NoxA1ds

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Cat.No. 5848 - NoxA1ds | Glu-Pro-Val-Asp-Ala-Leu-Gly-Lys-Ala-Lys-Val-NH2 | CAS No. 1435893-78-9
Description: Potent and selective NADPH oxidase 1 (NOX1) inhibitor
Datasheet
Citations
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Literature

Biological Activity

Potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 = 20 nM). Exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. Inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. Attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro. Cell permeable.

Technical Data

M. Wt 1125.33
Formula C50H88N14O15
Sequence EPVDALGKAKV

(Modifications: Val-11 = C-terminal amide)

Storage Store at -20°C
CAS Number 1435893-78-9
PubChem ID 121513898
InChI Key DHBOJLLJKHKZGT-XTGVMIFDSA-N
Smiles [H]N[C@@H](CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1125.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.89 mL 4.44 mL 8.89 mL
5 mM 0.18 mL 0.89 mL 1.78 mL
10 mM 0.09 mL 0.44 mL 0.89 mL
50 mM 0.02 mL 0.09 mL 0.18 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Ranayhossaini et al (2013) Selective recapitulation of conserved and nonconserved regions of putative NOXA1 protein activation domain confers isoform-specific inhibition of Nox1 oxidase and attenuation of endothelial cell migration. J.Biol.Chem. 288 36437 PMID: 24187133


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Keywords: NoxA1ds, supplier, NADPH, oxidases, NOX1, inhibitors, inhibits, hypoxia, ROS, reactive, oxygen, species, NADPH, Oxidase, NADPH, Oxidase, Tocris Bioscience

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Literature in this Area

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