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Cat.No. 3615 - Novokinin | Arg-Pro-Leu-Lys-Pro-Trp | CAS No. 358738-77-9
Description: AT2 agonist; orally active
Literature (4)

Biological Activity

Angiotensin AT2 receptor agonist (Ki = 7.35 μM) that displays 93-fold selectivity over AT1. Exhibits vasorelaxing and hypotensive activity via activation of the IP (prostacyclin) receptor, and suppresses food intake via activation of PGE2-EP4. Orally active.

Technical Data

M. Wt 795.98
Formula C39H61N11O7
Sequence RPLKPW
Storage Desiccate at -20°C
CAS Number 358738-77-9
PubChem ID 9987879
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Yamada et al (2008) A potent hypotensive peptide, novokinin, induces relaxation by AT2- and IP-receptor-dependent mechanism in the mesenteric artery from SHRs. Biosci.Biotechnol.Biochem. 72 257 PMID: 18175894

Yamada et al (2008) Hypotensive activity of novokinin, a potent analogue of ovokinin(2-7), is mediated by angiotensin AT2 receptor and prostaglandin IP receptor. Peptides 29 412 PMID: 18207609

Ohinata et al (2009) Orally administered novokinin, an angiotensin AT2 receptor agonist, suppresses food intake via prostaglandin E2-dependent mechanism in mice. Peptides 30 1105 PMID: 19463743

If you know of a relevant reference for Novokinin, please let us know.

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Keywords: Novokinin, Novokinin supplier, Orally, active, agonists, Angiotensin, Receptors, AT2, 3615, Tocris Bioscience

Citations for Novokinin

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