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Angiotensin AT2 receptor agonist (Ki = 7.35 μM) that displays 93-fold selectivity over AT1. Exhibits vasorelaxing and hypotensive activity via activation of the IP (prostacyclin) receptor, and suppresses food intake via activation of PGE2-EP4. Orally active.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 1 mg/ml in water|
References are publications that support the biological activity of the product.
Yamada et al (2008) A potent hypotensive peptide, novokinin, induces relaxation by AT2- and IP-receptor-dependent mechanism in the mesenteric artery from SHRs. Biosci.Biotechnol.Biochem. 72 257 PMID: 18175894
Yamada et al (2008) Hypotensive activity of novokinin, a potent analogue of ovokinin(2-7), is mediated by angiotensin AT2 receptor and prostaglandin IP receptor. Peptides 29 412 PMID: 18207609
Ohinata et al (2009) Orally administered novokinin, an angiotensin AT2 receptor agonist, suppresses food intake via prostaglandin E2-dependent mechanism in mice. Peptides 30 1105 PMID: 19463743
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Keywords: Novokinin, Novokinin supplier, Orally, active, agonists, Angiotensin, Receptors, AT2, 3615, Tocris Bioscience
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