Discontinued Product

NoxA1ds (Cat. No. 5848) has been withdrawn from sale for commercial reasons.
Description: Potent and selective NADPH oxidase 1 (NOX1) inhibitor
Literature (1)

Biological Activity for NoxA1ds

NoxA1ds is a potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 = 20 nM). Exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. Inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. Attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro. Cell permeable.

Technical Data for NoxA1ds

M. Wt 1125.33
Formula C50H88N14O15

(Modifications: Val-11 = C-terminal amide)

Storage Store at -20°C
CAS Number 1435893-78-9
PubChem ID 121513898
Smiles [H]N[C@@H](CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for NoxA1ds

Certificate of Analysis / Product Datasheet
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References for NoxA1ds

References are publications that support the biological activity of the product.

Ranayhossaini et al (2013) Selective recapitulation of conserved and nonconserved regions of putative NOXA1 protein activation domain confers isoform-specific inhibition of Nox1 oxidase and attenuation of endothelial cell migration. J.Biol.Chem. 288 36437 PMID: 24187133

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Keywords: NoxA1ds, NoxA1ds supplier, NADPH, oxidases, NOX1, inhibitors, inhibits, hypoxia, ROS, reactive, oxygen, species, Oxidase, 5848, Tocris Bioscience

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Literature in this Area

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