NS 11021

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Cat.No. 4788 - NS 11021 | C16H9BrF6N6S | CAS No. 956014-19-0
Description: Activator of BKCa (KCa1.1) channels
Chemical Name: N'-[3,5-Bis(trifluoromethyl)phenyl]-N-[4-bromo-2-(2H-tetrazol-5-yl-phenyl]thiourea
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews (1)
Literature

Biological Activity

Activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1). Exhibits no modulatory effect on a variety of K+ (KV), Na+ and Ca2+ currents at concentrations <10 μM. Alters gating kinetics, but does not affect single channel conductance. Shown to bind BKCa in open and closed conformations; thought to bind the α subunit.

Compound Libraries

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Technical Data

M. Wt 511.24
Formula C16H9BrF6N6S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 956014-19-0
PubChem ID 24825677
InChI Key MDKAFDIKYQMOMF-UHFFFAOYSA-N
Smiles BrC1=CC(C2=NN=NN2)=C(NC(NC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)=S)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 51.12 100
ethanol 51.12 100

Preparing Stock Solutions

The following data is based on the product molecular weight 511.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.96 mL 9.78 mL 19.56 mL
5 mM 0.39 mL 1.96 mL 3.91 mL
10 mM 0.2 mL 0.98 mL 1.96 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

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References

References are publications that support the biological activity of the product.

Layne et al (2009) BK channel activation by NS11021 decreases excitability and contractility of urinary bladder smooth muscle. Am.J.Physiol.Regul.Integr.Comp.Physiol. 298 R378 PMID: 19923353

Bentzen et al (2007) The small molecule NS11021 is a potent and specific activator of Ca2+-activated big-conductance K+ channels. Mol.Pharmacol. 72 1033 PMID: 17636045

Kun et al (2009) NS11021, a novel opener of large-conductance Ca2+-activated K+ channels, enhances erectile responses in rats. Br.J.Pharmacol. 158 1465 PMID: 19845682


If you know of a relevant reference for NS 11021, please let us know.

View Related Products by Product Action

View all Calcium-Activated Potassium (KCa) Channel Activators

Keywords: NS 11021, NS 11021 supplier, NS11021, NS_11021, BKCa, KCa1.1, large-conductance, Ca2+-activated, Ca2+-dependent, calcium, potassium, K+, channels, activators, activates, openers, opens, Ca2+-Activated, Potassium, Channels, 4788, Tocris Bioscience

1 Citation for NS 11021

Citations are publications that use Tocris products. Selected citations for NS 11021 include:

Bellono (2017) Molecular basis of ancestral vertebrate electroreception. Nature 543 391 PMID: 28264196


Do you know of a great paper that uses NS 11021 from Tocris? Please let us know.

Reviews for NS 11021

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Great standard calcium activated potassium channel activator for K+ activation experiments
By Farzana Islam on 10/06/2018
Assay Type: In Vitro
Species: Human

NS 11021 was used as a standard BK channel opener as it is an activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1). It performed well under lab conditions. Needs to be dissolved in organic solvent, ethanol and DMSO are good options for that.

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