Novokinin

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Cat.No. 3615 - Novokinin | Arg-Pro-Leu-Lys-Pro-Trp | CAS No. 358738-77-9
Description: Orally active AT2 agonist
Datasheet
Citations
Literature

Biological Activity

Angiotensin AT2 receptor agonist (Ki = 7.35 μM) that displays 93-fold selectivity over AT1. Exhibits vasorelaxing and hypotensive activity via activation of the IP (prostacyclin) receptor, and suppresses food intake via activation of PGE2-EP4. Orally active.

Technical Data

M. Wt 795.98
Formula C39H61N11O7
Sequence RPLKPW
Storage Desiccate at -20°C
CAS Number 358738-77-9
PubChem ID 9987879
InChI Key WCJSVACAALWGRF-LQPYQXOBSA-N
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 795.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.26 mL 6.28 mL 12.56 mL
5 mM 0.25 mL 1.26 mL 2.51 mL
10 mM 0.13 mL 0.63 mL 1.26 mL
50 mM 0.03 mL 0.13 mL 0.25 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Yamada et al (2008) A potent hypotensive peptide, novokinin, induces relaxation by AT2- and IP-receptor-dependent mechanism in the mesenteric artery from SHRs. Biosci.Biotechnol.Biochem. 72 257 PMID: 18175894

Yamada et al (2008) Hypotensive activity of novokinin, a potent analogue of ovokinin(2-7), is mediated by angiotensin AT2 receptor and prostaglandin IP receptor. Peptides 29 412 PMID: 18207609

Ohinata et al (2009) Orally administered novokinin, an angiotensin AT2 receptor agonist, suppresses food intake via prostaglandin E2-dependent mechanism in mice. Peptides 30 1105 PMID: 19463743


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Keywords: Orally active agonists Angiotensin Receptors AT2 Angiotensin AT2 Receptors

Citations for Novokinin

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Literature in this Area

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Pathways for Novokinin

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