NNC 26-9100

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Cat.No. 2440 - NNC 26-9100 | C22H25N6Cl2SBr | CAS No. 199522-35-5
Description: Selective sst4 agonist
Chemical Name: 1-[3-[N-(5-Bromopyridin-2-yl)-N-(3,4-dichlorobenzyl)amino]propyl]-3-[3-(1H-imidazol-4-yl)propyl]thiourea
Purity: ≥99% (HPLC)
Citations (1)
Literature (3)

Biological Activity

Somatostatin sst4 receptor agonist that displays > 100-fold selectivity over sst2 receptors (Ki values are 6 and 621 nM for sst4 and sst2 receptors respectively). Potently inhibits forskolin-induced cAMP accumulation (EC50 = 26 nM).

Compound Libraries

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Technical Data

M. Wt 556.35
Formula C22H25N6Cl2SBr
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 199522-35-5
PubChem ID 9893924
Smiles ClC1=C(Cl)C=C(CN(CCCNC(=S)NCCCC2=CNC=N2)C2=CC=C(Br)C=N2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 27.82 50
ethanol 27.82 50

Preparing Stock Solutions

The following data is based on the product molecular weight 556.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.59 mL 17.97 mL 35.95 mL
2.5 mM 0.72 mL 3.59 mL 7.19 mL
5 mM 0.36 mL 1.8 mL 3.59 mL
25 mM 0.07 mL 0.36 mL 0.72 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Liu et al (1998) Nonpeptide somatostatin agonists with sst4 selectivity: synthesis and structure-activity relationships of thioureas. J.Med.Chem. 41 4693 PMID: 9822540

Liu et al (1999) 2-pyridylthioureas: novel nonpeptide somatostatin agonists with SST4 selectivity. Curr.Pharm.Des. 5 255 PMID: 10101224

If you know of a relevant reference for NNC 26-9100, please let us know.

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Keywords: NNC 26-9100, NNC 26-9100 supplier, Selective, sst4, agonists, Receptors, Somatostatin, NNC269100, 2440, Tocris Bioscience

1 Citation for NNC 26-9100

Citations are publications that use Tocris products. Selected citations for NNC 26-9100 include:

Honda et al (2012) Inhibitory effect of somatostatin receptor subtype-4 agonist NNC 26-9100 on micturition reflex in rats. Urology 80 1391000000000 PMID: 22951005

Do you know of a great paper that uses NNC 26-9100 from Tocris? Please let us know.

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Literature in this Area

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