NPEC-caged-serotonin

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Cat.No. 3991 - NPEC-caged-serotonin | C19H19N3O5 | CAS No. 1257326-22-9
Description: Caged serotonin
Chemical Name: 3-((N)-1-(2-Nitrophenyl)ethylcarboxy)-(2-Aminoethyl)-1H-indol-5-ol
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

NPEC ((N)-1-(2-nitrophenyl)ethyl) caged version of serotonin (Cat. No. 3547).

Technical Data

M. Wt 369.37
Formula C19H19N3O5
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 1257326-22-9
PubChem ID 90488900
InChI Key KUEQXJVRVDFKJY-UHFFFAOYSA-N
Smiles CC(OC(NCCC2=CNC3=C2C=C(O)C=C3)=O)C1=C([N+]([O-])=O)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.94 100
ethanol 36.94 100

Preparing Stock Solutions

The following data is based on the product molecular weight 369.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.71 mL 13.54 mL 27.07 mL
5 mM 0.54 mL 2.71 mL 5.41 mL
10 mM 0.27 mL 1.35 mL 2.71 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

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Keywords: caged serotonin compounds neurotransmitters 5-HT receptors serotonergic Non-selective 5-HT

1 Citation for NPEC-caged-serotonin

Citations are publications that use Tocris products. Selected citations for NPEC-caged-serotonin include:

Gantz et al (2015) Depression of Serotonin Synaptic Transmission by the Dopamine Precursor L-DOPA. Cell Rep. 12 944 PMID: 26235617


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Literature in this Area

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
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  • GPCR Signaling
5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Depression

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Pathways for NPEC-caged-serotonin

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