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Biological Activity for NNC 26-9100
NNC 26-9100 is a somatostatin sst4 receptor agonist that displays > 100-fold selectivity over sst2 receptors (Ki values are 6 and 621 nM for sst4 and sst2 receptors respectively). Potently inhibits forskolin-induced cAMP accumulation (EC50 = 26 nM).
Compound Libraries for NNC 26-9100
Technical Data for NNC 26-9100
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NNC 26-9100
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for NNC 26-9100
The following data is based on the product molecular weight 556.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||3.59 mL||17.97 mL||35.95 mL|
|2.5 mM||0.72 mL||3.59 mL||7.19 mL|
|5 mM||0.36 mL||1.8 mL||3.59 mL|
|25 mM||0.07 mL||0.36 mL||0.72 mL|
References for NNC 26-9100
References are publications that support the biological activity of the product.
Liu et al (1998) Nonpeptide somatostatin agonists with sst4 selectivity: synthesis and structure-activity relationships of thioureas. J.Med.Chem. 41 4693 PMID: 9822540
Liu et al (1999) 2-pyridylthioureas: novel nonpeptide somatostatin agonists with SST4 selectivity. Curr.Pharm.Des. 5 255 PMID: 10101224
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Keywords: NNC 26-9100, NNC 26-9100 supplier, Selective, sst4, agonists, Receptors, Somatostatin, NNC269100, 2440, Tocris Bioscience
1 Citation for NNC 26-9100
Citations are publications that use Tocris products. Selected citations for NNC 26-9100 include:
Honda et al (2012) Inhibitory effect of somatostatin receptor subtype-4 agonist NNC 26-9100 on micturition reflex in rats. Urology 80 1391000000000 PMID: 22951005
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