NPS ALX Compound 4a dihydrochloride

Discontinued Product

NPS ALX Compound 4a dihydrochloride (Cat. No. 3285) has been withdrawn from sale for commercial reasons.
Description: Potent and selective 5-HT6 antagonist
Chemical Name: 6-(Hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-1-(1-naphthalenylsulfonyl)-1H-indole dihydrochloride
Purity: ≥99% (HPLC)
Literature (2)

Biological Activity for NPS ALX Compound 4a dihydrochloride

NPS ALX Compound 4a dihydrochloride is a potent and competitive 5-HT6 antagonist (IC50 = 7.2 nM, Ki = 0.2 nM) that displays selectivity over other 5-HT and D2 receptors.

Technical Data for NPS ALX Compound 4a dihydrochloride

M. Wt 504.47
Formula C25H25N3O2S.2HCl
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1781934-44-8
PubChem ID 56972226
Smiles O=S(N2C1=CC(N5CCN(CCC6)C6C5)=CC=C1C=C2)(C3=C(C=CC=C4)C4=CC=C3)=O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for NPS ALX Compound 4a dihydrochloride

References for NPS ALX Compound 4a dihydrochloride

References are publications that support the biological activity of the product.

Isaac et al (2000) 6-bicyclopiperazinyl-1-arylsulfonylindoles and 6-bicyclopiperidinyl-1-arylsulfonylindoles derivatives as novel, potent, and selective 5-HT6 receptor antagonists. Bioorg.Med.Chem.Letts. 10 1719

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Citations for NPS ALX Compound 4a dihydrochloride

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Currently there are no citations for NPS ALX Compound 4a dihydrochloride.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Alzheimer's Disease Poster

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.