NPS ALX Compound 4a dihydrochloride

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Cat.No. 3285 - NPS ALX Compound 4a dihydrochloride | C25H25N3O2S.2HCl | CAS No. 299433-10-6
Description: Potent and selective 5-HT6 antagonist
Chemical Name: 6-(Hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-1-(1-naphthalenylsulfonyl)-1H-indole dihydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and competitive 5-HT6 antagonist (IC50 = 7.2 nM, Ki = 0.2 nM) that displays selectivity over other 5-HT and D2 receptors.

Technical Data

M. Wt 504.47
Formula C25H25N3O2S.2HCl
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 299433-10-6
PubChem ID 56972226
InChI Key XQQYORJJFZQWNA-UHFFFAOYSA-N
Smiles O=S(N2C1=CC(N5CCN(CCC6)C6C5)=CC=C1C=C2)(C3=C(C=CC=C4)C4=CC=C3)=O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 50.45 100

Preparing Stock Solutions

The following data is based on the product molecular weight 504.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.98 mL 9.91 mL 19.82 mL
5 mM 0.4 mL 1.98 mL 3.96 mL
10 mM 0.2 mL 0.99 mL 1.98 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Isaac et al (2000) 6-bicyclopiperazinyl-1-arylsulfonylindoles and 6-bicyclopiperidinyl-1-arylsulfonylindoles derivatives as novel, potent, and selective 5-HT6 receptor antagonists. Bioorg.Med.Chem.Letts. 10 1719 PMID:


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Citations for NPS ALX Compound 4a dihydrochloride

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