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Biological Activity for NNMTi
NNMTi is a nicotinamide N-methyltransferase (NNMT) inhibitor (IC50 = 1.2 μM). Promotes myoblast differentiation in C2C12 cells. Activates senescent muscle stem cells (muSCs) and improves regenerative capacity of aged skeletal muscle. Enhances proliferation, fusion and regenerative capacity of muSCs in aged mice.
Technical Data for NNMTi
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NNMTi
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for NNMTi
The following data is based on the product molecular weight 286.11. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.5 mL||17.48 mL||34.95 mL|
|5 mM||0.7 mL||3.5 mL||6.99 mL|
|10 mM||0.35 mL||1.75 mL||3.5 mL|
|50 mM||0.07 mL||0.35 mL||0.7 mL|
References for NNMTi
References are publications that support the biological activity of the product.
Neelakantan et al (2019) Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. Biochem. Pharmacol. 163 481 PMID: 30753815
Neelakantan et al (2017) Structure-activity relationship for small molecule inhibitors of nicotinamide N-methyltransferase. J.Med.Chem. 60 5015 PMID: 28548833
If you know of a relevant reference for NNMTi, please let us know.
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Keywords: NNMTi, NNMTi supplier, Nicotinamide, N, Methyltransferase, NNMT, inhibitors, inhibits, myoblast, differentiation, muscle, stem, cells, aged, Other, Transferases, Differentiation, Products, 6900, Tocris Bioscience
Citations for NNMTi
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