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Submit ReviewNimesulide
Description: Cyclooxygenase-2 (COX-2) inhibitor
Alternative Names: Flogovital,Aulin
Chemical Name: N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide
Purity: ≥99% (HPLC)
Biological Activity for Nimesulide
Nimesulide is a selective, orally active cyclooxygenase-2 (COX-2) inhibitor. Produces potent analgesic, anti-inflammatory and antipyretic activities in vivo. Reported to produce fewer gastrointestinal side effects than standard NSAIDs. Also inhibits sodium-dependent neutral amino acid transporter B0AT1 (SLC6A19; IC50 = 23 μM).
Technical Data for Nimesulide
| M. Wt | 308.31 |
| Formula | C13H12N2O5S |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 51803-78-2 |
| PubChem ID | 4495 |
| InChI Key | HYWYRSMBCFDLJT-UHFFFAOYSA-N |
| Smiles | CS(=O)(=O)NC1=C(OC2=CC=CC=C2)C=C(C=C1)[N+]([O-])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Nimesulide
References for Nimesulide
References are publications that support the biological activity of the product.
Famaey (1997) In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2 inhibition by nimesulide: an overview. Inflamm.Res. 46 437 PMID: 9427063
Cullen et al (1998) Selective cyclooxygenase-2 inhibition by nimesulide in man. J.Pharmacol.Exp.Ther. 287 578 PMID: 9808683
Pochini et al (2014) Nimesulide binding site in the B0AT1 (SLC6A19) amino acid transporter. Mechanism of inhibition revealed by proteoliposome transport assay and molecular modelling. Biochem.Pharmacol. 89 422 PMID: 24704252
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Keywords: Nimesulide, Nimesulide supplier, Cyclooxygenase-2, COX-2, inhibitors, inhibits, Cyclooxygenase, Oxygenases, Oxidases, B0AT1, SLC6A19, sodium-dependent, neutral, amino, acid, transporter, Flogovital, Aulin, Other, Ion, Pumps/Transporters, 2470, Tocris Bioscience
3 Citations for Nimesulide
Citations are publications that use Tocris products. Selected citations for Nimesulide include:
Anneken et al (2013) MDMA increases glutamate release and reduces parvalbumin-positive GABAergic cells in the dorsal hippocampus of the rat: role of cyclooxygenase. Nat Commun 8 58 PMID: 23179355
Baranowska-Kuczko et al (2014) Mechanisms of endothelium-dependent relaxation evoked by anandamide in isolated human pulmonary arteries. J Neuroimmune Pharmacol 387 477 PMID: 24682422
Staniaszek et al (2010) Effects of COX-2 inhibition on spinal nociception: the role of endocannabinoids. Br J Pharmacol 160 669 PMID: 20590570
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