NPS ALX Compound 4a dihydrochloride

Discontinued Product

NPS ALX Compound 4a dihydrochloride (Cat. No. 3285) has been withdrawn from sale for commercial reasons.
Cat.No. 3285 - NPS ALX Compound 4a dihydrochloride | C25H25N3O2S.2HCl | CAS No. 1781934-44-8
Description: Potent and selective 5-HT6 antagonist
Chemical Name: 6-(Hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-1-(1-naphthalenylsulfonyl)-1H-indole dihydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (4)

Biological Activity for NPS ALX Compound 4a dihydrochloride

NPS ALX Compound 4a dihydrochloride is a potent and competitive 5-HT6 antagonist (IC50 = 7.2 nM, Ki = 0.2 nM) that displays selectivity over other 5-HT and D2 receptors.

Technical Data for NPS ALX Compound 4a dihydrochloride

M. Wt 504.47
Formula C25H25N3O2S.2HCl
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1781934-44-8
PubChem ID 56972226
InChI Key XQQYORJJFZQWNA-UHFFFAOYSA-N
Smiles O=S(N2C1=CC(N5CCN(CCC6)C6C5)=CC=C1C=C2)(C3=C(C=CC=C4)C4=CC=C3)=O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for NPS ALX Compound 4a dihydrochloride

References for NPS ALX Compound 4a dihydrochloride

References are publications that support the biological activity of the product.

Isaac et al (2000) 6-bicyclopiperazinyl-1-arylsulfonylindoles and 6-bicyclopiperidinyl-1-arylsulfonylindoles derivatives as novel, potent, and selective 5-HT6 receptor antagonists. Bioorg.Med.Chem.Letts. 10 1719

View Related Products by Target

View Related Products by Product Action

View all 5-HT6 Receptor Antagonists

Keywords: NPS ALX Compound 4a dihydrochloride, NPS ALX Compound 4a dihydrochloride supplier, Potent, selective, 5-HT6, antagonists, Serotonin, Receptors, 5-Hydroxytryptamine, NPSALX, Compound4a, dihydrochloride, 3285, Tocris Bioscience

Citations for NPS ALX Compound 4a dihydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for NPS ALX Compound 4a dihydrochloride.

Reviews for NPS ALX Compound 4a dihydrochloride

There are currently no reviews for this product. Be the first to review NPS ALX Compound 4a dihydrochloride and earn rewards!

Have you used NPS ALX Compound 4a dihydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Alzheimer's

Alzheimer's Poster

Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.