NS 11021

Pricing Availability Delivery Time Qty
Cat.No. 4788 - NS 11021 | C16H9BrF6N6S | CAS No. 956014-19-0
Description: Activator of BKCa (KCa1.1) channels
Chemical Name: N'-[3,5-Bis(trifluoromethyl)phenyl]-N-[4-bromo-2-(2H-tetrazol-5-yl-phenyl]thiourea
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1). Exhibits no modulatory effect on a variety of K+ (KV), Na+ and Ca2+ currents at concentrations <10 μM. Alters gating kinetics, but does not affect single channel conductance. Shown to bind BKCa in open and closed conformations; thought to bind the α subunit.

Compound Libraries

NS 11021 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 511.24
Formula C16H9BrF6N6S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 956014-19-0
PubChem ID 24825677
InChI Key MDKAFDIKYQMOMF-UHFFFAOYSA-N
Smiles BrC1=CC(C2=NN=NN2)=C(NC(NC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)=S)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 51.12 100
ethanol 51.12 100

Preparing Stock Solutions

The following data is based on the product molecular weight 511.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.96 mL 9.78 mL 19.56 mL
5 mM 0.39 mL 1.96 mL 3.91 mL
10 mM 0.2 mL 0.98 mL 1.96 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Layne et al (2009) BK channel activation by NS11021 decreases excitability and contractility of urinary bladder smooth muscle. Am.J.Physiol.Regul.Integr.Comp.Physiol. 298 R378 PMID: 19923353

Bentzen et al (2007) The small molecule NS11021 is a potent and specific activator of Ca2+-activated big-conductance K+ channels. Mol.Pharmacol. 72 1033 PMID: 17636045

Kun et al (2009) NS11021, a novel opener of large-conductance Ca2+-activated K+ channels, enhances erectile responses in rats. Br.J.Pharmacol. 158 1465 PMID: 19845682


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View Related Products by Product Action

View all Calcium-Activated Potassium (KCa) Channel Activators

Keywords: NS11021 NS_11021 BKCa KCa1.1 large-conductance Ca2+-activated Ca2+-dependent calcium potassium K+ channels activators activates openers opens Ca2+-Activated Potassium Channels

1 Citation for NS 11021

Citations are publications that use Tocris products. Selected citations for NS 11021 include:

Bellono (2017) Molecular basis of ancestral vertebrate electroreception. Nature 543 391 PMID: 28264196


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