bentzen et al (2007) The small molecule NS11021 is a potent and specific activator of Ca2+-activated big-conductance K+ channels. Mol.Pharmacol. 72 1033 PMID: 17636045

Kun et al (2009) NS11021, a novel opener of large-conductance Ca2+-activated K+ channels, enhances erectile responses in rats. Br.J.Pharmacol. 158 1465 PMID: 19845682

If you know of a relevant reference for NS 11021, please let us know.

View Related Products by Product Action

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Keywords: NS 11021, NS 11021 supplier, NS11021, NS_11021, BKCa, KCa1.1, large-conductance, Ca2+-activated, Ca2+-dependent, calcium, potassium, K+, channels, activators, activates, openers, opens, Ca2+-Activated, Potassium, Channels, 4788, Tocris Bioscience

2 Citations for NS 11021

Citations are publications that use Tocris products. Selected citations for NS 11021 include:

Peter C et al (2022) FMRP Sustains Presynaptic Function via Control of Activity-Dependent Bulk Endocytosis. J Neurosci 42 1618-1628 PMID: 34996816

Bellono (2017) Molecular basis of ancestral vertebrate electroreception. Nature 543 391 PMID: 28264196

Do you know of a great paper that uses NS 11021 from Tocris? Please let us know.

Reviews for NS 11021

Average Rating: 5 (Based on 2 Reviews.)

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The pharmacological inhibitors for electrophysiology assay.
By Anonymous on 02/28/2020
Assay Type: In Vitro
Species: Other

The following concentrations we were used:1 μM Bay K, 10 μM nifedipine, 10 μM nimodipine, 300 nM omega -agatoxin, 1 μM omega -conotoxin, 5 μM mibefradil, 1 μM tetrodotoxin, 1 μM charybdotoxin, 100 nM iberiotoxin, 10 μM NS11021.

PMID: 28264196
review image

Great standard calcium activated potassium channel activator for K+ activation experiments.
By Farzana Islam on 10/06/2018
Assay Type: In Vitro
Species: Human

NS 11021 was used as a standard BK channel opener as it is an activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1). It performed well under lab conditions. Needs to be dissolved in organic solvent, ethanol and DMSO are good options for that.

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