Nimesulide

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Cat.No. 2470 - Nimesulide | C13H12N2O5S | CAS No. 51803-78-2
Description: Cyclooxygenase-2 (COX-2) inhibitor
Alternative Names: Flogovital, Aulin
Chemical Name: N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews
Literature

Biological Activity

Selective, orally active cyclooxygenase-2 (COX-2) inhibitor. Produces potent analgesic, anti-inflammatory and antipyretic activities in vivo. Reported to produce fewer gastrointestinal side effects than standard NSAIDs. .

Technical Data

M. Wt 308.31
Formula C13H12N2O5S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 51803-78-2
PubChem ID 4495
InChI Key HYWYRSMBCFDLJT-UHFFFAOYSA-N
Smiles CS(=O)(=O)NC1=C(OC2=CC=CC=C2)C=C(C=C1)[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.83 100
ethanol 7.71 25

Preparing Stock Solutions

The following data is based on the product molecular weight 308.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.24 mL 16.22 mL 32.43 mL
5 mM 0.65 mL 3.24 mL 6.49 mL
10 mM 0.32 mL 1.62 mL 3.24 mL
50 mM 0.06 mL 0.32 mL 0.65 mL

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References

References are publications that support the biological activity of the product.

Famaey (1997) In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2 inhibition by nimesulide: an overview. Inflamm.Res. 46 437 PMID: 9427063

Cullen et al (1998) Selective cyclooxygenase-2 inhibition by nimesulide in man. J.Pharmacol.Exp.Ther. 287 578 PMID: 9808683


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Keywords: Nimesulide, Nimesulide supplier, Cyclooxygenase-2, COX-2, inhibitors, inhibits, Cyclooxygenase, Oxygenases, Oxidases, Flogovital, Aulin, 2470, Tocris Bioscience

3 Citations for Nimesulide

Citations are publications that use Tocris products. Selected citations for Nimesulide include:

Baranowska-Kuczko et al (2014) Mechanisms of endothelium-dependent relaxation evoked by anandamide in isolated human pulmonary arteries. J Neuroimmune Pharmacol 387 477 PMID: 24682422

Anneken et al (2013) MDMA increases glutamate release and reduces parvalbumin-positive GABAergic cells in the dorsal hippocampus of the rat: role of cyclooxygenase. Nat Commun 8 58 PMID: 23179355

Staniaszek et al (2010) Effects of COX-2 inhibition on spinal nociception: the role of endocannabinoids. Br J Pharmacol 160 669 PMID: 20590570


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