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Description: Nicotinamide N-methyltransferase (NNMT) inhibitor; promotes myoblast differentiation
Chemical Name: 5-Amino-1-methylquinolinium iodide
Purity: ≥97% (HPLC)

Biological Activity for NNMTi

NNMTi is a nicotinamide N-methyltransferase (NNMT) inhibitor (IC50 = 1.2 μM). Promotes myoblast differentiation in C2C12 cells. Activates senescent muscle stem cells (muSCs) and improves regenerative capacity of aged skeletal muscle. Enhances proliferation, fusion and regenerative capacity of muSCs in aged mice.

Technical Data for NNMTi

M. Wt 286.11
Formula C10H11IN2
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 42464-96-0
PubChem ID 66522933
Smiles [I-].C[N+]1=CC=CC2=C(N)C=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NNMTi

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 28.61 100

Preparing Stock Solutions for NNMTi

The following data is based on the product molecular weight 286.11. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.5 mL 17.48 mL 34.95 mL
5 mM 0.7 mL 3.5 mL 6.99 mL
10 mM 0.35 mL 1.75 mL 3.5 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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References for NNMTi

References are publications that support the biological activity of the product.

Neelakantan et al (2019) Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. Biochem. Pharmacol. 163 481 PMID: 30753815

Neelakantan et al (2017) Structure-activity relationship for small molecule inhibitors of nicotinamide N-methyltransferase. J.Med.Chem. 60 5015 PMID: 28548833

If you know of a relevant reference for NNMTi, please let us know.

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Keywords: NNMTi, NNMTi supplier, Nicotinamide, N, Methyltransferase, NNMT, inhibitors, inhibits, myoblast, differentiation, muscle, stem, cells, aged, Other, Transferases, Differentiation, Products, 6900, Tocris Bioscience

Citations for NNMTi

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